6640--3D Bioprinter SOURCES SOUGHT BRAND NAME OR EQUAL (AND COMPATIBLE)

SOURCES SOUGHT FOR BRAND NAME OR EQUAL (and Compatible)

Regen-Hu R-GEN 200 1 EACH

R-GEN 200

3D bioprinting station with fully modular configuration in biosafe environment

including:

- 3D printing robot with closed-loop position control

- Instrument interface R-GEN CONTROLLER with multi-touch input

- Computer & Display (including keyboard & mouse)

- Tool calibration system and vacuum sample mounting system

- Built-in interface for Electrospinning and -Writing kit (ESK)

- Built-in interface for temperature control management system (TCD, TCS, WTP)

- Built-in optical fiber for integration of Substrate Height Calibration (SHC)

- Class II biosafety cabinet (Type A2) - NSF/ANSI 49

- Built-in ultraviolet germicidal lamp

3D bioprinting is an extended application of additive manufacturing in which involves building a tissue or organ layer-by-layer using a bottoms-up approach . The primary aim is to mimic the natural cellular architecture by depositing materials and cells in a particular fashion which can restore the normal structure and functionality of complex tissues. Because bioprinting deals with the living entities such as cells, tissues, etc., the modalities associated with the living tissues must be observed, such as biocompatibility of the material being used, cell sensitivity to the printing methods (therefore each printer head needs to be pressure and temperature controlled because we do not want to kill our cells!), growth factor delivery etc. Since this whole process is automated and sensitive, it can give precise patterning of cells with controlled extracellular matrix organization and because of this layer by layer construction of these bio printed tissues, they possess interconnected pores which are ideal for perfusion and nutrients.

Because of the versatility of bioprinting, several techniques have developed for selective patterning of cells and biomaterials for fabrication of viable tissue constructs such as inkjet-based 3D bioprinting, extrusion-based 3D bioprinting, laser assisted 3D bioprinting, and stereolithographic based 3D bioprinting. Typically, just one bioprinting technique exists in one instrument alone. However, with the Regen-Hu instrument, we get an all-in-one platform capable of producing ALL techniques in one platform. Because of the wide applications this instrument offers in one platform, productivity and efficiency is improved, preventing us from buying multiple bioprinters, each with its own technique, to satisfy our Principal Investigators requirements and allowing our principal investigators the ability to optimize their materials and techniques in a cost effective and timely manner. Additionally, we are very interested in collaborating with the VA Medical Center in Indiana who has this instrument. Compatibility between instruments is required so research being conducted will not have issues with biocompatibility.