Notice of Intent to Publish a Funding Opportunity Announcement for ClinGen Genomic Curation Expert Panels
Past Federal grant forecast Posted
- Opportunity number
- NOT-HD-25-006
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- County Governments
- Small Businesses
- Tribal Governments (Federally Recognized)
- Independent School Districts
- For Profit Organizations
- Higher Education Inst. (Private)
- Public or Indian Housing Auth.
- State Governments
- Tribal Organizations (Not Federally Recognized)
- Higher Education Inst. (Public)
- 501(c)(3) Nonprofits
- Points of contact
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- Julia Jiaqi O'Reilly jiaqi.oreilly@nih.gov (240) 328-8649
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health, through the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and seven co-funding institutes and centers, is soliciting applications for the establishment and continuation of Genomic Curation Expert Panels under a cooperative agreement mechanism; a Notice of Funding Opportunity has been forecasted but no specific application deadline is named in this notice of intent.
Eligible applicant types include county governments, state governments, tribal governments (federally recognized and not federally recognized), tribal organizations, for-profit organizations, small businesses, higher education institutions (public and private), independent school districts, public or Indian housing authorities, and 501(c)(3) nonprofits.
The Expert Panels will manually curate, review, and define the clinical relevance of genes and variants as part of the NIH-established Clinical Genome Resource (ClinGen). Panels are required to address genes and variants associated with diseases or conditions of high priority for participating institutes and centers. The panels must systematically determine clinical significance for diagnosis and treatment. All funded Expert Panels are required to utilize NHGRI ClinGen and NCBI ClinVar procedures, interfaces, tools, and informatics infrastructure. The resulting data contribute to an authoritative, centralized, and public resource for genetic conditions and causative variants.
The funding opportunity falls under CFDA 93.865 (Child Health and Human Development Extramural Research). Co-funding institutes include the National Eye Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute on Deafness and Other Communication Disorders, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences, and National Cancer Institute.
Forecast synopsis
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), with other NIH Institutes and Centers (ICs) - National Eye Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute on Deafness and Other Communication Disorders, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences, and National Cancer Institute - intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the establishment and continuation of Genomic Curation Expert Panels that manually curate, review and define the clinical relevance of genes and variants as part of the NIH established and funded Clinical Genome Resource (ClinGen). Despite advances in genomic sequencing technology and increasing adoption in clinical practice, there are many genomic variants with unknown significance (VUS), and there is limited understanding of their function. This presents barriers to genomic and precision medicine. To address this need for better knowledge about the links between genes, variants, and disease, this NOFO will facilitate the development of Expert Panels to select genes and variants associated with diseases or conditions of high priority for participating NIH Institutes and Centers (ICs) and to systematically determine their clinical significance for diagnosis and treatment of these diseases or conditions. The Expert Panels funded through this NOFO are required to utilize the NHGRI ClinGen and the NCBI ClinVar procedures, interfaces, tools, and informatics infrastructure. Ultimately, these expert panels contribute to an authoritative, centralized, and public resource, through aggregation, evaluation, and sharing of expert-curated data about genetic conditions, and the variants that cause them.
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