Forecast to Publish a Funding Opportunity Announcement for Copy of Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia Administrative Resource Core (U24) (Clinical Trial Optional)

Past Federal grant forecast Posted

Opportunity number
NOT-AA-25-009
Agency
Applications expected due
Award size
Not on record

Opportunity facts

Expected posting
Assistance listings
Funding instrument
Cooperative Agreement
Category
  • Health
Eligible applicants
  • State Governments
  • Higher Education Inst. (Private)
  • Higher Education Inst. (Public)
  • Tribal Organizations (Not Federally Recognized)
  • 501(c)(3) Nonprofits
  • For Profit Organizations
  • Independent School Districts
  • Tribal Governments (Federally Recognized)
  • Small Businesses
  • Public or Indian Housing Auth.
  • County Governments
Points of contact

Opportunity details come from Grants.gov. Updated .

About this opportunity

The National Institutes of Health is forecasting a funding opportunity announcement to support renewal of the Integrative Neuroscience Initiative on Alcoholism (INIA) through cooperative agreements; applications are not yet being solicited, but notice is provided to allow potential applicants time to develop meaningful collaborations. The initiative will support two collaborative research consortia through open competition, with no application deadline currently set.

Eligible applicants include state governments, public and private higher education institutions, tribal governments (both federally recognized and not federally recognized), 501(c)(3) nonprofits, for-profit organizations, independent school districts, small businesses, and public or Indian housing authorities.

The INIA renewal will fund two multisite consortia, each comprising administrative and resource cores plus individual research project grants (U01s), to study brain-body homeostatic dysregulation that promotes excessive alcohol drinking and Alcohol Use Disorder (AUD) phenotypes. Research will emphasize hypothesis-centered investigation of interactions between alcohol and other causal influences, with focus on trajectories from initial alcohol exposure to pathological drinking development. The initiative promotes adaptation of advanced tools and technologies from the BRAIN Initiative and NIH Common Fund to examine brain structure and function across multiple spatial and temporal scales, from microcircuitry to whole-brain networks, and assess peripheral influences on brain function underlying excessive alcohol drinking. Standardization of neurofunctional measures and replication across consortia will support rigor and reproducibility. Integration occurs through multisite projects addressing shared central hypotheses, knowledge of actions across biological scales, shared resources and standardized protocols, and cross-species translation.

The opportunity is assigned to Assistance Listing 93.273 (Alcohol Research Programs) under the National Institute on Alcohol Abuse and Alcoholism.

Forecast synopsis

The purpose is to renew the NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA). The INIA renewal will support two collaborative research consortia through an open competition to study brain-body homeostatic dysregulation that promotes and perpetuates excessive alcohol drinking and related Alcohol Use Disorder (AUD) phenotypes. We encourage hypothesis-centered research on interactions between alcohol and other relevant causal influences. Focus on trajectories from initial alcohol exposure to the development of pathological drinking by some individuals will identify translatable markers and mechanisms to support future prevention and intervention efforts that reduce the chronic conditions associated with alcohol misuse including but not limited to AUD. To promote innovation, investigators will adapt advanced tools and technologies from the BRAIN Initiative, NIH Common Fund, and other sources to examine brain structure and function at multiple spatial and temporal scales, from microcircuitry to whole brain networks, and reveal peripheral influences on brain function underlying excessive alcohol drinking. To promote rigor and reproducibility, a focus on standardization of neurofunctional measures and replication will be instituted across both consortia. In the context of the initiative, integration occurs with: (1) projects across multiple participating sites addressing objectives around a central hypothesis, (2) knowledge of actions and interactions at multiple biological scales of analysis, (3) shared resources and standardized experimental protocols, and (4) cross-species translation. The initiative renewal will support two collaborating multisite consortia though cooperative agreement mechanisms, each comprised of administrative and resource cores, and U01s for individual research projects. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of integrative neuroscience are encouraged to begin to consider applying for this new NOFO.

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