Impact of Initial Influenza Exposure on Immunity in Infants (U01 Clinical Trial Not Allowed)
Closed Posted
- Opportunity number
- RFA-AI-27-019
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Up to $3,000,000
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Higher Education Inst. (Private)
- City/Township Governments
- Tribal Governments (Federally Recognized)
- Higher Education Inst. (Public)
- Public or Indian Housing Auth.
- Tribal Organizations (Not Federally Recognized)
- Small Businesses
- Special District Governments
- County Governments
- Independent School Districts
- Other
- Non-501(c)(3) Nonprofits
- State Governments
- 501(c)(3) Nonprofits
- For Profit Organizations
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to fund longitudinal cohort studies examining how initial influenza exposures—through natural infection and/or vaccination—shape infant and childhood immunity, with the ultimate goal of facilitating the design of durable, broadly protective influenza vaccines. Applicants must establish or continue cohorts of infants and/or mother-infant dyads followed prior to and after initial influenza vaccination or documented clinical influenza infection, with enrollment ideally occurring between birth and prior to initial exposure. The research must address two mandatory topics: determining the effects of repeated exposures on maintenance and evolution of influenza-specific humoral and T cell-mediated immunity, and comparing immune mechanisms elicited by vaccination versus natural infection. Cohorts must be followed for at least three influenza seasons, with inclusion of pregnant women and post-partum mothers strongly encouraged. Evaluation will be based on scientific merit and significance, technical adequacy of experimental design, investigator competency, adequacy of facilities and resources, and budget appropriateness. The application deadline is June 4, 2026, with the earliest start date of June 4, 2026.
NIAID intends to commit $9.6 million in FY 2027 to fund 2-4 awards through a cooperative agreement mechanism (U01), with individual award budgets not expected to exceed $3 million in direct costs per year and a maximum project period of five years. Awardees must budget for attendance at a kick-off meeting in Year 1 and annual two-day program meetings in Bethesda, Maryland beginning in Year 2, as well as at least $100,000 annually beginning in Year 2 for an Opportunity Fund supporting pilot projects. Research will be conducted at eligible applicant institutions, including higher education institutions (public and private), nonprofits, for-profit organizations, state and local governments, and tribal governments, with performance occurring at the applicant's designated research facilities.
Synopsis
The purpose of this notice of funding opportunity (NOFO) is to support the establishment or continuation of longitudinal infant cohorts to determine and compare how initial and repeated natural influenza infections and/or influenza vaccinations shape infant and childhood immunity to future influenza exposures. The goal of this research is to understand how these exposures influence immune responses to subsequent influenza infections and/or vaccines and provide key information to facilitate design of durable, broadly protective influenza vaccines.
Files
| File | Type | Posted |
|---|---|---|
| RFA-AI-27-019-Full-Announcement.html | HTML file |
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