Advanced Integrated Research Technologies and Support Services for Biological Studies OTSS Contract Blanket Order

Past New Requirement Updated

Agency
Solicitation expected
Estimated value
$13,000,000 to $20,000,000
Set-aside
Total Small Business

Forecast facts

Anticipated award
NAICS code
541990 All Other Professional, Scientific, and Technical Services
Points of contact

Forecast details come from HHS's procurement forecast. Agencies' dates and values are estimates.

About this forecast

Written by GovTribe AI ·

The National Institutes of Health, through the National Institute of Allergy and Infectious Diseases (NIAID) and other NIH Institutes and Centers, plans to procure advanced technical support for intramural research programs, including high-containment laboratories, under the Advanced Integrated Research Technologies and Support Services for Biological Studies OTSS Contract Blanket Order, with an estimated solicitation release date of 2026-08-01 and an estimated award date of 2026-09-01. The contractor must supply specialized scientific expertise and highly trained professionals across seven areas: genomics (next-generation and single-cell sequencing, spatial genomics, TaqMan RT-qPCR), protein chemistry (mass spectrometry proteomics and metabolomics, Edman N-terminal sequencing, bioinformatics tool development), microscopy (cryoEM, CLEM, TEM, SEM, digital spatial profiling), flow cytometry at RG2 through RG4 (single-cell sorting, spectral and imaging cytometry, custom antibody production), structural biology (X-ray crystallography, ITC, biolayer interferometry), Center for Human Immunology multiomics (CITE-seq, ATAC-seq, TCR/BCR sequencing, 40-color spectral cytometry, SomaScan proteomics covering 11,000 proteins), and program management and administration.

The estimated award value range is $13.0 million to $20.0 million under a Total Small Business set-aside, classified under NAICS 541990, All Other Professional, Scientific, and Technical Services. Point of contact is Matthew Lear, Contracting Officer, at matt.lear@nih.gov or +12406695109, with James Cherry as a secondary contact at jim.cherry@nih.gov.

Forecast text

The National Institute of Allergy and Infectious Diseases (NIAID), and other NIH Institutes and Centers (ICs) require advanced technical support in the following scientific and administrative disciplines. The Contractor shall provide specialized scientific expertise to integrate advanced technologies into NIH intramural research programs, including high containment laboratories, using highly trained scientific professionals and support staff.

3.1 Genomics Research Section (GRS)

Requires nextgeneration DNA/RNA sequencing, singlecell RNA processing, spatial genomics, longread DNA sequencing, and highthroughput TaqMan (RTqPCR) gene expression analysis.

3.2 Protein Chemistry Section (PCS)

Requires highresolution analytical mass spectrometry for proteomics/metabolomics, protein identification from complex samples, advanced protein separation, custom assay development, comprehensive proteomic services, Edman Nterminal sequencing, microbial identification via MS, analysis of protein kinetics/interactions, characterization of biomolecular assemblies, and bioinformatics tool development.

3.3 Microscopy Unit

Requires 3D tomography/TEM reconstruction, advanced confocal imaging, light microscopy, digital spatial profiling, CLEM, cryoEM, immunoelectron microscopy, SEM for surface structure, and TEM for internal structure.

3.4 Flow Cytometry Section

Requires advanced cell analysis/sorting at RG2-RG4, precise singlecell sorting/cloning, ultradeep immunophenotyping (>30 parameters), spectral cytometry, imaging cytometry, custom antibody production/validation, and monthly consultation and training workshops.

3.5 Structural Biology Section (SBS)

Requires advisory services for highquality protein sample preparation; protein production; sample optimization for Xray and cryoEM; aggregation analysis via light scattering; affinity measurements via ITC and biolayer interferometry; Xray crystallography; and monthly training in biochemical/biophysical methods.

3.6 Center for Human Immunology (CHI)

Requires singlecell and bulk genomics (CITEseq, ATACseq, scRNAseq, TCR/BCR sequencing), 40color spectral cytometry, CyTOF phosphoanalysis, flow sorting for enriched populations, proteomics via SomaScan (11,000 proteins), bioinformatics for NGS, cytometry, SomaScan, transcriptomics, epigenetics, genomics, functional analyses, and development of largescale multiomics pipelines.

3.7 Program Management/Administration

Requires administrative and project management support, including contract and budget management, procurement, operating procedures, delegation workflows, meeting organization, scheduling, reporting, evaluation of ongoing programs, and assistance with budgeting and cost control.

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