Research Grants in Clinical Informatics (R01 Clinical Trial Optional)
Open Posted
- Opportunity number
- PAR-26-042
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Up to $250,000
Opportunity facts
- Assistance listings
-
- 93.879 Medical Library Assistance
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- 501(c)(3) Nonprofits
- For Profit Organizations
- Higher Education Inst. (Private)
- Higher Education Inst. (Public)
- Public or Indian Housing Auth.
- Tribal Governments (Federally Recognized)
- Independent School Districts
- Special District Governments
- State Governments
- Tribal Organizations (Not Federally Recognized)
- Non-501(c)(3) Nonprofits
- City/Township Governments
- Small Businesses
- Other
- County Governments
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Library of Medicine seeks applications for innovative research in clinical informatics with an application due date of March 5, 2029, and award budgets capped at $250,000 per year in direct costs with a maximum project period of 4 years. Eligible applicants include higher education institutions (public and private), nonprofits (501(c)(3) and non-501(c)(3)), for-profit organizations, state and local governments, tribal governments, and foreign organizations, provided that applications involving foreign subawards or subcontracts are not permitted and will be deemed noncompliant. Non-domestic components of U.S. organizations and unfunded international collaborations are allowed.
The program emphasizes domain-independent, scalable, and reusable approaches for the discovery, analysis, organization, and management of health-related digital objects including electronic health records, clinical notes, imaging data, and patient-generated data. Research must demonstrate potential to accelerate scientific insights, improve clinical workflows, and lead to improved health outcomes, with outputs expected to be transformative, broadly applicable, and sustainable. Interdisciplinary collaborations combining clinical informatics expertise with advances in data science, machine learning, and human-centered computing are encouraged.
Evaluation criteria include Importance of the Research (Significance and Innovation), Rigor and Feasibility (Approach), and Expertise and Resources. Awardees must develop data management and sharing plans, disseminate software and tools under open-access licenses, and submit annual research performance progress reports.
The program operates under CFDA 93.879 (Medical Library Assistance) using the R01 activity code. Applications open April 6, 2026, with recurring due dates of June 5, October 5, and February 5 on an ongoing basis through 2029. Applicants must register with SAM, obtain a Unique Entity Identifier, and register with eRA Commons and Grants.gov before submission.
Synopsis
The National Library of Medicine (NLM) seeks applications for innovative research in clinical informatics. The overarching goal of this forthcoming program is to catalyze the development and advancement of novel informatics methodologies that empower clinicians, patients, and the broader public to better understand, manage, and improve health and health care delivery. This NOFO will support research focused on the design, implementation, and evaluation of clinical informatics tools and methods that enable data-driven discovery, promote evidence-based decision-making, and support personalized and precision health care. Emphasis will be placed on domain-independent, scalable, and reusable/reproducible approaches for the discovery, analysis, organization, and management of health-related digital objects-including electronic health records (EHRs), clinical notes, imaging data, and patient-generated data. The aim is to transform raw and heterogeneous health data into actionable knowledge, to develop innovative tools, and to implement practical applications that can be generalized across multiple clinical settings and populations. Projects should demonstrate the potential to accelerate scientific insights, improve clinical workflows, and ultimately lead to improved health outcomes.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Files
| File | Type | Posted |
|---|---|---|
| PKG00291956.pdf | ||
| PAR-26-042-Full-Announcement.html | HTML file |
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