BRAIN Initiative: Development and Validation of Novel Tools and New Approaches for Neuroscience Research
Forecasted Federal grant Posted
- Opportunity number
- RFA-MH-28-110
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Not on record
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Tribal Organizations (Not Federally Recognized)
- City/Township Governments
- Non-501(c)(3) Nonprofits
- Tribal Governments (Federally Recognized)
- Other
- State Governments
- County Governments
- 501(c)(3) Nonprofits
- Small Businesses
- Higher Education Inst. (Private)
- Special District Governments
- Independent School Districts
- Public or Indian Housing Auth.
- For Profit Organizations
- Higher Education Inst. (Public)
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health is forecasting a Notice of Funding Opportunity to solicit applications for research developing novel tools and approaches that enable interrogation of cell-specific and circuit-specific processes in the central nervous system, consolidating three current BRAIN Initiative tool development programs with no hard deadline specified in this forecast.
Eligible applicants include higher education institutions (public and private), 501(c)(3) nonprofits, small businesses, state and county governments, tribal governments (federally recognized and unrecognized), city/township governments, special district governments, independent school districts, for-profit organizations, non-501(c)(3) nonprofits, public or Indian housing authorities, eligible federal agencies, U.S. territories or possessions, faith-based or community-based organizations, regional organizations, and non-domestic entities.
The program encourages projects across broad stages of development, from early-stage conceptualization through optimization of existing instrumentation. Targeted research areas include novel tools to characterize cell-types, circuits, and cellular components with greater selectivity and sensitivity using new genetic or non-genetic delivery technologies, genetic sensors or tracers for imaging or monitoring molecules and structures within cells and circuits with significant advances in sensitivity, selectivity, or spatiotemporal resolution, and new technologies for recording and modulation of neural cells and circuits using optical, electrical, magnetic, or acoustic modalities to target neuronal electrical signals and other forms of neural activity, including intracellular signaling and engagement of non-neuronal cells.
The opportunity operates under CFDA 93.242 (Mental Health Research Grants) administered by the National Institute of Mental Health. Award mechanisms and amounts are not specified in this forecast. Applications will be evaluated through peer review for scientific and technical merit, program relevance, and program balance, with consideration of availability of funds.
Forecast synopsis
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research to develop novel tools and approaches that enable the interrogation of cell-specific and circuit-specific processes in the central nervous system. This NOFO consolidates three current BRAIN Initiative tool development programs.
Projects that focus on developing a broad range of new research tools to delineate anatomical and functional connections between cells and circuits, and to expand our knowledge of brain architecture and function are encouraged, such as projects that:
- Develop novel tools to characterize/define cell-types, circuits, and cellular components in the nervous system with greater selectivity and sensitivity, including:
- new genetic or non-genetic technologies/approaches (for delivering genes, proteins, and chemicals to access and/or manipulate cells of interest)
- novel sensors or tracers for imaging or monitoring molecules, structures, and activities within single cells and circuits with significant advances in sensitivity, selectivity, or spatiotemporal resolution
- Develop new technologies and novel approaches for recording and modulation of neural cells and circuits, including:
- approaches to address major challenges and enable transformative understanding of dynamic signaling in the central nervous system
- approaches that utilize any modality, such as optical, electrical, magnetic, or acoustic recording/manipulation
- approaches to target neuronal electrical signals or other forms of neural activity, including intracellular signaling and engagement of non-neuronal cells in circuit function.
Projects at broad stages of development are supported, from unique and innovative technologies that are in the earliest stage of development (including new and untested ideas that are in the initial stages of conceptualization) through the optimization of existing instrumentation with transformative potential in order to facilitate broad adoption. Applications that offer transformative approaches that break through existing technical barriers and substantially improve current capabilities are strongly encouraged. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RP1 activity code.
Eligibility
Other Eligible ApplicantsEligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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