Metastasis Research Network (U54 Clinical Trial Not Allowed)
Closed Posted
- Opportunity number
- RFA-CA-27-012
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Up to $1,300,000
Opportunity facts
- Assistance listings
-
- 93.396 Cancer Biology Research
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- City/Township Governments
- Public or Indian Housing Auth.
- For Profit Organizations
- 501(c)(3) Nonprofits
- Higher Education Inst. (Public)
- Independent School Districts
- Higher Education Inst. (Private)
- Tribal Governments (Federally Recognized)
- Non-501(c)(3) Nonprofits
- Tribal Organizations (Not Federally Recognized)
- Special District Governments
- Other
- Small Businesses
- State Governments
- County Governments
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Cancer Institute solicits applications for U54 Specialized Centers within the Metastasis Research Network, with an application due date of September 25, 2026. Clinical trials are not allowed under this cooperative agreement.
Eligible applicants include higher education institutions (public and private), nonprofits (501(c)(3) and non-501(c)(3)), for-profit organizations, state and local governments, Indian tribal governments, and foreign organizations, provided they complete required registrations in SAM, eRA Commons, and Grants.gov. Non-domestic components of U.S. organizations and foreign components as defined in the NIH Grants Policy Statement are eligible.
NCI intends to commit $6.8 million in FY 2027 to fund approximately four awards. Each application is limited to $1.3 million per year in direct costs, with a maximum project period of five years. No cost share is specified.
Each MetNet Center must include an Administrative Core (required), a minimum of two Research Projects, and optionally a Shared Resource Core. Centers should propose an overarching scientific theme pursued through two or three inter- and multidisciplinary basic research projects using integrative system-level approaches to understand non-linear, dynamic, and emergent processes in metastasis. Overarching themes must encompass the interplay between at least two central elements in the metastatic process: early dissemination, cellular/soluble/physical microenvironment crosstalk, dormancy, or mechanisms of metastatic cell responses to therapies. Studies on all cancer types, including rare and pediatric metastatic cancers, are welcome.
Applications will be evaluated on scientific merit through peer review, with impact scores provided for the overall center and individual components. Reviewers assess significance, investigator qualifications, innovation, approach, environment, and integration of components into a cohesive research center.
The funding opportunity is identified as RFA-CA-27-012 under Assistance Listing 93.396 (Cancer Biology Research).
Synopsis
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on developing a comprehensive and cohesive understanding of cancer metastasis. Towards this goal, the NCI will support U54 Specialized Centers that together will continue to serve as the hub of the Metastasis Research Network (MetNet). Each MetNet Center should propose an overarching scientific theme that will be pursued through two or three scientific inter- and multidisciplinary basic research projects. The projects should use integrative system level approaches to elucidate and integrate a mechanistic understanding of the non-linear, dynamic, and emergent processes in metastasis. Overarching themes should encompass the interplay between at least two central elements in the metastatic process such as early dissemination, cellular, soluble and/or physical microenvironment crosstalk, dormancy, or mechanisms of responses by metastatic cells to therapies. Studies on all types of cancer are welcome, including rare and pediatric metastatic cancers.Research proposed by MetNet Centers is expected to advance our understanding towards a more comprehensive appreciation of metastasis as a whole body, systems-level problem.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Files
| File | Type | Posted |
|---|---|---|
| PKG00293063.pdf | ||
| RFA-CA-27-012-Full-Announcement.html | HTML file |
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