Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)

Open Posted

Opportunity number
RFA-CA-27-019
Agency
Applications due
Award size
$50,000 to $300,000

Opportunity facts

Funding instrument
Cooperative Agreement
Category
  • Health
Eligible applicants
  • County Governments
  • Independent School Districts
  • Tribal Governments (Federally Recognized)
  • Small Businesses
  • Other
  • For Profit Organizations
  • Special District Governments
  • 501(c)(3) Nonprofits
  • City/Township Governments
  • Tribal Organizations (Not Federally Recognized)
  • Non-501(c)(3) Nonprofits
  • Higher Education Inst. (Public)
  • Public or Indian Housing Auth.
  • Higher Education Inst. (Private)
  • State Governments

Opportunity details come from Grants.gov. Updated .

About this opportunity

Written by GovTribe AI ·

The National Cancer Institute seeks applicants for Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01, Clinical Trial Optional), a cooperative agreement funding informatics tools to improve data acquisition, management, analysis, and dissemination across the cancer research continuum, with applications due October 19, 2026.

Eligible applicants include higher education institutions (public and private), nonprofits (501(c)(3) and non-501(c)(3)), for-profit organizations, state and local governments, tribal governments (federally recognized and not federally recognized), county governments, special district governments, independent school districts, and public or Indian housing authorities. Foreign organizations may apply; foreign subawards and subcontracts are not permitted.

NCI intends to commit $2.4 million in FY 2027 to fund an estimated 5 awards. Individual awards are limited to $300,000 in direct costs per year with a maximum three-year project period. Early-stage development is defined as initial tool development or significant modification of existing tools for new applications. Applicants must set aside 10 percent of their annual budget in Budget Period 2 and beyond for collaborative activities and include travel support for annual ITCR Program meetings.

All proposed projects must demonstrate potential to advance cancer research projects and the field generally, deliver novel informatics capabilities for the targeted research domain, include compelling plans and processes for engaging end users throughout development, and provide realistic timelines with milestones. Required submissions include a Data Management and Sharing Plan and Software and Model Sharing Plan, with machine learning models requiring detailed model card annotations.

Review criteria emphasize scientific merit, innovation, rigor, feasibility, investigator expertise, and institutional resources. The funding opportunity encompasses CFDA codes 93.393 (Cancer Cause and Prevention Research), 93.394 (Cancer Detection and Diagnosis Research), 93.395 (Cancer Treatment Research), 93.396 (Cancer Biology Research), and 93.399 (Cancer Control). Peer review is scheduled for November 2026, advisory council review for January 2027, with earliest project start date of April 2027.

Synopsis

This Notice of Funding Opportunity (NOFO) solicits applications for the development of enabling informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and prevention, cancer control and epidemiology. As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Program, this NOFO is focused on early-stage development from prototyping to initial dissemination. Early-stage development is defined for the purpose of this NOFO as initial tool development or the significant modification of existing tools for new applications. The central mission of ITCR is to promote research-driven informatics technology across the development lifecycle to address priority needs in cancer research. In order to be successful, proposed development plans must have a clear rationale for why the proposed technology is needed and how it will benefit the cancer research field. In addition, mechanisms to solicit feedback from driving research projects and other users throughout the development process must be included.This NOFO encourages applications that involve the development of new, user-friendly informatics technologies that support a wide range of cancer research, including discovery biology, population studies, as well as clinical and translational research. The emphasis is on uniqueness and potential impact on cancer research. In addition, all projects proposed in response to this NOFO must involve the following general attributes:Potential to advance driving cancer research projects and the cancer research field in generalNovel informatics capabilities for the targeted cancer research domainCompelling plans and processes for engaging end users to evaluate and apply the tool or resourceA realistic timeline and milestones for technology development

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Files

File Type Posted
PKG00292873.pdf PDF
RFA-CA-27-019-Full-Announcement.html HTML file

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