Rapid influenza testing with Cepheid XPert Flu in Emergency Department Practice
Closed Posted
- Opportunity number
- EP-IDS-14-017
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Other
- Full announcement
Opportunity details come from Grants.gov. Updated .
Synopsis
2 versions
Update #2 · Latest ·
NIH/NIAID, FDA/CDER and BARDA coordinate efforts to improve endpoints for clinical trials with new antivirals. Using endpoints originally established for clinical efficacy with oseltamivir has forced manufacturers to engage outpatient locations for enrollment of individuals with influenza-like-illness in large numbers, with very few individuals having complicated influenza that would benefit from antiviral treatment. The PHEMCE coordination has the goal to improve enrollment of high risk individuals such as those who present to the JHU Emergency Department, are identified as influenza virus positive by advanced rapid diagnostic testing, many of which are subsequently hospitalized. These patients can be treated early; thus providing a target population that can be more effectively monitored for clinical response to treatment.
Update #1 ·
The current cooperative agreement between ASPR and Johns Hopkins University (JHU) integrates rapid influenza molecular testing into Emergency Department (ED) clinical practice with assessment of clinical course following antiviral treatment and adoption of electronic communications that can assist clinicians and public health practice with local management of influenza infections. The existing JHU cooperative agreement (IDSEP130014) successfully completed one season of a clinical study across four EDs, enrolling 1,997 adult patients at 4 sites with over one-third hospitalized (also 592 admitted pediatric patients from two of the sites). The rapid influenza molecular test identified more than fifty adult influenza patients during their ED visit at two of these sites, many of which were hospitalized. During the second influenza season, adult patients presenting to the ED with potential symptoms of influenza will receive a rapid molecular influenza test during the triage process.
Eligibility
John Hopkins University, School of Medicine
Files
| File | Type | Posted |
|---|---|---|
| JHU FOA FINAL 09-19-14.pdf | ||
| JHU FOA FINAL 09-19-14.pdf |
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