Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)
Open Posted
- Opportunity number
- RFA-DK-27-112
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Other
- Points of contact
-
- Albert Hwa niddk_dem@nih.gov
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is soliciting a single-source cooperative agreement application to continue the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center, with an application due by November 9, 2026. Only the current recipient under RFA-DK-21-503 is eligible to apply. NIDDK intends to commit up to $6.5 million in Fiscal Year 2027, with an application budget limit of $6.3 million per year in direct costs and a maximum project period of five years.
The research will support long-term follow-up of approximately 1,000 active EDIC participants (average age 65 years with over 40 years of type 1 diabetes history) to study development and progression of diabetes complications, including severe microvascular disease, cardiovascular and liver disease, sleep disorders, and mortality. Applications must address hypothesis-based research, cohort infrastructure maintenance and support, participant retention strategies, and collaborative research utilizing EDIC cohort data and biospecimens. The initiative emphasizes investigation of age-related morbidities including cognition, physical function, and frailty; evaluation of emerging therapies (SGLT2 inhibitors, GLP-1 receptor agonists) on renal and cardiovascular outcomes; obesity-related outcomes and comorbidities including metabolic-associated steatotic liver disease and obstructive sleep apnea; multi-omic approaches to identify biochemical signatures; and advanced statistical methods including machine learning and artificial intelligence. Clinical trials are not allowed. NIH will apply standard peer review criteria assessing significance, innovation, rigor, feasibility, and investigator expertise and resources. The award is assigned to CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Synopsis
This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite an application from the eligible organization to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, applications will be peer-reviewed, and only meritorious applications will be considered for funding. Through this NOFO, the National institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites an application to continue to follow the Epidemiology of Diabetes Interventions and Complications (EDIC) cohort through a collaborative cooperative agreement that addresses specific knowledge gaps in the development and progression of type 1 diabetes complications. Applications should include hypothesis-based research, support for cohort infrastructure and/or maintenance, continued follow-up, and supporting collaborative research to utilize the EDIC cohort as well as its data set and biologic/genetic samples.
Eligibility
This is a Forecast for a single source competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Files
| File | Type | Posted |
|---|---|---|
| PKG00294084.pdf | ||
| RFA-DK-27-112-Full-Announcement.html | HTML file |
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