Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)
Open Posted
- Opportunity number
- PAR-26-040
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Up to $250,000
Opportunity facts
- Assistance listings
-
- 93.879 Medical Library Assistance
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Tribal Organizations (Not Federally Recognized)
- 501(c)(3) Nonprofits
- Public or Indian Housing Auth.
- Other
- City/Township Governments
- Independent School Districts
- For Profit Organizations
- County Governments
- Higher Education Inst. (Public)
- Tribal Governments (Federally Recognized)
- Higher Education Inst. (Private)
- Special District Governments
- Small Businesses
- State Governments
- Non-501(c)(3) Nonprofits
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Library of Medicine seeks applications for research in bioinformatics, translational bioinformatics, and computational biology, with applications due March 5, 2029 (rolling quarterly deadlines begin April 6, 2026).
Eligible applicants include higher education institutions (public and private), nonprofits (501(c)(3) and non-501(c)(3)), for-profit organizations, state and local governments, tribal governments (federally and non-federally recognized), and foreign organizations. However, foreign subawards and subcontracts are prohibited; unfunded international collaborations and foreign consultants are permitted. Applicants must register in the System for Award Management, eRA Commons, and Grants.gov.
Awards cap at $250,000 per year in direct costs with a maximum project period of four years. The program uses the R01 activity code under Assistance Listing 93.879 (Medical Library Assistance).
The initiative prioritizes groundbreaking innovation leveraging artificial intelligence, machine learning, and large-scale computational platforms to extract actionable knowledge from complex biological datasets. Eligible research spans omics-based bioinformatics, microbiome research, genetic variation analysis, systems biology, single-cell informatics, and biomarker discovery at molecular, cellular, tissue, organismal, and population levels. The program encourages interdisciplinary collaboration and scalable, autonomous innovations with potential for impact across biomedical and clinical domains.
Applicants must develop comprehensive Data Management and Sharing Plans and Resource Sharing Plans with detailed software dissemination strategies. Non-responsive projects include those with incremental improvements to existing tools, narrow disease focus, minimal open-access outputs, or heavy experimental components. Evaluation criteria emphasize significance and innovation, rigorous methodology with benchmarking and validation metrics, and investigator expertise and institutional resources. Scientific merit review occurs approximately five months after deadlines, with advisory council review and earliest start dates following.
Synopsis
The National Library of Medicine (NLM) seeks applications for research projects that drive groundbreaking innovation and advanced development in the fields of bioinformatics, translational bioinformatics, and computational biology. The primary goal of this initiative is to support the creation and implementation of cutting-edge methods, tools, and approaches that can transform the landscape of biomedical data science. This NOFO aims to address the growing need to leverage transformative technologies - such as artificial intelligence (AI), machine learning, and large-scale computational platforms - to extract actionable knowledge from vast, diverse, and complex biological datasets. By enabling more effective interpretation and integration of multi-dimensional biological and biomedical data, this research will ultimately contribute to improving individual and population health outcomes.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Files
| File | Type | Posted |
|---|---|---|
| PKG00291955.pdf | ||
| PAR-26-040-Full-Announcement.html | HTML file |
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