MECs_Small_Laboratory_Animals_04-15-2019.pdf

ATTACHMENT A

SMALL LABORATORY ANIMALS

MINIMUM ESSENTIAL CHARACTERISTICS (MECs)

The Contractor shall provide small laboratory research animals that meet the following requirements:

1. Strains/models of Mice, Rats, Guinea Pigs, Hamsters, Rabbits, and Gerbils in accordance with its Commercial

Published Price List

2. The small laboratory animals must be at specified ages, genders, or weight requirements, for each species which are:

a. Weanlings through adult

b. Pregnant

c. Mothers with litters

d. Retired breeders

3. Must be Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) or

Canadian Council on Animal Care (CCAC) accredited prior to award of Blanket Purchase Agreement (BPA) and the accreditation must be maintained on throughout the ordering period of the BPA.

4. Animals must come from AAALAC or CACC accredited facilities. Contractor is required to provide the health documents of all animals upon request or with each shipment for all animals. The health document/summary should include information such as results and date of testing on sentinel.

5. Animals shall be negative for standard host-specific protozoa, viral, bacterial and parasitic agents, and specific for each species. This shall be monitored by the Contractor. If the Contractor’s colony does test positive, the Contractor shall notify the Contracting Officer and COR in writing within five (5) business days upon confirmation.

a. Mice shall be negative for

i. Sendai virus (SEND)

ii. Murine hepatitis virus (MHV)

iii. Lymphocytic choriomeningitis (LCMV)

iv. Mouse encephalitis (TMEV/GVII)

v. Reovirus 3 (REO3)

vi. Minute virus of mice (MVM)

vii. Pneumonia virus of mice (PVM)

viii. Mouse parvovirus (MPV), both MPV-1 and MPV-2

ix. Mouse Adenovirus (MAD), both MAD-1 and MAD-2

x. K Virus

xi. CAR Bacillus

xii. Ectromelia virus (ECTRO)

xiii. Mycoplasma pulmonis (MPUL)

xiv. EDIM (Rotavirus)

xv. Polyoma virus (POLY)

xvi. Fecal floatation results

xvii. Peri-anal tape test results,

xviii. Pelt/fur check for mites results

xix. Mouse Norovirus (MNV)

xx. Helicobacter

xxi. Hantavirus

xxii. Citrobacter rodentium

xxiii. Corynibacterium kutscheri

xxiv. Salmonella species

xxv. Streptobacillus moniliformis

xxvi. Encephalitozoon cuniculi (ECUN)

xxvii. Helminths

b. Rats shall be negative for

i. Sendi virus (SEND)

ii. Reovirus 3 (REO3)

iii. Pneumonia virus of mice (PVM)

iv. Sialodacryoadenitis virus (SDAV)

v. Kilham’s Rat virus (KRV)

vi. Toolan’s H-1 Parvovirus (H-1)

vii. Mycoplasma pulmonis (MPUL)

viii. Pneumocystis murinii

ix. Tyzzer’s disease

x. CAR Bacillus

xi. Streptobacillus moniliformis

xii. Helicobacter spp.

xiii. Rat parvovirus (RPV)

xiv. GDVII Rat Theilovirus (RTV)

xv. Hantavirus

xvi. Lymphocytic Choriomeningitis Virus (LCMV)

xvii. Adenoviruses (MAV)

xviii. Corynibacterium kutcheri

xix. Salmonella species

xx. Rat cytomegalovirus

xxi. Rat minute virus

xxii. Theiler's mouse encephalomyelitis virus

xxiii. Mycoplasma pulmonis

xxiv. Theilovirus

c. Guinea Pigs shall be negative for

ii. Reovirus 3 (REO3)

iii. Pneumonia virus of mice (PVM)

iv. Lymphocytic choriomeningitis (LCMV)

v. Bordetella

vi. Simian virus (SV-5)

vii. Adenovirus (GAV)

viii. Mycoplasma pulmonis

ix. Salmonella species

x. Streptococcus zooepidemicus

xi. Streptobacillius moniliformis

xii. Strep. pneumoniae

xiii. Tyzzer’s Disease

xiv. All ectoparasites

xv. Helminths (listed as Endoparasites on the health report)

xvi. Encephalitozoon cuniculus

xvii. Bordetella bronchiseptica

xviii. Cilia-associated respiratory bacillus (CAR bacillus)

d. Hamsters shall be negative for

ii. Pneumonia virus of mice (PVM)

iii. Reovirus 3 (REO3)

iv. Lymphocytic choriomeningitis (LCMV)

v. Mycoplasma

vi. Hamster parvovirus

vii. Bordetella bronchiseptica

viii. Hantaan virus

ix. Mycoplasma pulmonis

x. Salmonella

xi. Theiler's mouse encephalomyelitis virus

xii. Hamsters shall be group housed from birth to prevent/reduce future fighting between these animals after arrival at USAMRIID due to space availability.

xiii. Simian virus (SV-5) (Optional)

xiv. Lawsonia sp.

xv. Tyzzer’s disease

e. Rabbits shall be negative for

i. Bordetella

ii. Pasterurella multocida

iii. Tyzzer’s disease

iv. Serpulina cuniculi

v. Lawsonia intracellularis

vi. Pox viruses

vii. Calicivirus (RHDV)*

viii. Reovirus

ix. Lymphocytic choriomeningitis (LCMV)

x. Salmonella species

xi. Treponema species

xii. Encephalitozoon cuniculus

xiii. Cilia-associated respiratory bacillus (CAR bacillus)

xiv. Corynebacterium kutscheri

xv. Clostridium spiriforme

xvi. Helminthes

xvii. All ectoparasites

*Note that the Government will recognize USDA's designation of the USA as free from rabbit viral hemorrhagic disease (Calicivirus (RHDV)) and, therefore, Contractors that are USA-based breeders will be exempt from testing for this regulated disease under the resultant BPAs.

f. Gerbils shall be negative for

i. Tyzzer’s disease

ii. Lymphocytic choriomeningitis (LCMV)

iii. Helicobacter (Optional)

6. Animals must be of specified weight and proof of weight prior to shipment and shall provide the weight sheet with the shipment of the animals upon request. The shipping records shall include information such as gender, approximate ages, and quantities of each animal.