Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required)

Open Posted

Opportunity number
PAR-25-274
Agency
Applications due
Award size
Not on record

Opportunity facts

Funding instrument
Grant
Category
  • Health
Eligible applicants
  • City/Township Governments
  • Small Businesses
  • Special District Governments
  • Higher Education Inst. (Private)
  • Higher Education Inst. (Public)
  • Tribal Organizations (Not Federally Recognized)
  • Non-501(c)(3) Nonprofits
  • Other
  • County Governments
  • For Profit Organizations
  • 501(c)(3) Nonprofits
  • Tribal Governments (Federally Recognized)
  • Public or Indian Housing Auth.
  • State Governments
  • Independent School Districts
Points of contact
Full announcement

Opportunity details come from Grants.gov. Updated .

About this opportunity

Written by GovTribe AI ·

The National Institutes of Health National Center for Complementary and Integrative Health (NCCIH) is soliciting applications for feasibility clinical trials of mind and body interventions addressing NCCIH high-priority research topics, with applications due November 17, 2026.

Eligible applicants include higher education institutions (public and private), 501(c)(3) and non-501(c)(3) nonprofits, small businesses, for-profit organizations, state and county governments, tribal governments (federally and non-federally recognized), tribal organizations, city and township governments, special district governments, public or Indian housing authorities, and independent school districts. Non-domestic entities and foreign components, as defined in the NIH Grants Policy Statement, are not eligible, though foreign components within U.S. organizations are permitted.

This R34 mechanism supports feasibility trials that generate scientific knowledge necessary to design and conduct a subsequent full-scale clinical efficacy, effectiveness, pragmatic, or dissemination and implementation trial. Applicants must describe the planned future clinical trial and demonstrate that the proposed feasibility research is scientifically necessary to plan the full-scale trial. Data collection should address gaps including examination of intervention feasibility and acceptability where published data are lacking, tailoring interventions to specific populations or settings, refining intervention frequency or duration, determining feasibility of recruitment and retention procedures, assessing protocolized multi-component interventions, and evaluating acceptability and adherence of control conditions. The subsequent full-scale trial must have potential to make significant public health impact.

Applications are subject to two-stage peer review using standard NIH merit criteria: scientific innovation and significance, technical adequacy of design, investigator competency, facility adequacy, budget justification, and program relevance. A Plan for Enhancing Diverse Perspectives (PEDP) is required. Applicants are encouraged to contact the appropriate NCCIH Scientific/Research contact prior to submission. The program operates under CFDA 93.213.

Synopsis

2 versions

Update #2 · Latest ·

The goal of this notice of funding opportunity (NOFO) is to support feasibility trials of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions) for conditions that have been identified by NCCIH as high-priority research topics. This funding opportunity is intended to support feasibility clinical trials that provide new information that are scientifically necessary for the planning and conduct of a subsequent clinical efficacy or effectiveness study, pragmatic trial, or dissemination and implementation trial within NCCIHs mission. NCCIH expects that applications to this NOFO will describe the planned future clinical trial and in so doing demonstrate that the proposed (R34) research is scientifically necessary to design or plan the subsequent competitive full-scale clinical trial. Under this R34, the data collected should be used to fill gaps in scientific knowledge necessary to develop a competitive full-scale clinical trial, including, but not limited to the following: examining feasibility and acceptability of interventions lacking published data; tailoring or adapting the content or structure of an intervention to a specific population, modality, or setting; refining the intervention to determine the most appropriate frequency or duration; determining feasibility of recruitment, retention, and data collection procedures; refining and assessing the feasibility of protocolized multi-component interventions; or examining acceptability and adherence of control conditions. The subsequent full-scale clinical trial should have the potential to make a significant impact on public health. Prior to submitting to this NOFO, applicants are encouraged to contact the appropriate NCCIH Scientific/Research contact person for the science area of the planned application.

Update #1 ·

The goal of this notice of funding opportunity (NOFO) is to support feasibility trials of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions) for conditions that have been identified by NCCIH as high-priority research topics. This funding opportunity is intended to support feasibility clinical trials that provide new information that are scientifically necessary for the planning and conduct of a subsequent clinical efficacy or effectiveness study, pragmatic trial, or dissemination and implementation trial within NCCIHs mission. NCCIH expects that applications to this NOFO will describe the planned future clinical trial and in so doing demonstrate that the proposed (R34) research is scientifically necessary to design or plan the subsequent competitive full-scale clinical trial. Under this R34, the data collected should be used to fill gaps in scientific knowledge necessary to develop a competitive full-scale clinical trial, including, but not limited to the following: examining feasibility and acceptability of interventions lacking published data; tailoring or adapting the content or structure of an intervention to a specific population, modality, or setting; refining the intervention to determine the most appropriate frequency or duration; determining feasibility of recruitment, retention, and data collection procedures; refining and assessing the feasibility of protocolized multi-component interventions; or examining acceptability and adherence of control conditions. The subsequent full-scale clinical trial should have the potential to make a significant impact on public health. Prior to submitting to this NOFO, applicants are encouraged to contact the appropriate NCCIH Scientific/Research contact person for the science area of the planned application. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP).

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Files

File Type Posted
PKG00288883.pdf PDF

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