Custom Synthesis of Peptide Inhibitors of Botulinum Neurotoxin

The United States Army Medical Research Acquisition Activity (USAMRAA) has a Firm Fixed Price type Service requirement to provide United States Army Medical Research Institute of Chemical Defense (USAMRICD) with the custom synthesis of 25 unique peptide inhibitors of Botulinum Neurotoxin catalytic domain.

These peptides will have novel couplings that make them resistant to cellular proteases and hydrocarbon quote mark staples quote mark that can maintain their alpha helical secondary structure without the use of more labile disulfide bonds. These peptide inhibitors will be tested in cell-free and cell-based assays, in isolated nerve-muscle preparations and in several animal models.

This work shall be performed as based on the Performance Work Statement included in the Solicitation. This requirement is Set-Aside for Small Businesses. The size standard classification is $14M, and the NAICS code is 541990.

All responsible sources may submit a quote, which shall be considered by the agency. The competitive solicitation, solicitation amendments and all questions and answers relating to this procurement shall be made available via the Internet at http://www.fedbizopps.gov.

The solicitation is anticipated for release to the vendor community on or about, 9 May 2014 and will only be available until 9 June 2014. Specifics of the requirement are provided in pending solicitation number: W81XWH-14-T-0207.

Potential offerors are responsible for accessing the website and responding to the solicitation in order to be considered for award of any resultant contract. To be eligible for an award, offerors MUST be registered with the System for Award Management (SAM) at http://www.sam.gov. The required Representations and Certification shall be made available under the SAM system.

Telephone requests will not be honored and bidder lists will not be maintained. Potential offerors are required to direct all questions regarding the requirement to the Contract Specialist at brandon.m.roebuck.civ@mail.mil by NO LATER THAN 3:30 PM EST on 23 May 2014.

All proposals are due to the Contract Specialist via e-mail to brandon.m.roebuck.civ@mail.mil by NO LATER THAN 3:30 PM EST on 9 June 2014.