Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

Open Posted

Opportunity number
RFA-OD-25-010
Agency
Applications due
Award size
Not on record

Opportunity facts

Assistance listings
Funding instrument
Grant
Category
  • Health
Eligible applicants
  • City/Township Governments
  • Other
  • Non-501(c)(3) Nonprofits
  • Higher Education Inst. (Private)
  • County Governments
  • Higher Education Inst. (Public)
  • For Profit Organizations
  • Tribal Governments (Federally Recognized)
  • State Governments
  • Small Businesses
  • 501(c)(3) Nonprofits
Points of contact

Opportunity details come from Grants.gov. Updated .

About this opportunity

Written by GovTribe AI ·

The National Institutes of Health Office of Research Infrastructure Programs (ORIP) is soliciting grant applications for developing, characterizing, or improving research models of human health and diseases; developing biology-based new approach methodologies (NAMs); or improving access to information about models of human disease, with applications due by September 28, 2028. Models and biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple organ systems. Applications to develop models relating strictly to a specific disease or select area of research, or that do not have broad impact on the NIH-wide research community, will not be accepted; projects predominantly addressing one NIH IC but only peripherally related to others will also be rejected.

Eligible applicants include higher education institutions (public and private), nonprofits (501(c)(3) and non-501(c)(3)), for-profit organizations, state and local governments, tribal governments, and federal agencies. Foreign organizations and non-domestic components of U.S. organizations are not eligible; foreign collaborations and foreign components are not allowed.

ORIP intends to fund at least six awards per fiscal year from 2026 through 2029, with up to $5 million annually available. Projects may be predominantly research-based if that research leads to development of tools or resources with broad biomedical impact, or aimed at final development or enhancement of existing resources. Funding supports developing informatics tools, generating mutant animal models, creating genetic resources, advancing stem cell techniques, and generating models for emerging pathogen research.

Applications utilize the R24 activity code (CFDA 93.351, Research Infrastructure Programs). Evaluation criteria assess scientific merit, technical adequacy, investigator competency, facility adequacy, budget necessity, and relevance to program objectives. The NOFO was updated December 24, 2025 to correct an IT issue.

Synopsis

The Office of Research Infrastructure Programs (ORIP) encourages grant applications aimed at developing, characterizing, or improving research models of human health and diseases; developing biology based new approach methodologies (NAMs) applicable to human health and diseases; or improving access to information about or generated from the use of models of human disease. The models, including NAMs, and related biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple organ systems in order to align with the ORIP"s NIH-wide mission and programs. Applications must describe the need for and the potential impact of the proposed resources on the research community across a range of scientific disciplines supported by multiple NIH ICs. Applications to develop models that relate strictly to a specific disease or a select area of research or that do not have a broad impact on the NIH-wide research community will not be accepted. Projects that predominantly address the research interests of one NIH IC but are only peripherally related to the research interests of other ICs will also not be accepted, if submitted in response to this notice of funding opportunity (NOFO).

Eligibility

Refer to Section III. Eligibility Information of the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Files

File Type Posted
RFA-OD-25-010-Revised-Full-Announcement.html HTML file
PKG00291722.pdf PDF
RFA-OD-25-010-Full-Announcement.html HTML file

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