Impact of Immunotherapies on CNS Outcomes in People with HIV: Potential Benefits, Challenges and Risks
Past Federal grant forecast Posted
- Opportunity number
- RFA-MH-27-110
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Non-501(c)(3) Nonprofits
- Other
- Independent School Districts
- Tribal Governments (Federally Recognized)
- Special District Governments
- Higher Education Inst. (Private)
- For Profit Organizations
- State Governments
- Tribal Organizations (Not Federally Recognized)
- City/Township Governments
- Higher Education Inst. (Public)
- County Governments
- Public or Indian Housing Auth.
- Small Businesses
- 501(c)(3) Nonprofits
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Mental Health is soliciting applications to evaluate the impact of HIV immunotherapies on central nervous system outcomes in people with HIV, with no application due date currently posted pending formal NOFO publication.
Eligible applicants include non-501(c)(3) nonprofits, 501(c)(3) nonprofits, higher education institutions (public and private), for-profit organizations, small businesses, state and local governments, county and township governments, independent school districts, tribal governments (federally and non-federally recognized), tribal organizations, special district governments, public or Indian housing authorities, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
The program will use the R21/R33 biphasic activity code, supporting research that generates evidence on whether HIV immunotherapies can safely and effectively target CNS HIV persistence while minimizing neurotoxicity and neuroinflammation. The research must address CNS-specific barriers including blood-brain barrier penetration, compartmentalized viral dynamics, and immune-mediated effects, with the goal of developing strategies that contribute to sustained virologic remission across anatomical compartments and improve long-term neurologic and cognitive outcomes in people with HIV.
All applications undergo scientific and technical merit review by peer review panels; non-fellowship applications also receive review by the National Advisory Mental Health Council. Funding decisions rest on technical merit, availability of funds, and relevance to program priorities. The parent grant program is Mental Health Research Grants (CFDA 93.242). Project periods do not exceed five years, and awards are subject to OMB 2 CFR 200 audit requirements.
Forecast synopsis
The National Institute of Mental Health (NIMH) intends to publish a notice of funding opportunity (NOFO) to solicit biphasic research applications to evaluate the impact of HIV immunotherapies on central nervous system (CNS) outcomes in people with HIV and to identify mechanisms, benefits, and risks associated with their use in the CNS compartment. The primary goal is to generate evidence that informs whether HIV immunotherapies can safely and effectively target CNS HIV persistence while minimizing neurotoxicity and neuroinflammation. By addressing CNS-specific barriers such as blood brain barrier penetration, compartmentalized viral dynamics, and immune-mediated effects, this NOFO will support the development of strategies that contribute to sustained virologic remission across anatomical compartments and improve long-term neurologic and cognitive outcomes in people with HIV. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into the impact of HIV immunotherapies on the CNS and viral reservoirs are strongly encouraged to apply to this new NOFO. This NOFO will utilize the R21/R33 activity code.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;
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