HEAL Initiative: Optimization of Therapeutic Medical Devices through Team Science Mechanistic Research (RM1)
Past Federal grant forecast Posted
- Opportunity number
- RFA-NS-26-028
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- County Governments
- 501(c)(3) Nonprofits
- Tribal Governments (Federally Recognized)
- Small Businesses
- Non-501(c)(3) Nonprofits
- Other
- For Profit Organizations
- State Governments
- Special District Governments
- City/Township Governments
- Tribal Organizations (Not Federally Recognized)
- Higher Education Inst. (Public)
- Independent School Districts
- Public or Indian Housing Auth.
- Higher Education Inst. (Private)
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Neurological Disorders and Stroke (NINDS), with other NIH Institutes and Centers, is forecasting a Notice of Funding Opportunity to support interdisciplinary team research on the mechanisms by which therapeutic medical devices produce clinical effects, with no current application deadline specified. This is a forecast only; applications are not being solicited at this time.
Eligible applicants include county governments, state governments, city and township governments, tribal governments (federally recognized and non-federally recognized), special district governments, public and private higher education institutions, independent school districts, public or Indian housing authorities, 501(c)(3) nonprofits, non-501(c)(3) nonprofits, small businesses, for-profit organizations, faith-based or community-based organizations, regional organizations, federal government agencies, U.S. territories or possessions, and non-domestic entities.
The program targets mechanistic research on both investigational devices and FDA-approved devices currently in clinical use. Supported research may include mechanistic clinical trials, animal studies, and computational modeling or simulation. Applicant teams should demonstrate interdisciplinary expertise spanning engineering, biology, pathophysiology, surgery, clinical care, healthcare delivery, biostatistics, software development, computational modeling, artificial intelligence, regulatory science, and clinical trials. The overarching goal is to improve clinical outcomes with device-based approaches by identifying physiological markers of neurological conditions and assessing how device therapies influence those markers.
Applications will be reviewed on scientific merit, technical adequacy of experimental design, investigator competency, facility and resource adequacy, budget necessity, and relevance to program objectives. This opportunity is funded under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
Forecast synopsis
The National Institute of Neurological Disorders and Stroke (NINDS), with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to investigate the mechanisms of action of therapeutic medical devices with the overall goal of improving clinical outcomes with device-based approaches. Medical devices are essential in managing health conditions, complementing drugs and behavioral interventions, and often offer unique benefits. Despite the commercial availability of numerous medical devices and ongoing development of new technologies, many have shown inconsistent results in preclinical studies, failed translation to humans, and exhibit varied patient outcomes. To overcome these challenges, it is crucial to understand the mechanisms by which medical devices produce a therapeutic effect, to identify physiological markers of neurological conditions, and to assess how device-based therapies influence these markers. Advancing this knowledge will improve device-based interventions, inspire new device designs, and optimize current clinical approaches.
Applications will be invited from interdisciplinary teams pursuing innovative research on how medical devices produce a therapeutic effect. Applicant teams will likely exhibit expertise in areas such as engineering, biology, pathophysiology, surgery, clinical care, healthcare delivery, biostatistics, software development, computational modeling, artificial intelligence, regulatory science, and clinical trials. This program will accept projects on investigational devices and those already FDA-approved and in clinical use. Applications are expected to include strategies for developing or optimizing therapies that could significantly improve patient care. Supported research may include mechanistic clinical trials, animal studies, and computational modeling or simulation. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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