Cancer Intervention and Surveillance Modeling Network (CISNET) (U01 Clinical Trial Not Allowed)

Closed Posted

Opportunity number
RFA-CA-25-032
Agency
Applications due
Award size
Up to $1,240,000

Opportunity facts

Assistance listings
Funding instrument
Cooperative Agreement
Category
  • Health
Eligible applicants
  • Other
  • Tribal Governments (Federally Recognized)
  • Higher Education Inst. (Private)
  • Small Businesses
  • City/Township Governments
  • 501(c)(3) Nonprofits
  • Higher Education Inst. (Public)
  • Non-501(c)(3) Nonprofits
  • County Governments
  • Independent School Districts
  • State Governments
  • Public or Indian Housing Auth.
  • Tribal Organizations (Not Federally Recognized)
  • Special District Governments
  • For Profit Organizations
Points of contact

Opportunity details come from Grants.gov. Updated .

About this opportunity

The National Institutes of Health (NIH) is seeking collaborative research applications for the Cancer Intervention and Surveillance Modeling Network (CISNET), focusing on developing sophisticated simulation and modeling techniques for specific cancer types including bladder, breast, cervical, colon/rectum, esophagus, gastric, multiple myeloma, lung, prostate, and uterine cancers. The primary objective is to generate evidence-based tools that can inform decisions about cancer control strategies, with the ultimate goal of reducing cancer risk, incidence, morbidity, and mortality. Applicants must use a comparative modeling approach involving 2-6 independent modeling teams and one coordinating center, demonstrating technical adequacy of experimental design, investigator competency, and relevance to program objectives. The evaluation criteria will assess scientific merit, experimental approach, investigator qualifications, available resources, budget necessity, and alignment with program goals. The electronic submission deadline through Grants.gov is January 11, 2026, with an earliest potential start date of February 11, 2026.

The NIH intends to commit $9.438 million in fiscal year 2026 to fund up to eight awards, with individual awards requesting budgets up to $1.24 million in direct costs per year for a maximum five-year project period. Eligible applicants include higher education institutions, nonprofits, for-profit organizations, state and local governments, and federal agencies, with both domestic and foreign organizations permitted to apply. The project will be conducted through a cooperative agreement mechanism under the Cancer Control Federal Grant Program (CFDA 93.399), with research teams expected to collaborate and develop comprehensive modeling tools that can extend evidence from existing trials and epidemiological studies.

Synopsis

The purpose of this Notice of Funding Opportunity (NOFO) is to request applications for the Cancer Intervention and Surveillance Modeling Network (CISNET) (https://cisnet.cancer.gov). This NOFO invites multiple PD/PI applications for collaborative research projects using simulation and other modeling techniques for specific cancer types (see below). The proposed research is expected to generate sophisticated, evidence-based tools capable of informing decisions on the most efficient utilization of existing and emerging technologies and strategies for the control of cancer.

Files

File Type Posted
RFA-CA-25-032-Full-Announcement.html HTML file

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