Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional)
Open Posted
- Opportunity number
- PAR-25-024
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- City/Township Governments
- Other
- Public or Indian Housing Auth.
- 501(c)(3) Nonprofits
- Non-501(c)(3) Nonprofits
- Tribal Governments (Federally Recognized)
- Independent School Districts
- Small Businesses
- Special District Governments
- For Profit Organizations
- Higher Education Inst. (Public)
- Tribal Organizations (Not Federally Recognized)
- State Governments
- County Governments
- Higher Education Inst. (Private)
- Points of contact
-
- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health is soliciting applications for biomarker discovery and early-stage evaluation in neurological and neuromuscular disorders, with an application due date of January 7, 2028.
Eligible applicants span a broad range of entity types: higher education institutions (public and private), 501(c)(3) and non-501(c)(3) nonprofits, for-profit organizations, small businesses, state and county governments, city and township governments, tribal governments (federally recognized and not federally recognized), tribal organizations, independent school districts, special district governments, and other categories including faith-based and community-based organizations, Historically Black Colleges and Universities, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander serving institutions. Foreign organizations and non-domestic components of U.S. organizations are not eligible.
The R61/R33 mechanism funds the discovery and initial biological, analytical, and clinical evaluation of biomarkers and biomarker signatures that facilitate neurotherapeutic development. Research must include preliminary human evaluation using standardized human samples or datasets, though animal studies are permissible. The goal is to deliver candidate biomarkers ready for definitive analytical and clinical validation studies.
The funding opportunity carries CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) and CFDA 93.866 (Aging Research), administered by the National Institute of Neurological Disorders and Stroke and the National Institute on Aging. Applications are reviewed by technical panels and respective national advisory councils based on scientific merit, experimental design adequacy, investigator competency, facility adequacy, budget necessity, and relevance to program objectives. Grantees must retain financial and programmatic records for three years from annual financial status report submission.
Synopsis
The overarching purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and/or early evaluation of strong candidate biomarkers and biomarker signatures that can be used as tools to facilitate the clinical development of neurotherapeutics and their use in clinical practice. Specifically, the focus of this FOA is on the identification and initial biological, analytical and clinical evaluation of biomarkers and biomarker signatures for neurological and neuromuscular disorders. Although research supported by this FOA can include animal studies, it must also include preliminary human evaluation using carefully standardized human samples or datasets. The goal of this initiative is to deliver candidate biomarkers or biomarker signatures that are ready for definitive analytical and clinical validation studies.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-024-Full-Announcement.html | HTML file | |
| PKG00288431.pdf |
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