Illuminating AD/ADRD Genome to Enable Precision Genomic Medicine
Past Federal grant forecast Posted
- Opportunity number
- RFA-AG-26-023
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
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- 93.866 Aging Research
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- State Governments
- County Governments
- City/Township Governments
- For Profit Organizations
- Independent School Districts
- Higher Education Inst. (Private)
- Higher Education Inst. (Public)
- Other
- Public or Indian Housing Auth.
- Tribal Organizations (Not Federally Recognized)
- 501(c)(3) Nonprofits
- Non-501(c)(3) Nonprofits
- Tribal Governments (Federally Recognized)
- Small Businesses
- Special District Governments
- Points of contact
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- Alison Yao yaoal@nia.nih.gov (301) 827-7264
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute on Aging is forecasting a Notice of Funding Opportunity (NOFO) to solicit cooperative agreement applications for integrative, cross-disciplinary projects aimed at scaling mechanistic studies to understand the genomic underpinnings of Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD), with no hard deadline specified as applications are not being solicited at this time. This notice provides potential applicants time to develop collaborations and responsive projects in advance of the formal solicitation.
Eligible applicant categories include state and local governments, higher education institutions (public and private), nonprofit and for-profit organizations, tribal governments (federally and non-federally recognized), small businesses, Indian housing authorities, special district governments, independent school districts, faith-based and community-based organizations, regional organizations, eligible federal agencies, U.S. territories and possessions, and non-domestic entities.
The proposed research employs interdisciplinary approaches integrating innovative techniques to dissect genomic drivers of AD/ADRD through advanced analytical methods including machine learning and comparative genomic analysis across multiple genetic ancestries or neurodegenerative diseases. Studies will leverage cutting-edge tools such as genome editing, functional characterization assays, and emerging single-cell and spatial omics technologies. Projects will use sophisticated disease models including human stem cell-based systems, ex vivo models, in vivo models reflecting different genetic ancestries, various model organisms, or multiple neurodegenerative conditions. The initiative aims to identify actionable therapeutic targets for AD/ADRD to guide precision medicine approaches.
The funding instrument is a U01 cooperative agreement under Assistance Listing 93.866 (Aging Research). The National Advisory Council on Aging provides secondary review of applications. Standard NIH review timelines apply, with award decisions typically rendered within six to nine months of application submission.
Forecast synopsis
The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications that propose a program that supports integrative, cross-disciplinary projects aimed at scaling up mechanistic studies to understand the genomic underpinnings of the pathogenesis and progression AD/ADRD.
The proposed research projects will employ interdisciplinary approaches that integrate innovative techniques to dissect the genomic drivers of AD/ADRD. These projects will leverage advanced analytical methods, including machine learning and comparative genomic analysis across multiple genetic ancestries or multiple neurodegenerative diseases, along with cutting-edge tools like genome editing, functional characterization assays, and emerging single-cell and spatial omics technologies. These studies will use sophisticated disease models, such as human stem cell-based systems, ex vivo, and in vivo models that reflect different genetic ancestries, various model organisms, or multiple neurodegenerative conditions. These cross-ancestry, cross-disease, and cross-species approaches will enable a more comprehensive investigation of the genomic drivers of neurodegeneration and neuropathogenesis. Ultimately, this initiative may lead to the identification of actionable therapeutic targets for AD/ADRD, meeting the urgent need for mechanism-driven insights that can guide precision medicine approaches for its treatment.
Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO intends to utilize the U01 activity code. Investigators with expertise and insights into this area of aging research are encouraged to begin to consider applying for this new NOFO.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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