The Civil Infrastructure Systems (CIS) program, funded by the National Science Foundation (NSF), supports fundamental and innovative research in the design, operation, and management of civil infrastructure. The program focuses on civil infrastructure as an interconnected system, encouraging potentially disruptive ideas that can transform relevant research communities. Key focus areas include novel system and service design, system integration, big data analytics, and socio-technological-infrastructure connections. The program values diverse theoretical, scientific, mathematical, or computational contributions from a broad set of disciplines, but does not support research primarily focused on individual infrastructure components. Typical awards under the NSF Engineering program, which oversees the CIS opportunity, range from $250,000 to $650,000 for project periods of 3-5 years. The program is open to a wide range of applicant types, including academic institutions, research organizations, and other eligible entities across the United States.