Cooperative Program for Modeling Clinical Transplantation
Past Federal grant forecast Posted
- Opportunity number
- RFA-AI-27-017
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Non-501(c)(3) Nonprofits
- Small Businesses
- Higher Education Inst. (Public)
- Other
- Special District Governments
- Public or Indian Housing Auth.
- Tribal Governments (Federally Recognized)
- Independent School Districts
- Tribal Organizations (Not Federally Recognized)
- State Governments
- County Governments
- Higher Education Inst. (Private)
- City/Township Governments
- For Profit Organizations
- 501(c)(3) Nonprofits
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Allergy and Infectious Diseases (NIAID) is soliciting applications for the Cooperative Program for Modeling Clinical Transplantation, a forecast opportunity supporting development of new approach methods and refined mouse models to advance solid organ transplantation therapeutics; no application deadline is specified in this forecast posting.
NIAID seeks cooperative agreements that propose innovative in-vitro and in-vivo systems modeling local and systemic immune responses relevant to transplantation. Eligible new approach methods include immune-competent microphysiological systems, organoids, ex-vivo perfused human organs, precision-cut tissue slices, and computational systems biology models. Applicants must demonstrate that proposed models overcome known obstacles to clinical translation in existing models, reduce reliance on nonhuman primates, and show relevance to clinical outcomes. Data sharing is emphasized to facilitate reproducibility and establish standards and best practices.
Eligible applicants include non-501(c)(3) and 501(c)(3) nonprofits, higher education institutions (public and private), small businesses, for-profit organizations, state and county governments, city/township governments, tribal governments (federally and non-federally recognized), tribal organizations, special district governments, public or Indian housing authorities, independent school districts, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
This opportunity is funded under the Allergy and Infectious Diseases Research program (CFDA 93.855) and is authorized by Sections 301 and 405 of the Public Health Service Act (42 USC 241 and 284) and Federal Regulations 42 CFR Part 52 and 2 CFR Part 200. Award details including ceiling, floor, expected number of awards, and period of performance are not specified in this forecast.
Forecast synopsis
The National Institute of Allergy and Infectious Diseases (NIAID) will support its mission through the Cooperative Program for Modeling Clinical Transplantation. Advancements of new therapeutics and success in human solid organ transplantation will require innovative and clinically translatable in-vitro and in-vivo systems to model local and systemic immune responses. This program seeks applications including new approach methods (NAMs) and/or refined mouse models that together will promote translation of new therapies to clinical practice. Potential NAMs include immune-competent microphysiological systems, organoids, ex-vivo perfused human organs, precision-cut tissue slices, and computational systems biology models. Applicants must propose models designed to overcome known obstacles to clinical translation in existing NAMS and/or mouse models, reduce reliance on nonhuman primates, and demonstrate relevance to clinical outcomes. Emphasis on data sharing will facilitate reproducibility and establishment of standards and best practices to achieve the program goals. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations
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