Single Source: Cardiothoracic Surgical Trials Network (CTSN) Data Coordinating Center (U01 Clinical Trial Required)
Closed Posted
- Opportunity number
- RFA-HL-27-002
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Up to $8,000,000
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Other
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health National Heart, Lung, and Blood Institute is soliciting applications via cooperative agreement for a Data Coordinating Center to support the Cardiothoracic Surgical Trials Network, with applications due July 7, 2026. This is a single-source opportunity restricted to one eligible organization; applications will undergo peer review, and funding is contingent on merit.
The DCC comprises two collaborating components: a Data Management and Analytics Center (DMAC) and a Clinical Coordination Center (CCC). NHLBI strongly encourages multi-PD/PI applications with separate principal investigators leading each component. Primary responsibilities include overseeing conduct of multiple randomized clinical trials within CTSN, managing regulatory and administrative activities, collecting and analyzing data, reporting trial results, promoting collaboration among CTSN investigators and the broader research community, coordinating outreach to foundations and small businesses, integrating clinical sites and core laboratories, and conducting long-term telephone follow-up centrally. The DCC will manage a Clinical and Implementation Research Skills Program to train clinical trial and implementation research scholars, integrating clinical expertise with dissemination and implementation science.
The funding opportunity expands an existing international cardiac surgery research platform to encompass interventional cardiology, perioperative cardiac care, dissemination and implementation science, circadian medicine, and mechanistic science. The platform enables collaboration among academia, small businesses, professional societies, foundations, and international research entities to advance techniques, technologies, devices, pharmaceutical and bioengineered products targeting cardiovascular disease and associated neurologic complications.
The opportunity is assigned to multiple CFDA numbers: 93.837 (Cardiovascular Diseases Research), 93.838 (Lung Diseases Research), 93.840 (Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders), 93.839 (Blood Diseases and Resources Research), and 93.233 (National Center on Sleep Disorders Research).
Synopsis
This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite an application from the eligible organization to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application will be peer-reviewed, and if it is not a meritorious application, it will not be funded. This single source NOFO is intended to support a Data Coordinating Center (DCC) to conduct the activities of the Cardiothoracic Surgical Trials Network (CTSN). The DCC will consist of two collaborating components including a Data Management and Analytics Center (DMAC) and a Clinical Coordination Center (CCC). NHLBI strongly encourages multi-PD/PI applications with two PDs/PIs; one PD/PI for the DMAC and one PD/PI for the CCC. The primary responsibility of the DCC is to oversee the conduct of multiple randomized clinical trials in the CTSN.The DCC will support regulatory and administrative activities, data collection and management, and statistical analysis and reporting of trial results in a timely manner. The DCC will promote collaboration and communication among CTSN investigators and the broader research community and will coordinate outreach activities including engaging foundations, research entities, and small businesses in trials of mutual interest and public health importance. The DCC is responsible for integrating the efforts of clinical sites, core laboratories, and other collaborators, and conducting long-term follow-up centrally via telephone follow-up at the DCC. The NHLBI anticipates that the DCC will manage a Clinical and Implementation Research Skills Program centrally. The clinical and implementation research scholars program will support the expanded integration of clinical skills with dissemination and implementation science scholarship to enhance implementation research capacity. The scholars program would be designed to foster additional research questions within CTSN as well as generate a cohort of researchers who would transport their scholarship as they transition to leadership positions in academic and clinical programs.
Files
| File | Type | Posted |
|---|---|---|
| RFA-HL-27-002-Full-Announcement.html | HTML file |
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