Single Source: HeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Data Translation Center (U54 Clinical Trial Optional)
Closed Posted
- Opportunity number
- RFA-HL-27-009
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Non-501(c)(3) Nonprofits
- City/Township Governments
- Other
- Tribal Governments (Federally Recognized)
- Higher Education Inst. (Private)
- State Governments
- Independent School Districts
- Special District Governments
- 501(c)(3) Nonprofits
- For Profit Organizations
- Tribal Organizations (Not Federally Recognized)
- Small Businesses
- County Governments
- Higher Education Inst. (Public)
- Public or Indian Housing Auth.
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Heart, Lung, and Blood Institute is soliciting a single-source cooperative agreement to renew the Data Translation Center for the HeartShare 2.0 program, with an application due July 9, 2026. This is a restricted-eligibility award: only individuals previously associated with the original RFA-HL-21-016 award to Northwestern University are eligible to apply, and the NHLBI intends to issue the cooperative agreement exclusively to Northwestern University.
The Data Translation Center will coordinate the overall HeartShare phenomics program, oversee enrollment and deep phenotyping of patients with heart failure with preserved ejection fraction (HFpEF), curate and analyze prospective longitudinal data including multi-omics analysis, and support planning, implementation, and data analysis for precision clinical trials. The DTC comprises three required cores: an Administrative Core ($500,000 annually for Years 1–2; $400,000 for Years 3–6), a Data Portal Core ($100,000 annually), and a Data Management Core ($400,000 annually).
The NHLBI intends to commit up to $2,541,000 in total costs for one award over a maximum six-year project period. Application budgets may request up to $1,650,000 in direct costs for FY2027, declining to $1,400,000 for FY2028 and $1,150,000 annually for FY2029–FY2032. The application submission window opens June 9, 2026. Peer review is anticipated for November 2026, advisory council review for January 2027, with an earliest start date of April 2027. A companion NOFO (RFA-HL-27-008) will support Clinical Trial Centers and Clinical Centers for recruitment and follow-up of heart failure patients. The activity code is U54 (Specialized Center–Cooperative Agreements), and clinical trials are optional. This opportunity is funded under CFDA 93.837, Cardiovascular Diseases Research.
Synopsis
This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invites an application from an eligible organization to apply. Please see Section III. Eligibility for additional information. The NHLBI is announcing its intent to issue a single source cooperative agreement to Northwestern University. This NOFO solicits a renewal of the Data Translation Center for an ongoing NHLBI phenomics program, HeartShare, to coordinate the overall project, continue to oversee enrollment of a cohort of patients with heart failure with preserved ejection fraction (HFpEF), curate and analyze prospective deep phenotyping data, and support planning, implementation, and data analysis for clinical trials. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered.Companion NOFO RFA-HL-27-008 will support Clinical Centers for recruitment and follow-up of heart failure patients and a Clinical Trial Center for new clinical trial activities.
Files
| File | Type | Posted |
|---|---|---|
| RFA-HL-27-009-Revised-Full-Announcement.html | HTML file | |
| RFA-HL-27-009-Revised-Full-Announcement.html | HTML file |
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