Rapid Assessment Machine Learning Software License

The Food and Drug Administration (FDA) is soliciting quotations for eight ADMET Predictor software license renewals to support the Center for Tobacco Products' toxicology review operations. The solicitation seeks brand name or equal software licenses across multiple modules including Physicochemical and Biopharmaceutical, MedChem Designer, Chemistry, Toxicity, Metabolism, HTPK Simulation, ADMET Modeler, and MedChem Studio modules. The software must predict 140 chemical properties relevant to tobacco product ingredients and support functions such as structure-activity relationship analysis, custom model creation, metabolism prediction by multiple CYP isoforms, and toxicity predictions. The government will evaluate quotations using a Lowest Price Technically Acceptable (LPTA) criterion, awarding to the responsible quoter offering the lowest compliant price. Key deadlines include a question submission deadline of February 12, 2026 at 10:00 AM Eastern Time and a quotation closing date of February 17, 2026 at 3:00 PM Eastern Time, with inquiries directed to Robert Waite and Narissa Charles at the FDA.

This procurement includes no set-aside designations and will be awarded as a firm-fixed-price contract with a base period from February 20, 2026 to February 19, 2027, followed by four optional one-year renewal periods extending through February 19, 2031. The contractor must provide software updates, maintenance, ongoing training, and comprehensive technical support via telephone, web-based platforms, and email throughout the license term. Payment terms are Net 30 days after government acceptance with no advance payments permitted. The solicitation incorporates stringent requirements including FIPS 140-2 encryption, Tier 2 sensitivity level background investigations for personnel, and compliance with HHS/FDA security policies and information technology standards. Performance of services will be conducted in Silver Spring, Maryland, and the contract falls under NAICS Code 513210 (Software Publishers) and PSC 7A21 (Business Application Software—Perpetual License).