Mood and Psychosis Symptoms during the Menopause Transition (R01 Clinical Trial Optional)
Open Posted
- Opportunity number
- PAR-25-281
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Grant
- Category
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- Health
- Eligible applicants
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- Special District Governments
- Public or Indian Housing Auth.
- 501(c)(3) Nonprofits
- Tribal Organizations (Not Federally Recognized)
- State Governments
- Independent School Districts
- Higher Education Inst. (Public)
- Higher Education Inst. (Private)
- Tribal Governments (Federally Recognized)
- Small Businesses
- For Profit Organizations
- Other
- County Governments
- Non-501(c)(3) Nonprofits
- City/Township Governments
- Points of contact
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- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health, through the National Institute of Mental Health and the Office of Research on Women's Health, is soliciting applications for translational research on mood and psychosis symptoms during the menopause transition, with application due January 7, 2028.
Eligible applicants include higher education institutions (public and private), nonprofits (501(c)(3) and non-501(c)(3)), small businesses, for-profit organizations, state and local governments, tribal governments (federally and non-federally recognized), tribal organizations, special district governments, independent school districts, public and Indian housing authorities, and other entities. The NOFO also welcomes applications from Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions, HBCUs, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities, faith-based and community-based organizations, eligible federal agencies, regional organizations, non-domestic entities, and U.S. territories and possessions.
The program funds hypothesis-driven work advancing understanding of neurobiological and behavioral mechanisms underlying mood and psychotic disorders—including perimenopausal depression, generalized anxiety disorder, bipolar disorder, and schizophrenia—during the menopause transition. Priority research areas include classic depressive symptoms combined with menopause symptoms (hot flashes, night sweats, sleep disturbance), the role of reproductive steroids in mood and behavior regulation, diagnosis of mood and psychosis symptoms at menopausal stages, co-occurring psychiatric and menopause symptoms, psychosocial factors in midlife, and differential diagnoses. The program encourages interdisciplinary collaboration. Review criteria focus on the comprehensiveness of proposed neurobiology and mechanisms of action underlying mood and psychosis symptoms.
Funding is administered under CFDA 93.242 (Mental Health Research Grants) with co-funding participation from CFDA 93.313 (NIH Office of Research on Women's Health). Applications are evaluated by peer review panels for scientific and technical merit, program relevance, and program balance. Applicants must follow FORMS-I research-specific instructions and application guidelines.
Synopsis
The purpose of this Notice of Funding Opportunity (NOFO) is to advance translational research to better understand the emergence and worsening of mood and psychotic disorders (e.g., perimenopausal depression (PMD), generalized anxiety disorder, bipolar disorder and schizophrenia) during the menopause transition (MT) in an effort to identity targets for future development of novel treatment interventions. This funding opportunity aims to advance novel and innovative translational research to better comprehend the underlying neurobiological and behavioral mechanisms of mood and psychosis disorders and related symptoms during MT. This funding opportunity also encourages interdisciplinary researchers to collaborate on studies of mood and psychosis during the MT. Aspects of mood and psychosis disorders that are of interest include: classic depressive symptoms in combination with menopause symptoms (e.g., hot flashes, night sweats, sleep disturbance) and psychological challenges, the role of reproductive steroids in the regulation of mood and behavior during the MT, diagnosis of mood and psychosis symptoms at menopausal stage, investigation of co-occurring psychiatric and menopause symptoms, appreciation of psychosocial factors common in midlife, and differential diagnoses. Review criteria will focus on the comprehensiveness of the neurobiology and mechanisms of action underlying mood and psychosis symptoms and hypothesis-driven work.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-281-Full-Announcement.html | HTML file | |
| PKG00288958.pdf |
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