Funding Opportunity Announcement for Impact of Environmental Exposures on Gut-Brain Signaling in Neurological Conditions (R01)
Past Federal grant forecast Posted
- Opportunity number
- TEMP-31126
- Agency
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National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
-
- 93.113 Environmental Health
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- County Governments
- Public or Indian Housing Auth.
- For Profit Organizations
- Tribal Organizations (Not Federally Recognized)
- Tribal Governments (Federally Recognized)
- Independent School Districts
- 501(c)(3) Nonprofits
- Higher Education Inst. (Public)
- Other
- Small Businesses
- Higher Education Inst. (Private)
- State Governments
- Points of contact
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- Anika L. Dzierlenga anika.dzierlenga@nih.gov (984) 287-3125
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Environmental Health Sciences (NIEHS) is forecasting a Notice of Funding Opportunity to solicit R01 grant applications for research on environmental exposures and their impact on the gut-brain axis in neurological disease, with applications not yet open for submission.
Eligible applicants include higher education institutions (public and private), state and county governments, tribal governments (federally recognized and not), for-profit and nonprofit organizations, small businesses, independent school districts, and housing authorities. NIEHS will allow foreign components as defined in the NIH Grants Policy Statement.
The program aims to build understanding of how environmental exposures affect gut microbiome-brain signaling to identify improved detection, prevention, and intervention strategies for environmental exposure-induced neurological diseases. Target conditions include mental health disorders and chronic neurodegenerative conditions such as Parkinson's disease and Alzheimer's disease. Applicants should develop gut-focused intervention strategies such as probiotics, microbial biomarkers, nutritional supplements, and novel therapeutics to decrease risk, slow progression, or reverse these conditions. NIEHS will particularly encourage collaborative investigations combining expertise in toxicology, microbiome, and neuroscience.
Awards fall under CFDA 93.113 (Environmental Health). Recent R01 awards under this program typically range from $200 thousand to $800 thousand annually. Receipt, review, and approval processes range from six to nine months. Peer review follows a dual-track model: scientific merit assessment by study section, followed by advisory council review. Evaluation emphasizes scientific significance, technical adequacy of experimental design, investigator competency, facility adequacy, budget justification, and relevance to program objectives. Applications remain in forecast status; NIEHS has indicated this opportunity will allow potential applicants sufficient time to develop meaningful collaborations and responsive projects before the formal NOFO is published.
Forecast synopsis
The National Institute of Environmental Health Sciences (NIEHS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research that builds on our understanding of the gut microbiome-brain axis for the purpose of identifying improved detection, prevention, and intervention strategies for environmental exposure-induced neurological diseases. Given the overlapping gut-brain signaling pathways and the prevalence of neurological conditions with gut-related comorbidities, the scope of this program would be inclusive of a wide range of neurological outcomes, including mental health disorders and chronic neurodegenerative conditions such as Parkinson's disease and Alzheimer's disease. The objective of this program is to develop gut-focused intervention strategies (e.g., probiotics, microbial biomarkers, nutritional supplements and novel therapeutics) to decrease risk, slow progression, or possibly reverse these neurological condition(s). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise and insights into this area of biological mechanisms underlying the effects of environmental exposures on neurological outcomes and the mediating role of the gut-brain axis are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in toxicology, microbiome, and neuroscience will be encouraged and these investigators should also begin considering applying for this application.
Eligibility
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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