Exposomic Contributions to ADRD Pathology and Resilience
Past Federal grant forecast Posted
- Opportunity number
- RFA-NS-26-031
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Public or Indian Housing Auth.
- Independent School Districts
- Tribal Organizations (Not Federally Recognized)
- Higher Education Inst. (Public)
- City/Township Governments
- County Governments
- State Governments
- Small Businesses
- Non-501(c)(3) Nonprofits
- Tribal Governments (Federally Recognized)
- Special District Governments
- For Profit Organizations
- Higher Education Inst. (Private)
- Other
- 501(c)(3) Nonprofits
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Neurological Disorders and Stroke (NINDS) is forecasting support for research projects investigating how neural exposome factors contribute mechanistically to Alzheimer's disease-related dementias (ADRD) pathology and resilience; applications are not currently being solicited, with no hard deadline specified.
Eligible applicants include public and private higher education institutions, state and local governments, tribal organizations (federally and non-federally recognized), small businesses, for-profit and non-profit organizations, Indian housing authorities, independent school districts, special district governments, U.S. territories, faith-based and community-based organizations, regional organizations, federal agencies, and non-domestic entities.
Exposome factors of interest include environmental toxins, sleep and circadian rhythms, stress, and real-world conditions that modulate them such as light, noise, and heat. Applications must propose research on synergistic action between multiple exposome factors and composite effects of exposome mixtures on neural mechanisms relevant to ADRD. Applicants are encouraged to focus on mechanistic pathways including microbiome-brain interactions, neuroimmune signaling, and epigenetic modifications linking exposures to ADRD risk, progression, and resilience. Studies covering the lifespan, including critical or sensitive exposure periods and factors contributing to neurological health disparities, are encouraged. Mechanistic, translational, and human subjects research drawing on clinical data, human samples, and observational or interventional studies are acceptable; NIH-defined clinical trials are not supported. Investigative teams with expertise in exposomics, environmental neuroscience, community engagement, ADRD mechanisms, and non-medical factors contributing to health disparities are encouraged to apply.
The program operates under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders). Evaluation emphasizes scientific merit, technical adequacy, investigator competency, facility adequacy, budget necessity, and relevance to program objectives. Research grant applications requesting $500,000 or more in direct costs annually require prior NINDS approval.
Forecast synopsis
The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting research projects that investigate how specific neural exposome factors contribute mechanistically to Alzheimer's disease-related dementias (ADRD) pathology and resilience. For the purposes of this program, exposome factors of interest include, but are not limited to, environmental toxins, sleep and circadian rhythms, stress, and the real-world conditions that modulate them (e.g., light, noise, heat).
Applications will be expected to propose research on the synergistic action between multiple exposome factors, and the composite effects of mixtures of exposome factors on neural mechanisms relevant to ADRD. Applicants are encouraged to focus on mechanistic pathways (e.g., microbiome-brain interactions, neuroimmune signaling, epigenetic modifications) that link exposures to ADRD risk, progression, and resilience. Applicants are further encouraged to consider studies that cover the lifespan, including work that investigates critical or sensitive periods of exposure or factors that may lead to neurological health disparities. Applicants may propose mechanistic, translational, and/or human subjects research, drawing on clinical data, human samples, and observational or interventional studies. However, NIH-defined clinical trials will not be supported under this program.
Applications are not currently being solicited. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigative teams with expertise in exposomics and environmental neuroscience, community engagement, ADRD mechanisms, and non-medical factors that may lead to health disparities are encouraged to apply.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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