Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0
Forecasted Federal grant Posted
- Opportunity number
- RFA-AR-26-006
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Higher Education Inst. (Private)
- Non-501(c)(3) Nonprofits
- State Governments
- Special District Governments
- Tribal Governments (Federally Recognized)
- City/Township Governments
- For Profit Organizations
- County Governments
- Higher Education Inst. (Public)
- Tribal Organizations (Not Federally Recognized)
- Public or Indian Housing Auth.
- Independent School Districts
- Small Businesses
- Other
- 501(c)(3) Nonprofits
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), in conjunction with other National Institutes of Health institutes as part of the congressionally mandated HEAL initiative, is forecasting a Notice of Funding Opportunity (NOFO) for the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0 cooperative agreement program; applications are not currently being solicited, and no specific deadline is present.
Eligible applicants include higher education institutions (public and private), 501(c)(3) nonprofits, non-501(c)(3) nonprofits, state and local governments, tribal governments (federally recognized and other), small businesses, for-profit organizations, public or Indian housing authorities, independent school districts, faith-based or community-based organizations, U.S. territories and possessions, foreign institutions, and eligible federal agencies.
The program aims to refine and map innervation of articular and peri-articular tissues (bone, cartilage, synovium, joint capsule, ligament, tendon, fascia, muscle) by sensory neurons mediating pain sensation. Priority activities include enhancing clinical pain phenotyping with multimodal profiling across expanded patient populations and disease conditions beyond knee and temporomandibular joint; expanding preclinical and New Approach Methodologies in joint disease modeling; preclinical testing of novel joint-targeted candidates from RE-JOIN 1.0; focusing on peri-articular tissues including vasculature, synovium, adipose, and myofascial tissue; and prioritizing secondary analysis of datasets and validation of methods in human samples. The program also emphasizes developing and enhancing joint atlases to integrate imaging and molecular datasets.
NIAMS is providing notice at the forecast stage to allow potential applicants sufficient time to develop multidisciplinary collaborations. Investigators with expertise in neurobiology, pain science, data science, orthopedics, and rheumatic disease are encouraged to prepare applications. The funding instrument is CFDA 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research).
Forecast synopsis
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), in conjunction with other NIH Institutes and Centers (ICs) as a part of the congressionally mandated NIH Helping to End Addiction Long Term (HEAL) initiative intends to publish a Notice of Funding Opportunity (NOFO) to leverage and accelerate the progress achieved in the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium.
The NOFO aims to more fully refine and map the innervation of the different articular and peri-articular tissues that collectively form the joint (including bone, cartilage, synovium, joint capsule, ligament, tendon, fascia and muscle), by sensory neurons that mediate the sensation of pain.
The NOFO seeks to expand initial and ongoing efforts by:
- Enhancing clinical pain phenotyping with multimodal profiling of new and expanded patient samples across life span and disease conditions (i.e., other musculoskeletal and/or rheumatic conditions associated with joint pain beyond knee and temporomandibular joint (TMJ)).
- Expanding to new preclinical and New Approach Methodologies (NAMs) in modeling joint disease.
- Preclinical testing of novel joint-targeted candidates identified in RE-JOIN 1.0.
- Focusing on peri-articular tissues in joint pain, such as vasculature, synovium, adipose, myofascial tissue, etc.
- Prioritizing secondary analysis of datasets and/or validation of methods and approaches in human samples.
- Improve data integration by developing/enhancing joint atlases that will enable integration of imaging and molecular datasets.
Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful multidisciplinary collaborations and responsive projects. Investigators with expertise and insights in neurobiology, pain science, data science, orthopedics, rheumatic disease, etc. are encouraged to consider applying for this NOFO.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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