Procurement of a Brand Name or Equal Intelligent Imaging Innovation Lattice LightSheet System: 4 color and two camera with Analysis workstation

Contracting Office Address
Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions (OA), 9609 Medical Center Drive, Room 1E136, Bethesda, MD 20892, UNITED STATES.

Non-USPS mail such as Fedex, UPS and other private carriers please use Rockville, MD 20850.

The National Cancer Institute (NCI), Center for Cancer Research (CCR), Laboratory of Receptor Biology and Gene Expression (LRBGE), Optical Microscopy Core (OMC) plans to procure a Brand Name or Equal Intelligent Imaging Innovation Lattice LightSheet System: 4 color with two cameras and an analysis workstation.

This is a combined synopsis/solicitation for commercial items, prepared in accordance with format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation: No. 75N91019Q00057 includes all applicable provisions and clauses in effect through FAR FAC 2019-03 (June 2019) simplified procedures for commercial items.

The North American Industry Classification System code is 334516 and the business size standard is 500 employees.

Only one award will be made as a result of this solicitation. This will be awarded as a Severable Firm Fixed Price type contract.

BACKGROUND

The National Cancer Institute (NCI), Center for Cancer Research (CCR), Laboratory of Receptor Biology and Gene Expression (LRBGE) Optical Microscopy Core (OMC) requires the purchase of a Brand Name or Equal Lattice Light Sheet (LLS) Imaging System. This is a unique state-of the art system providing unprecedented spatiotemporal resolution for a long-term 3D non-photodamage non-photobleaching imaging. This translates into a quantitative and qualitative increase in information. Lattice Light Sheet state of the art technology surpasses the traditional techniques of live imaging such as laser scanning and spinning disc confocal technology as well as the other technologies of light sheet imaging. The LLS technique is widely applicable to the wide range of specimens from molecules to tissues and it will benefit numerous studies of cancer malignancy at CCR and NCI. Purchase of this system will be indispensable to the mission of NIH.

PRODUCT FEATURES/SALIENT CHARACTERISTICS

The following product features and salient characteristics apply to this acquisition:

· Optical Lattice Light Sheet Illumination Technique Based on Annular Mask Generating Parallel Arrays of narrow bessel light beams with adjustable light sheet thickness that can be scanned through the sample at high speeds reducing photodamage and photobleaching;

· Light Sheet Thickness, adjustable light sheet thickness and length with a minimum thickness of 0.4μm at 50μm length;

· Dither-mode LLS Resolution with improved Z: 230 x 230 x 370nm @ 1.1 NA;

· Super Resolution Lattice Structured Illumination (SIM): 150 x 230 x 280nm @ 1.1 NA;

· Detection Optics: water dipping objective, 2.0mm WD, 62.5x total magnification, which can be used without any material between the sample and objective;

· Illumination Optics: custom-made water dipping objective, 3.7mm WD, which can be used without any material between the sample and objective;

· Transmitted Light Imaging: LED light source and dedicated camera for location of cells;

· High Power Lasers, (> 300 mW): 405 350mW, 488 500mW, 560 500mW, 642 500mW;

· Two (2) Camera for Two-Channel Simultaneous Imaging: Hamamatsu ORCA-FUSION sCMOS camera with 80% QE and quiet scan 0.7e read noise, cooled to -5C, 2304x2304 pixels. The larger size of the detector on the ORCA-FUSION also results in a larger field-of-view. The reduced read noise compared to other cameras, such as the ORCA-FLASH 4.0 V3, is crucial for imaging samples with low numbers of photons. Alternative camera would be Photometrics Prime BSI, which has a read noise of 1.0 e.

· Chamber: Temperature and CO2 control with perfusion capabilities

· Specimen Mounting: Standard, non-proprietary chambers or slides, such as horizontally-oriented 5mm round glass coverslips which could also be imaged on other microscopes.

· Computer with Dual 10-Core, 2.4GHz processors, 128GB RAM, 8GB graphics card, 1TB OS SSD and 6TB SSD array, 10GbE (copper) Adapter

· Additional Processing Workstation with the Analysis Computer; Dual 10-Core, 2.4GHz processors, 128GB RAM, 8GB graphics card, 1TB OS SSD and 6TB SSD array, 10GbE (copper) Adapter

· Storage Solutions with DDN® unified storage systems for direct full-speed acquisition and analysis for the terabyte-size images, with a minimal storage size of 300TB. DDN systems utilize a BioScaler GPFS file system and are easily expandable to multiple petabytes.

· Lattice Tune-Up Capacities: Cameras in image and Fourier space to inspect the lattice and annular mask for tune up.

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• Image Processing and Display: GPU accelerated deconvolution that can work from either a measured or theoretical PSF. 3D visualization software that can import multi-terabyte datasets and display them in a few seconds.
  

· Open design allowing modifications for the future incorporation of adaptive optics.

· All shipping, delivery and installation costs must be included in the quote. NCI will not be responsible after award is made, if shipping costs are not included.Contracting Office Address
Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions (OA), 9609 Medical Center Drive, Room 1E136, Bethesda, MD 20892, UNITED STATES.

Non-USPS mail such as Fedex, UPS and other private carriers please use Rockville, MD 20850.

The National Cancer Institute (NCI), Center for Cancer Research (CCR), Laboratory of Receptor Biology and Gene Expression (LRBGE), Optical Microscopy Core (OMC) plans to procure a Brand Name or Equal Intelligent Imaging Innovation Lattice LightSheet System: 4 color with two cameras and an analysis workstation.

This is a combined synopsis/solicitation for commercial items, prepared in accordance with format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation: No. 75N91019Q00057 includes all applicable provisions and clauses in effect through FAR FAC 2019-03 (June 2019) simplified procedures for commercial items.

The North American Industry Classification System code is 334516 and the business size standard is 500 employees.

Only one award will be made as a result of this solicitation. This will be awarded as a Severable Firm Fixed Price type contract.

BACKGROUND

The National Cancer Institute (NCI), Center for Cancer Research (CCR), Laboratory of Receptor Biology and Gene Expression (LRBGE) Optical Microscopy Core (OMC) requires the purchase of a Brand Name or Equal Lattice Light Sheet (LLS) Imaging System. This is a unique state-of the art system providing unprecedented spatiotemporal resolution for a long-term 3D non-photodamage non-photobleaching imaging. This translates into a quantitative and qualitative increase in information. Lattice Light Sheet state of the art technology surpasses the traditional techniques of live imaging such as laser scanning and spinning disc confocal technology as well as the other technologies of light sheet imaging. The LLS technique is widely applicable to the wide range of specimens from molecules to tissues and it will benefit numerous studies of cancer malignancy at CCR and NCI. Purchase of this system will be indispensable to the mission of NIH.

PRODUCT FEATURES/SALIENT CHARACTERISTICS

The following product features and salient characteristics apply to this acquisition:

• Optical Lattice Light Sheet Illumination Technique Based on Annular Mask Generating Parallel Arrays of narrow bessel light beams with adjustable light sheet thickness that can be scanned through the sample at high speeds reducing photodamage and photobleaching;
• Light Sheet Thickness, adjustable light sheet thickness and length with a minimum thickness of 0.4μm at 50μm length;
• Dither-mode LLS Resolution with improved Z: 230 x 230 x 370nm @ 1.1 NA;
• Super Resolution Lattice Structured Illumination (SIM): 150 x 230 x 280nm @ 1.1 NA;
• Detection Optics: water dipping objective, 2.0mm WD, 62.5x total magnification, which can be used without any material between the sample and objective;
• Illumination Optics: custom-made water dipping objective, 3.7mm WD, which can be used without any material between the sample and objective;
• Transmitted Light Imaging: LED light source and dedicated camera for location of cells;
• High Power Lasers, (> 300 mW): 405 350mW, 488 500mW, 560 500mW, 642 500mW;
• Two (2) Camera for Two-Channel Simultaneous Imaging: Hamamatsu ORCA-FUSION sCMOS camera with 80% QE and quiet scan 0.7e read noise, cooled to -5C, 2304x2304 pixels. The larger size of the detector on the ORCA-FUSION also results in a larger field-of-view. The reduced read noise compared to other cameras, such as the ORCA-FLASH 4.0 V3, is crucial for imaging samples with low numbers of photons. Alternative camera would be Photometrics Prime BSI, which has a read noise of 1.0 e.
• Chamber: Temperature and CO2 control with perfusion capabilities
• Specimen Mounting: Standard, non-proprietary chambers or slides, such as horizontally-oriented 5mm round glass coverslips which could also be imaged on other microscopes.
• Computer with Dual 10-Core, 2.4GHz processors, 128GB RAM, 8GB graphics card, 1TB OS SSD and 6TB SSD array, 10GbE (copper) Adapter
• Additional Processing Workstation with the Analysis Computer; Dual 10-Core, 2.4GHz processors, 128GB RAM, 8GB graphics card, 1TB OS SSD and 6TB SSD array, 10GbE (copper) Adapter
• Storage Solutions with DDN® unified storage systems for direct full-speed acquisition and analysis for the terabyte-size images, with a minimal storage size of 300TB. DDN systems utilize a BioScaler GPFS file system and are easily expandable to multiple petabytes.
• Lattice Tune-Up Capacities: Cameras in image and Fourier space to inspect the lattice and annular mask for tune up.
• Image Processing and Display: GPU accelerated deconvolution that can work from either a measured or theoretical PSF. 3D visualization software that can import multi-terabyte datasets and display them in a few seconds.
• Open design allowing modifications for the future incorporation of adaptive optics.
• All shipping, delivery and installation costs must be included in the quote. NCI will not be responsible after award is made, if shipping costs are not included.
• Coordination of delivery and installation with the NCI Technical Point of Contact.

DELIVERY / INSTALLATION

The delivery address is:
NCI/NIH, LRBGE Optical Microscopy Core
Bldg. 41, Rm. C615
41 Medlars Drive
Bethesda, MD 20892

Delivery timeframe: The item shall be delivered within 12-16 weeks after the purchase order is awarded.

TRAINING

Four-day training will be provided within one week after installation of the equipment for three (3) OMC staff members in Bethesda, MD.

PAYMENT

Payment shall be made after delivery and acceptance of the NCI COR. Payment authorization requires submission and approval of invoice to the NCI COR and NIH Commercial Accounts.

BASIS OF AWARD

The purchase order will be awarded to the Lowest Price Technically Acceptable (LPTA). The award will be made on the basis of the lowest evaluated price of quotations meeting or exceeding the acceptability standards for the requirements/technical specifications stated above. The technical evaluation will be a determination based on information furnished by the vendor. The Government is not responsible for locating or securing any information which is not identified in the quote. The Government reserves the right to make an award without discussions.

PROVISIONS AND CLAUSES

FAR 52.211-6 Brand Name or Equal. (Aug 1999).
(a) If an item in this solicitation is identified as "brand name or equal," the purchase description reflects the characteristics and level of quality that will satisfy the Government's needs. The salient physical, functional, or performance characteristics that "equal" products must meet are specified in the solicitation

(b) (b) To be considered for award, offers of "equal" products, including "equal" products of the brand name manufacturer, must-

(1) Meet the salient physical, functional, or performance characteristic specified in this solicitation;

(2) Clearly identify the item by-

(i) Brand name, if any; and

(ii) Make or model number;

(3) Include descriptive literature such as illustrations, drawings, or a clear reference to previously furnished descriptive data or information available to the Contracting Officer; and

(4) Clearly describe any modifications the offeror plans to make in a product to make it conform to the solicitation requirements. Mark any descriptive material to clearly show the modifications

(c) The Contracting Officer will evaluate "equal" products on the basis of information furnished by the offeror or identified in the offer and reasonably available to the Contracting Officer. The Contracting Officer is not responsible for locating or obtaining any information not identified in the offer

(d) Unless the offeror clearly indicates in its offer that the product being offered is an "equal" product, the offeror shall provide the brand name product referenced in the solicitation.

Offerors providing an "equal" product must submit additional documentation that highlights and describes how the offer is equal in accordance with FAR Clause 52.211-6.

52.212-1 Instructions to Offerors Commercial Items (Oct 2018);

52.212-2 Evaluation Commercial Items (Oct 2014):

52.212-3 Offeror Representations and Certifications - Commercial Items (Oct 2018)

52.212-4 Contract Terms and Conditions - Commercial Items (Oct 2018)

52.212-5: Contract Terms and Conditions Required to Implement Statues or Executive Orders - Commercial Items (Oct 2018). The following FAR clauses:

52.203-6, Restrictions on Subcontractor Sales to the Government (Sept 2006), with Alternate I (Oct 1995)

52.204-10, Reporting Executive Compensation and First-Tier Subcontract Awards (Oct 2018)

52.209-6, Protecting the Government's Interest When Subcontracting with Contractors Debarred, Suspended, or Proposed for Debarment. (Oct 2015)

52.219-4, Notice of Price Evaluation Preference for HUBZone Small Business Concerns (OCT 2014)

52.219-6, Notice of Total Small Business Set-Aside (Nov 2011)

52.219-8, Utilization of Small Business Concerns (Oct 2018)

52.219-13, Notice of Set-Aside of Orders (Nov 2011)

52.219-14, Limitations on Subcontracting (Jan 2017)

52.219-28, Post Award Small Business Program Representation (Jul 2013)

52.222-3, Convict Labor (June 2003)

52.222-19, Child Labor-Cooperation with Authorities and Remedies (Jan 2018)

52.222-21, Prohibition of Segregated Facilities (Apr 2015)

52.222-26, Equal Opportunity (Sept 2016)

52.222-35, Equal Opportunity for Veterans (Oct 2015)

52.222-36, Equal Opportunity for Workers with Disabilities (July 2014)

52.222-37, Employment Reports on Veterans (Feb 2016)

52.222-40, Notification of Employee Rights Under the National Labor Relations Act (Dec 2010)

52.222-50, Combating Trafficking in Persons (Jan 2019)

52.222-54, Employment Eligibility Verification (OCT 2015)

52.223-18, Encouraging Contractor Policies to Ban Text Messaging While Driving (AUG 2011)

52.225-1, Buy American-Supplies (May 2014)

52.225-13, Restrictions on Certain Foreign Purchases (June 2008)

52.232-33, Payment by Electronic Funds Transfer-System for Award Management (Oct 2018)

Full text copies of the representations and certifications for other cited provisions and clauses may be obtained on line at the NCI website at http://ncioa.cancer.gov/oa-internet/

OFFERORS: Offers must be submitted with a completed 52.212-3 Offeror Representations and Certifications-Commercial Items-with DUNS Number Addendum, signed by an authorized representative of the offeror OR provide a copy of the valid SAM registration through www.sam.gov.

Quotations must be received in the NCI OA contracting office by 5:00 p.m. EST on July 17, 2019. Please refer to solicitation number 75N91019Q00057 on all correspondence. Faxed quotations will NOT be accepted. Quotations may be submitted via email to Kimesha Leake, Contracting Officer at Kimesha.leake@nih.gov . No collect calls will be accepted. In order to receive an award, Contractors must be registered and have valid certification in the System for Award Management through sam.gov.

· Coordination of delivery and installation with the NCI Technical Point of Contact.

DELIVERY / INSTALLATION

The delivery address is:
NCI/NIH, LRBGE Optical Microscopy Core
Bldg. 41, Rm. C615
41 Medlars Drive
Bethesda, MD 20892

Delivery timeframe: The item shall be delivered within 12-16 weeks after the purchase order is awarded.

TRAINING

Four-day training will be provided within one week after installation of the equipment for three (3) OMC staff members in Bethesda, MD.

PAYMENT

Payment shall be made after delivery and acceptance of the NCI COR. Payment authorization requires submission and approval of invoice to the NCI COR and NIH Commercial Accounts.

BASIS OF AWARD

The purchase order will be awarded to the Lowest Price Technically Acceptable (LPTA). The award will be made on the basis of the lowest evaluated price of quotations meeting or exceeding the acceptability standards for the requirements/technical specifications stated above. The technical evaluation will be a determination based on information furnished by the vendor. The Government is not responsible for locating or securing any information which is not identified in the quote. The Government reserves the right to make an award without discussions.

PROVISIONS AND CLAUSES

FAR 52.211-6 Brand Name or Equal. (Aug 1999).
(a) If an item in this solicitation is identified as "brand name or equal," the purchase description reflects the characteristics and level of quality that will satisfy the Government's needs. The salient physical, functional, or performance characteristics that "equal" products must meet are specified in the solicitation

(b) (b) To be considered for award, offers of "equal" products, including "equal" products of the brand name manufacturer, must-

(1) Meet the salient physical, functional, or performance characteristic specified in this solicitation;

(2) Clearly identify the item by-

(i) Brand name, if any; and

(ii) Make or model number;

(3) Include descriptive literature such as illustrations, drawings, or a clear reference to previously furnished descriptive data or information available to the Contracting Officer; and

(4) Clearly describe any modifications the offeror plans to make in a product to make it conform to the solicitation requirements. Mark any descriptive material to clearly show the modifications

(c) The Contracting Officer will evaluate "equal" products on the basis of information furnished by the offeror or identified in the offer and reasonably available to the Contracting Officer. The Contracting Officer is not responsible for locating or obtaining any information not identified in the offer

(d) Unless the offeror clearly indicates in its offer that the product being offered is an "equal" product, the offeror shall provide the brand name product referenced in the solicitation.

Offerors providing an "equal" product must submit additional documentation that highlights and describes how the offer is equal in accordance with FAR Clause 52.211-6.

52.212-1 Instructions to Offerors Commercial Items (Oct 2018);

52.212-2 Evaluation Commercial Items (Oct 2014):

52.212-3 Offeror Representations and Certifications - Commercial Items (Oct 2018)

52.212-4 Contract Terms and Conditions - Commercial Items (Oct 2018)

52.212-5: Contract Terms and Conditions Required to Implement Statues or Executive Orders - Commercial Items (Oct 2018). The following FAR clauses:

52.203-6, Restrictions on Subcontractor Sales to the Government (Sept 2006), with Alternate I (Oct 1995)

52.204-10, Reporting Executive Compensation and First-Tier Subcontract Awards (Oct 2018)

52.209-6, Protecting the Government's Interest When Subcontracting with Contractors Debarred, Suspended, or Proposed for Debarment. (Oct 2015)

52.219-4, Notice of Price Evaluation Preference for HUBZone Small Business Concerns (OCT 2014)

52.219-6, Notice of Total Small Business Set-Aside (Nov 2011)

52.219-8, Utilization of Small Business Concerns (Oct 2018)

52.219-13, Notice of Set-Aside of Orders (Nov 2011)

52.219-14, Limitations on Subcontracting (Jan 2017)

52.219-28, Post Award Small Business Program Representation (Jul 2013)

52.222-3, Convict Labor (June 2003)

52.222-19, Child Labor-Cooperation with Authorities and Remedies (Jan 2018)

52.222-21, Prohibition of Segregated Facilities (Apr 2015)

52.222-26, Equal Opportunity (Sept 2016)

52.222-35, Equal Opportunity for Veterans (Oct 2015)

52.222-36, Equal Opportunity for Workers with Disabilities (July 2014)

52.222-37, Employment Reports on Veterans (Feb 2016)

52.222-40, Notification of Employee Rights Under the National Labor Relations Act (Dec 2010)

52.222-50, Combating Trafficking in Persons (Jan 2019)

52.222-54, Employment Eligibility Verification (OCT 2015)

52.223-18, Encouraging Contractor Policies to Ban Text Messaging While Driving (AUG 2011)

52.225-1, Buy American-Supplies (May 2014)

52.225-13, Restrictions on Certain Foreign Purchases (June 2008)

52.232-33, Payment by Electronic Funds Transfer-System for Award Management (Oct 2018)

Full text copies of the representations and certifications for other cited provisions and clauses may be obtained on line at the NCI website at http://ncioa.cancer.gov/oa-internet/

OFFERORS: Offers must be submitted with a completed 52.212-3 Offeror Representations and Certifications-Commercial Items-with DUNS Number Addendum, signed by an authorized representative of the offeror OR provide a copy of the valid SAM registration through www.sam.gov.

Quotations must be received in the NCI OA contracting office by 5:00 p.m. EST on July 16, 2019. Please refer to solicitation number 75N91019Q00057 on all correspondence. Faxed quotations will NOT be accepted. Quotations may be submitted via email to Kimesha Leake, Contracting Officer at Kimesha.leake@nih.gov . No collect calls will be accepted. In order to receive an award, Contractors must be registered and have valid certification in the System for Award Management through sam.gov.

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