Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed)

Forecasted Federal grant Posted

Opportunity number
PAR-29-002
Agency
Applications expected due
Award size
$190,000 to $500,000

Opportunity facts

Expected posting
Assistance listings
Funding instrument
Grant
Category
  • Health
Eligible applicants
  • Special District Governments
  • Tribal Organizations (Not Federally Recognized)
  • Tribal Governments (Federally Recognized)
  • State Governments
  • Small Businesses
  • County Governments
  • Higher Education Inst. (Private)
  • Independent School Districts
  • Other
  • 501(c)(3) Nonprofits
  • Non-501(c)(3) Nonprofits
  • Higher Education Inst. (Public)
  • City/Township Governments
  • Public or Indian Housing Auth.
  • For Profit Organizations
Points of contact

Opportunity details come from Grants.gov. Updated .

About this opportunity

The National Institutes of Health Office of Research Infrastructure Programs is soliciting applications for development of research models, new approach methodologies, and biological materials for studying human health and diseases, with no specified application due date in this forecast notice.

Eligible applicants include higher education institutions (public and private), 501(c)(3) and non-501(c)(3) nonprofits, state and local governments, tribal governments (federally and non-federally recognized), small businesses, for-profit organizations, faith-based and community-based organizations, regional organizations, U.S. territories, and non-domestic entities.

The program requires proposed projects to have broad applicability across multiple NIH Institutes or Centers and to explore research models or new approach methodologies spanning multiple body systems or multiple disease categories affecting multiple body systems. Applications focused on a specific disease, narrow research area, single body system, or relevance to only one NIH IC will be deemed unacceptable. Clinical trials are not allowed.

No cost share or matching requirement is stated in this forecast. Award ceilings, award floors, and expected number of awards are not specified.

Evaluation criteria assess scientific merit and significance of proposed objectives; technical adequacy of experimental design and approach; investigator or group competency; availability and adequacy of facilities and resources; budget necessity relative to project scope; and relevance to program objectives. For model development projects, reviewers will emphasize broad applicability across two or more NIH institutes and multiple organ systems.

This opportunity falls under CFDA 93.351 (Research Infrastructure Programs) within the Division of Program Coordination, Planning, and Strategic Initiatives. The broader 93.351 portfolio has obligated $6.32 billion in federal dollars across approximately 2,700 awards since 1977, with annual award volume ranging from 151 to 209 grants in recent years.

Forecast synopsis

This notice of funding opportunity (NOFO) encourages innovative research to develop, characterize, improve or preserve research models and model related biological materials, and to develop or improve technologies, including new approach methodologies (NAMs), for studies relevant to human health and diseases. This NOFO also seeks projects aimed at improving the identification and control of factors that could confound or interfere with the use of research models in biomedical research. The proposed project must have broad applicability to multiple NIH Institutes or Centers (ICs) to align with the NIH-wide mission of the Office of Research Infrastructure Programs (ORIP). The proposed studies must include research model(s) or NAM(s) and must explore multiple body systems or multiple categories of diseases affecting multiple body systems. Applications that develop models focused on a specific disease, a narrow area of research, or a single body system, or propose studies primarily relevant to a single NIH IC will be considered not acceptable to this NOFO.

Eligibility

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

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