Substances for Pharmacology Testing

The Drug Enforcement Administration (DEA) is seeking a contractor to custom synthesize 14 specific chemical substances for pharmacological testing and abuse potential evaluation. This solicitation is focused on supporting the DEA's Office of Diversion Control Operations, Chemical Control Unit in gathering scientific data to determine regulatory control potential under the Controlled Substances Act. The substances to be synthesized include complex chemical compounds such as ortho methylfentanyl, Fluetonitazene, N-pyrrolidino fluetonitazene, and other related chemicals. Most substances are required in 1g quantities, with 2-bromo Deschloroketamine specified at 500mg. The solicitation is posted on March 18, 2025, with proposals due by April 2, 2025, and is categorized under NAICS code 325199 for All Other Basic Organic Chemical Manufacturing.

The contract opportunity is set aside for total small business participation and will be performed in West Springfield, VA. While specific award value is not explicitly stated, the procurement involves precise scientific substance synthesis for critical regulatory research. Contractors must comply with extensive security provisions outlined in the DEA Provision and Clause Matrix, including personnel security requirements and cybersecurity safeguards. The procurement falls under Product Service Code (PSC) 6505 for Drugs and Biologicals, indicating a specialized scientific procurement. Potential contractors will need to demonstrate significant technical capability in organic chemical synthesis, particularly for controlled substance analogs, and must be prepared to undergo rigorous background investigations and security protocols typical of Department of Justice contracts.