Precision Approaches in Radiation Synthetic Combinations (PAIRS, RP1 Clinical Trial Optional)
Forecasted Federal grant Posted
- Opportunity number
- PAR-26-152
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
-
- 93.395 Cancer Treatment Research
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- For Profit Organizations
- Higher Education Inst. (Private)
- Non-501(c)(3) Nonprofits
- City/Township Governments
- Small Businesses
- Other
- County Governments
- Higher Education Inst. (Public)
- Independent School Districts
- Special District Governments
- Tribal Governments (Federally Recognized)
- State Governments
- 501(c)(3) Nonprofits
- Tribal Organizations (Not Federally Recognized)
- Public or Indian Housing Auth.
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Cancer Institute solicits research projects investigating actionable synthetic vulnerabilities paired with tumor responses to radiation therapy through the Precision Approaches in Radiation Synthetic Combinations (PAIRS) program, with a forecast status and no specified application deadline in this notice.
Eligible applicants include for-profit organizations, higher education institutions (public and private), 501(c)(3) and non-501(c)(3) nonprofits, small businesses, city and county governments, state governments, independent school districts, special district governments, tribal governments (federally recognized and non-federally recognized), public or Indian housing authorities, Indian or Native American tribal governments other than federally recognized, eligible federal agencies, U.S. territories or possessions, faith-based or community-based organizations, regional organizations, and non-domestic entities.
The program supports research developing radiation-synthetic combination strategies that exploit context-dependent vulnerabilities arising from tumor mutational landscapes and adaptive responses to radiation therapy. Research must demonstrate scientific rigor and reproducibility while leveraging radiation's clinical titratability through dose, schedule, and spatial targeting to design precision therapeutic strategies that enhance the therapeutic index by preferentially exploiting tumor-specific essentialities while sparing normal tissue. The NOFO consolidates prior exploratory, developmental, and research project funding opportunities.
This opportunity falls under CFDA 93.395, Cancer Treatment Research. Evaluation of applications includes assessment of scientific merit and significance, technical adequacy of experimental design, investigator competency, facility and resource adequacy, budget necessity, and relevance to program objectives. The National Cancer Institute administers peer review through scientific authorities and the National Cancer Advisory Board; all competitive applications compete for available funds based on scientific and technical merit, program relevance, and program balance aligned with NCI and NIH priorities.
Forecast synopsis
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits research projects that investigate actionable synthetic vulnerabilities that can be conditionally paired with tumor responses to radiation therapy. The goal of the Precision Approaches in Radiation Synthetic Combinations (PAIRS) program is to develop radiation-synthetic combination strategies and facilitate their adoption into the precision medicine toolkit toward building new and effective anticancer treatments. Early synthetic lethality-based therapeutic strategies in oncology primarily focused on targeting fixed mutations or genomic abnormalities. More recently, however, it has become clear that clinical benefit is often determined by context-dependent vulnerabilities arising from the intrinsic mutational landscape and adaptive tumor responses.
This NOFO is unique in its scope, supporting innovative cancer therapy strategies that explicitly exploit context-dependent effects of radiation therapy (RT) using drug-radiation combinations. The central premise of the PAIRS is that these conditional RT-induced responses can be leveraged to create or enhance actionable vulnerabilities that synergize with molecularly targeted agents for better outcomes. A defining feature of PAIRS is its emphasis on precision, scientific rigor, and reproducibility, aligned with NIH's scientific priorities. Radiation effects are clinically titratable through advances in delivery accuracy and flexibility, including dose, schedule, and spatial targeting. These capabilities enable the rational design of conditional RT-synthetic combination strategies that preferentially exploit tumor-specific essentialities while sparing normal tissues, thereby enhancing the therapeutic index by optimizing biological response. This NOFO consolidates the prior exploratory/developmental and research project funding opportunities to streamline the application process and maintain momentum in developing approaches that target actionable vulnerabilities within the defined radiation research scope. The applicants may submit either for exploratory/developmental research projects with a project period of up to 2 years or for research projects with a project period of 4 to 5 years.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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