Centers without Walls for mechanisms of neurodegeneration in Alzheimer's disease-related dementias (ADRD)
Past Federal grant forecast Posted
- Opportunity number
- RFA-NS-26-032
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Tribal Governments (Federally Recognized)
- Non-501(c)(3) Nonprofits
- State Governments
- County Governments
- Other
- Higher Education Inst. (Private)
- Public or Indian Housing Auth.
- Small Businesses
- City/Township Governments
- Independent School Districts
- For Profit Organizations
- Higher Education Inst. (Public)
- 501(c)(3) Nonprofits
- Special District Governments
- Tribal Organizations (Not Federally Recognized)
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Neurological Disorders and Stroke (NINDS) is forecasting support for research consortia investigating mechanisms of neurodegeneration in Alzheimer's disease-related dementias (ADRD) organized as "Centers without Walls," though applications are not being solicited at this time; notice is provided to allow potential applicants sufficient time to develop meaningful collaborations.
Eligible applicant types include higher education institutions (public and private), 501(c)(3) and non-501(c)(3) nonprofits, small businesses, for-profit organizations, state and county governments, city and township governments, tribal governments (federally recognized and not federally recognized), tribal organizations, independent school districts, public or Indian housing authorities, special district governments, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
The program contemplates use of an activity code such as RM1 to enable interdisciplinary research consortia. One awardee team will serve as a coordinating center to facilitate recurring meetings, data harmonization and sharing, cross-site communication, and support implementation of inter-laboratory rigor and reproducibility plans. Teams should combine multiple approaches including state-of-the-art technologies, disease-relevant models, clinical science, and human specimens to investigate disease mechanisms and identify new therapeutic targets and biomarkers. The program is informed by priorities from the ADRD Summit 2025, including embracing ADRD complexity and breaking down topic- and disease-based silos, and is intended to provide a mechanistic foundation for future translational and clinical ADRD research.
Evaluation criteria assess scientific merit and general significance, technical adequacy of experimental design, investigator competency, adequacy of facilities and resources, budget justification, and relevance to announced program objectives.
This opportunity falls under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
Forecast synopsis
The National Institute of Neurological Disorders and Stroke (NINDS) is interested in supporting ambitious research projects to elucidate mechanisms of neurodegeneration in Alzheimer's disease-related dementias (ADRD) organized as a "Center without Walls" consortium. NINDS Centers without Walls are collaborative research networks that bring together diverse expertise from different institutions to tackle complex neurological problems that are not tractable by individual research projects.
This program is considering using an activity code, such as the RM1, that enables interdisciplinary research consortia capable of identifying and characterizing novel ADRD mechanisms. Teams may include cross-disciplinary and cross-specialty expertise to address the complex co-pathologies, mixed etiologies, and disease heterogeneity in ADRD.
This program is anticipated to support teams that can combine multiple approaches, such as state-of-the-art technologies, disease-relevant models, clinical science, and human specimens, to investigate unique disease mechanisms and identify new therapeutic targets, biomarkers, and other factors influencing ADRD susceptibility, resilience, and pathology. One awardee team would serve as a coordinating center for all awardees to facilitate recurring meetings, data harmonization and sharing, cross-site communication, and support the implementation of inter-laboratory rigor and reproducibility plans.
This program is informed by key priorities from the ADRD Summit 2025, including embracing ADRD complexity and breaking down topic- and disease-based silos, and is intended to provide a mechanistic foundation for future translational and clinical ADRD research.
Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with complementary expertise in ADRD mechanisms, clinical phenotypes, and advanced technologies are encouraged to contact agency staff listed below for additional information.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;
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