Purchase U-13C glucose for human study
Closed Pre-Solicitation Posted
A newer solicitation was posted. See the latest solicitation from .
- Solicitation number
- NIMH24003242
- Agency
- Office of the Assistant Secretary for Preparedness and Response Department of Health and Human Services
- Responses due
- Set-aside
- Total Small Business
Opportunity facts
- NAICS code
- 325199 All Other Basic Organic Chemical Manufacturing
- Place of performance
- Andover, Massachusetts 01810, United States
Notice details come from SAM.gov. Updated .
About this opportunity
The Department of Health and Human Services Office of the Assistant Secretary for Preparedness and Response is seeking to procure [U-13C6] glucose, a stable isotope used in metabolic research projects. The glucose will be used to prepare 20% solutions for oral administration to human subjects during magnetic resonance spectroscopy (MRS) studies examining brain metabolism. The government has specified technical requirements for the product, including purity, packaging, and quantity. Responses must provide information on the company's ability to meet these requirements, as well as its small business status. The government is particularly interested in identifying qualified small business sources and will provide evaluation preferences for domestic sources in any future solicitation.
This procurement is set aside for small businesses under the specified NAICS code (325199 - All Other Basic Organic Chemical Manufacturing). The anticipated period of performance is 12 months. While no incumbent contractors are named, the government expects to use approximately 40-50 grams of [U-13C6] glucose per human study, with multiple studies planned. The pre-solicitation notice does not provide any details on the anticipated award value or budgetary constraints.
Notice text
Stable isotopes have been used safely in clinical research for decades and have contributed seminal insights into human metabolism. Magnetic Resonance Spectroscopy (MRS) Section and Core have been conducting research projects using carbon-13 (13C) labeled glucose to study brain metabolism of healthy volunteers for more than ten years.
MRS detects nuclear magnetic resonance signals from nuclei in human tissue. Common MRS detect signals from protons which are dominant nuclei in living tissues. 13C MRS detect signals from carbons instead of protons, which can provide different information of metabolism.
Because natural abundance of 13C is only one percent, signals from natural 13C is too weak to be detected. Thus, we need to administrate 13C enriched chemicals into human subjects to increase 13C signal intensity.
In an ongoing project, [U-13C6] glucose will be used. The glucose will be prepared into 20% solution for oral administration. Each human study will use 40-50 grams of [U-13C6] glucose depending on the body weight of the subject. With the administration of 13C labeled glucose, we should be able to measure 13C signals in a reasonable period of time.
Attachments
| File | Type | Posted |
|---|---|---|
| Sources Sought Notice.docx | DOCX document |
Notice history
| Notice | Type | Posted |
|---|---|---|
| D-glucose (u-13C6, 99%), microbiological/pyrogen tested | Solicitation | |
| Purchase U-13C glucose for human study | Pre-Solicitation |
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