Single Source: Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium- Renal and Environmental Science Core (U01-Clinical Trial Not Allowed)
Past Federal grant forecast Posted
- Opportunity number
- RFA-DK-27-137
- Agency
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National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
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- Health
- Eligible applicants
-
- Small Businesses
- Public or Indian Housing Auth.
- Tribal Governments (Federally Recognized)
- Higher Education Inst. (Private)
- County Governments
- Non-501(c)(3) Nonprofits
- State Governments
- Tribal Organizations (Not Federally Recognized)
- For Profit Organizations
- Special District Governments
- 501(c)(3) Nonprofits
- Higher Education Inst. (Public)
- Points of contact
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- Tracy Rankin niddk_kuh@nih.gov (301) 594-6417
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health seeks applicants for the Renal and Environmental Science Core of the Chronic Kidney Disease of Uncertain Etiology in Agricultural Communities (CURE) Research Consortium, a cooperative agreement to advance discovery science on CKDu risk factors and disease progression, via a single-source funding opportunity (forecast posted February 5, 2026).
Eligible applicants include higher education institutions (public and private), 501(c)(3) nonprofits, non-501(c)(3) nonprofits, state and county governments, tribal governments (federally and non-federally recognized), tribal organizations, small businesses, for-profit organizations, special district governments, Indian housing authorities, federal agencies, U.S. territories or possessions, faith-based or community-based organizations, regional organizations, and non-domestic entities.
The consortium, jointly funded by NIDDK, NIEHS, and FIC since 2021, includes Field Epidemiology Sites, this Renal and Environmental Science Core, and a Data Coordinating Center. The Core will provide support and leadership in discovery science to understand etiologies of CKDu, exposures that initiate and affect tubulointerstitial kidney disease progression, potential therapeutic targets, and opportunities for public health interventions. Consortium members will continue collaboration to maximize scientific opportunities and serve as a resource for ancillary studies. The research addresses environmental factors suspected as causative in rural areas of Low and Middle Income Countries while offering insights into kidney disease mechanisms relevant to U.S. populations.
Applications undergo peer review and are funded only if meritorious. The parent grant program is Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847).
Forecast synopsis
The purpose of this funding opportunity is to advance the NIH mission by supporting the continuation of the Consortium to Study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE).
Chronic Kidney Disease of Uncertain Etiology (CKDu) causes kidney failure in rural areas of many Low and Middle Income Countries, resulting in a large death toll among the young working age population. Environmental factors are suspected to be causative, but family and geographic clustering add consideration of unrecognized genetic susceptibility. The risk factors identified in other countries are encountered by U.S. patients, so this research will offer valuable insights into the development and progression of tubulointerstitial renal diseases, with broad implications for understanding kidney health and disease in the U.S.
NIDDK, NIEHS, and FIC have jointly funded a consortium that includes Field Epidemiology Sites, a Renal and Environmental Science Core, and a Data Coordinating Center to find causes and potential interventions for CKDu since 2021. This NOFO requests applications for the Renal and Environmental Science Core that will provide support and leadership in discovery science. Consortium members will continue to collaborate to maximize scientific opportunities and enable discovery science to understand the etiologies of CKDu, the exposures that initiate and affect progression of tubulointerstitial kidney disease, potential therapeutic targets, and future opportunities for public health interventions. The CURE Consortium will serve as a resource for ancillary studies.
This is a forecast for a single source Notice of Funding Opportunity (NOFO) that will invite application(s) from eligible organizations to apply. Application(s) will be peer-reviewed and only funded if meritorious.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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