Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Therapeutic Agent Characterization and Preclinical Efficacy Studies
Past Federal grant forecast Posted
- Opportunity number
- PAR-26-057
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Independent School Districts
- 501(c)(3) Nonprofits
- Small Businesses
- For Profit Organizations
- City/Township Governments
- Special District Governments
- County Governments
- State Governments
- Other
- Tribal Governments (Federally Recognized)
- Tribal Organizations (Not Federally Recognized)
- Higher Education Inst. (Private)
- Public or Indian Housing Auth.
- Non-501(c)(3) Nonprofits
- Higher Education Inst. (Public)
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Neurological Disorders and Stroke, National Institute on Aging, NIH HEAL initiative, and other participating NIH institutes are forecasting a grant opportunity to support pharmacodynamic, pharmacokinetic, and efficacy studies demonstrating that proposed therapeutic agents possess sufficient biological activity to warrant further development as therapeutics for neurological and aging-related disorders or non-opioid analgesics with minimal addiction liability; applications are not being solicited at this time, and this notice provides advance visibility for applicants to develop collaborations.
Eligible applicants include independent school districts, 501(c)(3) nonprofits, small businesses, for-profit organizations, city and township governments, special district and county governments, state governments, federally recognized and non-federally recognized tribal governments and organizations, private and public higher education institutions, housing authorities, and non-501(c)(3) nonprofits. The opportunity also extends to eligible federal agencies, U.S. territory or possession entities, faith-based and community-based organizations, regional organizations, and non-domestic entities.
Therapeutic agents include small molecules or biologics. Efficacy testing may be conducted in validated in vivo models or validated New Approach Methodologies (NAMs) as appropriate. Research supported under this initiative falls under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
The forecast was posted February 25, 2026. No specific award ceiling, award floor, expected number of awards, cost share requirement, period of performance, or detailed evaluation criteria were provided in this notice.
Forecast synopsis
The National Institute of Neurological Disorders and Stroke, National Institute of Aging, the NIH Helping to End Addiction Long Term (HEAL) initiative, and other participating ICs seek to support applications to conduct pharmacodynamic, pharmacokinetic, and efficacy studies to demonstrate that the proposed therapeutic agent(s) have sufficient biological activity to warrant further development as therapeutics for disorders or diseases supported by participating ICs or for non-opioid analgesic therapeutics with little or no addiction liability as a part of the NIH HEAL initiative. Therapeutic agents include small molecules or biologics. Efficacy testing can be conducted in validated in vivo models and/or validated New Approach Methodologies (NAMs) as appropriate.
Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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