W81XWH-18-R-0059.docx

W81XWH18R0059

This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR 12.6, Streamlined Procedures for Commercial Items, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; Quotes are being requested and a written solicitation will not be issued. The solicitation number is W81XWH18-R-0059. The solicitation is issued as a request for quotation (RFQ). Provisions and clauses in effect through Federal Acquisition Circular 2005-97 are incorporated. It is the contractor’s responsibility to be familiar with the applicable clauses and provisions. The clauses may be accessed in full text at these addresses https://acquisition.gov/far/index.html and http://www.acq.osd.mil/dpap/sitemap.html. The NAICS code is 334516, with a small business size of 1,000 employees. This is a Full and Open Competition requirement; all qualified vendors are encouraged to submit a quote.

USAMRAA on behalf of the Armed Forces Medical Examiner System (AFMES) requests responses from qualified sources capable of providing Brand Name Only Illumina Brand Reagents, Test Kits, Consumable Supplies, and Instrumentation in accordance with the minimum essential characteristics (MECs), and Statement of Need (SON).

The resultant Blanket Purchase Agreement (BPA) will be on a DD 1155 which will not include any Contract Line Item Numbers (CLINS). Therefore, there are no CLINS included on this solicitation.

The Government intends to award one Blanket Purchase Agreement (BPA) contract, but may award multiple. Requirements will be procured via the award of call orders issued against the basic agreement(s). The minimum for each awardee is $500. 00. The maximum value of all call orders issued as result of this solicitation is $5,500,000.00.

Period of Performance:

Ordering Period – est: 25 September 2018 – 24 September 2023

Customer Location:

115 Purple Heart Drive Dover AFB, DE 19902

INSPECTION: Unless otherwise specified in the order, the offeror is responsible for the performance of all inspection requirements and quality control.

Other Administrative Instructions:

System for Award Management (SAM). Offerors must be registered in the SAM database to be considered for award. Registration is free and can be completed on-line at https://www.sam.gov/portal/public/SAM/; provide DUNS number; Cage Code and TIN.

Offerors are reminded to include a completed copy of 52.212-3 ALT I with RFQ response. All clauses shall be incorporated by reference in the order.

Quotes shall be submitted in accordance with the provision at 52.212-1, Instructions to Offerors—Commercial, and its addendum.

Quotes will be evaluated in accordance with the provision at 52.212-2, Evaluation—Commercial Items, and the specific evaluation criteria included in paragraph (a) of that provision.

Offerors are reminded to include a completed copy of 52.212-3, Offeror Representations and Certifications—Commercial Items ALT I with RFQ response. All clauses shall be incorporated by reference in the order.

The clause at 52.212-4, Contract Terms and Conditions—Commercial Items and 52.212-5, Contract Terms and Conditions Required To Implement Statutes or Executive Orders—Commercial Items, apply to this acquisition

The resulting Blank Purchase Agreement will be unrated with regards to the Defense Priorities and Allocations System (DPAS).

Questions: Questions must be received in writing (email) no later than July 19, 2018 at 1:00 P.M. Eastern Time. Questions should be submitted to kimberly.s.hannan.civ@mail.mil.

Due date: Quotes are due no later than August 7, 2018 at 1:00 P.M. Eastern Time and must be submitted in accordance with the instructions found in 52.212-1.

BPA ADMINISTRATION

1. PAYMENT

Payment procedures will be indicated on each Call Order.

2. CONTRACTING OFFICER’S REPRESENTATIVE (COR)

The COR for the resultant BPAs will be assigned via a separate appointment letter.

3. BPA MANAGEMENT

It is the contractor’s responsibility to notify the Contracting Officer (KO) immediately if there are any administrative changes such as contact information. Additionally, the contractor shall immediately contact the KO to request clarification when a question arises regarding the authority of any person to act for the KO under the resultant BPAs.

4. INTERPRETATION OF MODIFICATION

No verbal or written statement by any person other than the KO, or his/her authorized representative acting within the scope of his/her authority, shall be interpreted as modifying or otherwise affecting the terms of this solicitation as the resultant BPAs. All requests for amendments/modifications shall be made in writing to the KO or Contract Specialist.

5. ORGANIZATIONAL CONFLICT OF INTEREST (OCI)

If any OCI arises during the Period of Performance, the vendor shall notify the Contracting Officer in writing. Please be advised that the Government may not make an award that would result in a prohibited OCI. Therefore, offerors shall identify any and all potential OCI that arises from performing any aspects of the requirement as detailed in the SON and MEC’s, and include proposed means of preventing, avoiding or mitigating each OCT identified.

6. QUALITY ASSURANCE SURVEILLANCE PLAN (QASP)

The Government will review monthly performance with the contractor to survey the quality of products and services according to the QASP. Note that this is a living document and the Government may review and revise the QASP on a regular basis to ensure that it remains a valid, useful, and enforceable document. However, the Government will coordinate changes with the contractor. Copies of the original QASP and revisions will be provided to the contractor and Government officials implementing surveillance actives.

7. SITE VISITS

The Government reserves the right to conduct an onsite visit to the offerors location to determine if the facility meets the requirements.

7. ANNUAL BPA REVIEWS

The resultant BPAs will be reviewed annually, in accordance with FAR 13.303-6 to ensure that authorized procedures are being followed and to determine if updates and/or modifications to existing terms and conditions are appropriate.

8. CALL ORDERS

8.1. The contractor shall perform in accordance with the agreement schedule and as called for by Orders issued in accordance with the following procedures.

8.2. The DD 1155 or SF 1449 will be used to issue Call Order assignments and to signify Contracting Officer notification to commence work under the individual Call Orders. The contract shall not proceed with the Call Order assignments until notification is received from the Contracting Officer or authorized GPC Ordering Officers.

8.3. The Call Orders, and modifications to Call Orders, will be numbered by the issuing office. Modifications to the Call Order will be designated by the modification number and contain the original Call Order number.

9.4. The contractor shall identify all correspondence, reports, drawings, and other pertinent papers in connection with the BPA by imprinting thereon the Call Order and the BPA number, plus any other references furnished by the Contracting Officer.

8.5. The total of all completed and outstanding Call orders will at no time exceed the current amount of obligated.

8.6. The Competition Advocate for the U.S. Army Medical Research Material Command, Fort Detrick, Maryland has been designated as the Ombudsman for this BPA.

8.7. Procedures:

8.7.1. Prior to issuance of a Call Order and upon definition of the Government requirement either

a. the Contract Specialist will, in writing, issue to the contractors a Call Order Request for Quote (RFQ), or

b. an authorized GPC Ordering Officer will, in writing or verbally, issue to the contractors a Call Order RFQ.

8.7.2. The contractor shall provide its Call Order quote to the Contract Specialist or authorized GPC Ordering Officer by a date mutually agreed upon but no later than five (5) working days after receipt of the RFQ, unless otherwise specified.

8.7.3. The Government will award a Call Order to the offeror whose proposal is deemed most advantageous to the Government based upon the evaluation factors defined in the Call Order RFQ.

10. BPA CEILING

The cumulative ceiling price of all BPAs issued against this solicitation will be $5,500,000.00. The contractor agrees that the work performed under the resultant BPAs shall be accomplished within the specified ceiling price. Unless and until the Contracting Officer has notified the contractor in writing that the ceiling price has been increased and the amount of the increase, any cost incurred in excess of the ceiling price shall be borne by the contractor. Contractor entitlement to the monies specified as the BPA ceiling is derived solely from the issuance and successful performance of Call Orders against that ceiling amount.

SUPPLIES AND PRICES

1. AGREEMENT

1.1. The acquisition is unrestricted for Brand Name Only Illumina reagents, kits, consumable supplies and instrumentation with NAICS code of 334516 – Analytical Laboratory Instruments.

1.2. The resultant Blanket Purchase Agreements (BPAs) will be on a DD 1155 or SF1449 which will not include any Contract Line Item Numbers (CLINS). Therefore, there are no CLINS included on this solicitation. A random sample of items have been included as Attachment A – Items List.

1.3. The Government expects to award a single BPA resulting from this solicitation. All resultant Call Orders will be Firm Fixed Price.

1.4. The ordering period for this BPA is a five (5) year ordering period. In accordance with (IAW) the Federal Acquisition Regulation (FAR) 13.303-6(b) the Contracting Officer will review the BPA annually to ensure compliance with the terms and conditions and to determine if updates and/or modifications to existing terms and conditions are appropriate.

2. EXTENT OF OBLIGATIONS

2.1. The Government is obligated only to the extent of authorized purchases ordered and received under the resultant BPAs.

3. ISSUANCE OF CALL ORDERS

3.1. All deliveries under the resultant BPA will be set forth in individual Call Orders. All Orders will be issued in accordance with (IAW) the requirements and all clauses listed in this solicitation.

3.2. The anticipated collective maximum amount of all Call Orders issued against the resultant BPA for the five (5) year ordering period will not exceed $5,500,000.00 per section 10 of BPA ADMINISTRATION listed in this solicitation.

3.3. Orders placed by the GPC Ordering Officers using a Government Purchase Card (GPC) will not exceed $25,000.00. All orders above $25,000.00 must be issued by a Call Order signed by the Contracting Officer with payment being made through Wide Area Workflow (WAWF).

3.4. The ceiling amount for this BPA is $5,500,000.00 which includes the maximum collective amount of all Call Orders for the ordering periods identified in Section 1.4. Any costs incurred in excess above the ceiling amount of $5,500,000.00 will be borne by the Contractor. The Contractor agrees all supplies delivered under this BPA will be accomplished within the ceiling amount.

4. Individuals Authorized to Purchase under the BPA

4.1. This BPA is available for use by the entire Department of Defense (DoD) medical/research community; however, all purchases must be coordinated through the Contracting Office.

4.2 The following individuals are authorized to make purchases under this BPA:

a. Contracting Officer, U.S. Army Medical Research Acquisition Activity (USAMRAA)

b. Government Purchase Card (GPC) Ordering Officers for the Armed Forced Medical Examiner System (AFMES)

4.3. The required supplied provided under this BPA will be set forth in individual Call Orders and verbal order are authorized for the GPC Ordering Officer and the Contracting Officer. Call Orders issued by the Contracting Officer will be on the DD1155 or the SF 1449.

5. Delivery Tickets

5.1. All shipments under this BPA shall be accompanied by delivery tickets or sales slips that contain the following minimum information:

f. Quantity, unit price, and extension of each item, less applicable discounts (unit prices, and extensions need not be shown when incompatible with the use of automated systems, provided that the invoice is itemized to show this information)

g. Date of delivery or shipment

5.2. Individual Call Orders and GPC orders may identify additional shipment instructions above what is identified in 5.1 above.

6. Invoices

6.1. The Contractor will be required to submit an itemized invoice at a minimum upon delivery of consumables.

6.2. All Contractor invoices will be submitted utilizing the Wide Area Workflow (WAWF) in accordance with Defense Federal Acquisition Regulation Supplement (DFARS) 252.232-7003 and DFARS 252.232-7006. In addition, the Contractor will all payment of the invoices by GPC.

6.3 Invoicing Questions: Questions regarding payment of invoices submitted WAWF should be directed to the Defense Finance Accounting Service (DFAS), Indianapolis (INDY) Tricare Management Activity (DAI/TMA) at 1-888-332-7366 (Option 2) or 317-510-0300 (Option 2). Email: DFAS-IN.97.VPIS@DFAS.MIL. All questions pertaining to posting an invoice to WAWF should be directed to the WAWF Help Desk at 866-618-5988.

6.4. Reference WAWF Websites:

6.5. Invoices submitted to WAWF must include:

7. Shipping and Handling

Shipping shall be Free on Board (FOB) Destination IAW FAR 52.247-34. The Shipping location will be defined in the Call Order or by the GPC Ordering Official.

STATEMENT OF NEED

Brand Name Illumina Reagents, Kits, Consumable Supplies, and Instrumentation

1. Scope

1.1. This BPA provides for the purchase of DNA Identification reagents and consumable supplies manufactured by Illumina to support the Armed Forces Medical Examiner System (AFMES), DNA Identification Laboratory (AFDIL), mission in AFDIL’s ancient remains DNA identification mission, For scientific and programmatic consistency, AFMES must complete ongoing multiyear research projects under OTSG/MEDCOM Policy 15-042 using the NextSeq and MiSeq Systems with their respective proprietary reagents and consumables.

1.2. The supply Statement of Need (SoN) has been reviewed and contains no supplies and services that are inherently governmental functions, as defined in the Federal Acquisition Regulation (FAR) Part 2.1. The general scope of this supply requirement is to procure supplies required to support the AFDIL’s mission at the customers’ location in Dover AFB, DE.

1.3. This BPA is available for use by the entire DOD medical community. However please refer to the authorized ordering offices listed below (see Section 5 of the SON). Delivery of consumables will be made based on the delivery instructions provided at the time of Call Order award or by the Government Purchase Card (GPC) Ordering Officer.

2. OBJECTIVE

2.1. The objective of this single award BPA requirement is to purchase reagent test kits, consumable supplies, and instruments manufactured by Illumina Inc. in support of AFDIL’s mission AFDIL’s ancient remains DNA identification mission, For scientific and programmatic consistency, AFMES must complete ongoing multiyear research projects under OTSG/MEDCOM Policy 15-042 using the NextSeq and MiSeq Systems with their respective proprietary reagents and consumables. Illumina is the only source that can meet the Government’s requirement for reagents and supply kits for the NextSeq and MiSeq Systems. By prior acquisition, AFMES, acquired Illumina MiSeq, Illumina NextSeq, Illumina TruSeq DNA, and Illumina Nextera equipment. Collectively, the instrumentation consists of sequencing analyzers to include proprietary software to support expansion to another Illumina platform. AFMES has an ongoing need to acquire additional equipment to facilitate increased output and to ensure backup instrumentation in the event of primary analyzer equipment failure. The Illumina proprietary consumable kits and reagents are compatible only with Illumina proprietary systems.

The following is a random sample of items used with the Illumina MiSeq Next Generation Sequencer, shall have the following Minimum Essential Characteristics: Ilumina part numbers are listed as the minimum essential characteristics.

ForenSeq DNA Signature Prep Kit (384 rxns) Illumina # TG-450-1001

MiSeq FGx Reagent Kit (600 cycles) Illumina # TG-143-1001

MiSeq Reagent Kit v3 (150 cycles) Illumina # MS-102-3001

MiSeq Reagent Kit v3 (600 cycles) Illumina # MS-102-3003

Nextera XT DNA Sample Preparation Kit, 96 samples Illumina # FC-131-1096

Nextera XT Index Kit (96 indices, 384 samples) Illumina # FC-131-1002

PhiX Control v3 Illumina # FC-110-3001

MiSeq Reagent Kit v2 - 300 cycle Illumina # MS-102-2002

NextSeq 550 Sequencing System Illumina # SYS-415-1002

2.2 Illumina is the only source that can meet the Government’s requirement for reagents and supply kits for the NextSeq and MiSeq Systems. By prior acquisition, AFMES, acquired Illumina MiSeq, Illumina NextSeq, Illumina TruSeq DNA, and Illumina Nextera equipment. Collectively, the instrumentation consists of sequencing analyzers to include proprietary software to support expansion to another Illumina platform. AFMES has an ongoing need to acquire additional equipment to facilitate increased output and to ensure backup instrumentation in the event of primary analyzer equipment failure. The Illumina proprietary consumable kits and reagents are compatible only with Illumina proprietary systems. For scientific and programmatic consistency, AFMES must complete ongoing multiyear research projects under OTSG/MEDCOM Policy 15-042 using the NextSeq and MiSeq Systems with their respective proprietary reagents and consumables. In order to maintain data integrity, future supplies must conform to the standardization requirements of already validated data that is part of existing research protocols. The established standardized baseline of these reagents is integral to maintaining the ISO Accreditation. In-process projects have used these reagents to maintain a validated data set, therefore, to maintain scientific continuity it is imperative that the end-user continue to use Illumina proprietary Brand Name reagents, consumables, and instrumentation.

3. Period and Place of Delivery Requirements

3.1. The proposed Period of Performance for this BPA will be a Five (5) year ordering period beginning on or about 25 September 2015.

3.2. Place of delivery. The primary delivery location will be AFMES, 115 Purple Heart Drive, Dover AFB, DE 19902. However, as this BPA will be open to the entire DOD medical community, multiple delivery locations could be expected.

4. Inspection and Acceptance

4.1. Certification by the Government of satisfactory goods provided is contingent upon the vendor performing in accordance with the terms and conditions of the resultant BPA and all Call Orders issued against the BPA. Items will be returned to the vendor is they do not meet specifications specified in the Call Order at receipt inspection.

4.2 The Government point of contact (POC) may reject or require correction of any deficiencies found in the invoice or receiving report. In the event of a rejected invoice or receiving report, the vendor will be notified in writing by the Government POC with the specific reasons for rejection.

5. Authorized Agencies

The following offices are hereby authorized to place Orders under the resultant BPAs:

U.S. Army Medical Research Acquisition Activity (USAMRAA) 820 Chandler Street Fort Detrick, MD 21702

Armed Forces Medical Examiner System (AFMES) 115 Purple Heart Drive Dover AFB, DE 19902

The USAMRAA Contracting Officer and the GPC Ordering Officers will be the only authorized buyers under this BPA. USAMRAA will be authorized to place Orders for other agencies under the Medical Research Material Command and other DOD medical agencies, as needed. The position titles of the appointed GPC Ordering Officers will be provided at the time of BPA award.

Orders by other individuals will not be honored without prior written approval from the USAMRAA Contracting Officer.

6. Contractor Quarterly Report

The contractor shall provide an electronic quarterly report of GPC Orders within 15 calendar days after the close of each quarter (31 March; 30 June; 30 September; 31 December). The reports shall include Orders placed from the first day of the quarter to the last day of the quarter. Reports shall reflect, at a minimum, the following information:

Unique Order Number Date of Order Item Description(s) Total Dollar Amount of Each Order Authorized Ordering Official’s Name

If no GPC Orders were made in a given quarter, the contractor shall send a report or email stating such. Reports shall be sent via email to Kimberly Hannan at kimberly.s.hannan.civ@mail.mil

8. Deliverables

The contractor shall provide electronic copies of the deliverables as described in the below table and in accordance with submission requirements. Deliverables shall be specified by the Government.

MEC

MECs for Brand Name Only -Illumina

General: The following consumables are required for operation of, and DNA sample preparation for, the Illumina MiSeq instrument installed at the Armed Forces DNA Identification Laboratory.

Part I. Kits necessary for DNA library preparation

Depending on the sample and the application, various protocols and kits are required to create DNA libraries compatible with the Illumina MiSeq sequencer. Libraries built for both single-read and paired-end reads can be sequenced on the MiSeq instrument.

1. Nextera XT DNA Sample Preparation Kit (FC-131-1096)

Nextera XT is a DNA sample preparation kit required for simplified and ultra-fast preparation of DNA libraries ready to be applied to a MiSeq cartridge for sequencing. The kit is required for use with pristine DNA specimens and eliminates the need for the separate and time-consuming DNA shearing and adaptor ligation steps. The kit includes all reagents and supplies required to fragment, blunt-end repair, phosphorylate, and adenylate samples, and to ligate Illumina-specific adapters to DNA templates. Adapters in these kits are specific to the Illumina MiSeq Platform. The associated Nextera indices serve as sample identifiers and are required for the processing of more than one sample at a time. Each workflow requires both the sample preparation kit and associated index kit:

Nextera XT DNA Sample Preparation Kit (96 samples): (FC-131-1096) Associated Nextera XT Index Kit (96 Indices, 384 Samples): FC-131-1002

Specifications:

- Nextera XT DNA Sample Preparation Kit must contain: Tagment DNA Buffer, Tagment DNA enzyme, Nextera PCR Master Mix, PCR Primer cocktail with MiSeq-specific primers, and resuspension buffer.

-Associated Nextera XT Index kit must contain: Index primers, custom Illumina N501 to N508 and Index primers, and Illumina specific N701 to N712.

- Protocol must be performed in 90 minutes or less.

- Kit must eliminate the need for mechanical fragmentation/shearing of DNA sample.

- Kit must contain enough reagent volumes for a minimum of 96 samples.

- Kit must accommodate as little as 50ng input DNA.

- Kit must create dual-indexed samples to maximize sample throughput using MiSeq’s paired-end read capability.

1. ForenSeq DNA Signature Prep Kit - 384 rxns (TG-450-1001)

The ForenSeq DNA Signature Prep Kit supports preparation of up to 96 libraries simultaneously using a simple plate-based format and standard lab equipment. Targeted primer mixes enable analysis of autosomal, Y- and X-chromosome short tandem repeat (STR) targets, and identity-informative SNPs, all in a single reaction.

1. MiSeq FGx Reagent Kit - 600 cycles (TG-143-1001)

Provides reagents for up to 398 cycles of sequencing, which is sufficient for351 + 31 cycles plus two eight-cycle index reads. Analyzes a dense set of forensically relevant markers at low, medium, or high sample throughput by using pre-filled, ready-to-use reagent cartridges, and offers the improved v3 chemistry to increase cluster density and read length as well as improve quality.

Part II. Kits necessary for cluster generation and sequencing by synthesis

1. MiSeq Reagent Kit v.2 - 300 cycles (MS-102-2002)

This kit is required for bridge amplification and up to 300 cycles of reversible dye-terminator sequencing on the Illumina MiSeq platform. 300 cycle reads are required for sequencing of the short tandem repeat markers (STRs) and other repetitive regions regularly employed in AFDIL casework.

1. MiSeq Reagent Kit v.3 – 150 cycles (MS-102-3001)

This kit is required for bridge amplification and up to 150 cycles of reversible dye-terminator sequencing on the Illumina MiSeq platform. 150 cycle reads are required for sequencing of the short tandem repeat markers (STRs) and other repetitive regions regularly employed in AFDIL casework. The large size of these markers precludes the use of the 300 cycle reagent kit for paired end reads. Version 3 chemistry also allows double the output per flow cell compares to version 2 reagent kits, potentially allowing higher throughput per run and greater coverage per sample.

Specifications:

-The kit must contain: one Illumina single-use pre-filled cartridge, Hybridization Buffer, Incorporation Buffer and a Single-use flow cell.

-Each cartridge must contain single-use consumables consisting of foil-sealed reservoirs pre-filled with the following reagents required for sequencing: Incorporation Mix, Scan Mix, Cleavage Mix, Amplification Mix, Read 2 Amplification Mix, Linearization Premix, Formamide, Linearization Mix, Read 2 Linearization Mix, Resynthesis Mix, Read 1 Primer Mix, Index Primer Mix, and Read 2 Primer Mix.

- All reagents must be provided in a cartridge compatible with the MiSeq instrument.

- Cartridge must include a designated reservoir for user-prepared sample

- Must provide sufficient reagents for up to 150 cycles of sequencing.

1. MiSeq Reagent Kit v.3 – 600 cycles (MS-102-3003)

This kit is required for bridge amplification and up to 625 cycles of reversible dye-terminator sequencing on the Illumina MiSeq platform. 600 cycle reads are required for sequencing of the short tandem repeat markers (STRs) and other repetitive regions regularly employed in AFDIL casework. The large size of these markers precludes the use of the 300 cycle reagent kit for paired end reads. Version 3 chemistry also allows double the output per flow cell compares to version 2 reagent kits, potentially allowing higher throughput per run and greater coverage per sample.

Specifications:

-The kit must contain: one Illumina single-use pre-filled cartridge, Hybridization Buffer, Incorporation Buffer and a Single-use flow cell.

-Each cartridge must contain single-use consumables consisting of foil-sealed reservoirs pre-filled with the following reagents required for sequencing: Incorporation Mix, Scan Mix, Cleavage Mix, Amplification Mix, Read 2 Amplification Mix, Linearization Premix, Formamide, Linearization Mix, Read 2 Linearization Mix, Resynthesis Mix, Read 1 Primer Mix, Index Primer Mix, and Read 2 Primer Mix.

- All reagents must be provided in a cartridge compatible with the MiSeq instrument.

- Cartridge must include a designated reservoir for user-prepared sample

- Must provide sufficient reagents for up to 625 cycles of sequencing.

1. PhiX Control Kit v.3 (FC-110-3001)

PhiX, a bacterial genome, serves as a control sample and is required to monitor sequencing efficiency and reagent/instrument performance across multiple cluster generation and sequencing runs.

Specifications:

· Must be a small genome, enabling quick alignment and estimation of error rates.

· genome must contain approximately 45% GC and 55% AT

· Must have a well-defined genome sequence as Illumina cluster generation algorithms are optimized around a balanced representation of A, T, G, and C nucleotides.

· must be shipped as a ready-to-use 10 nM library.

5. NextSeq® 550 Sequencing System Purpose: The NextSeq® 550 Sequencing System is a next generation sequencing (NGS) system specifically designed for high-through-put sequencing and microarray scanning in an integrated benchtop unit. Its fast, integrated DNA-analysis workflow allows for the rapid sequencing of exomes, targeted panels in a single run, and has the capability of switching to a lower-through-put sequencing as needed. The unit has the flexibility to run high quality and degraded samples and utilize both 75 cycle and 150 cycle sequencing runs. The system utilizes dedicated library preparation kits, customized instrument control software, and an analytical software package to support the reliable analysis of both routine and challenging (degraded) forensic samples.

Specifications:

· Must be next generation sequencing (NGS) based platform incorporating cluster generation, sequencing, and Array scanning into a single instrument, and offers a seamless transition for onsite data analysis. Must link library preparation, sequencing, data analysis and reporting into a single, integrated, workflow

· Must ensure data quality via reversible terminator-based methods to sequence millions of DNA fragments, detecting single bases as they are incorporated into growing DNA strands

· Must have developed and validated indicators to ensure optimal sequencing results.

· Must have ability to provided High and Mid-Output flow cells with the ability to support read lengths of 2 x 75 bp and 2 x 150 bp, while having a Q30 of greater than 75%.

· Must support both single read and paired-end reads on both the high output and mid output kit and have up to 400 million reads for single reads and up to 800 million reads for paired end (High output) and up to 130 million single reads and up to 260 million reads paired end reads (mid out-put kit).

· Must meet at a minimum the following read length, time, and output for high and mid outputs.

· Must support the Infinium bead chip, specifically, the 850K.

· Must allow for real-time run monitoring and status reports

· Ready-to-use kits must be available for DNA library preparation for sequencing

· Ready-to-use sequencing kits must be available containing all reagents/consumables for use with sequencing-ready DNA libraries

· Shall incorporate touch screen interface

· Shall incorporate RFID tracking for consumables

· Instrument Control Computer (Internal) must be equivalent to:

0. Dual Intel Xeon ES-2448L 1.8 GHz CPU

0. 96 GB RAM

0. 750 GB Hard Drive

0. Windows 7 embedded standard

· Must have overall dimensions no greater than 21.0 in × 25.0 in × 23.0 in

· Voltage: 100 to 120 V

· Current: 15A (max)

· Frequency: 13.56 MHz

· Max BTU/h < 2048

· Gross total weight of no more than 183 lbs

DELIVERY INFORMATION

CLAUSES INCORPORATED BY REFERENCE

CLAUSES INCORPORATED BY FULL TEXT

52.212-1 INSTRUCTIONS TO OFFERORS--COMMERCIAL ITEMS (JAN 2017)

(a) North American Industry Classification System (NAICS) code and small business size standard. The NAICS code and small business size standard for this acquisition appear in Block 10 of the solicitation cover sheet (SF 1449). However, the small business size standard for a concern which submits an offer in its own name, but which proposes to furnish an item which it did not itself manufacture, is 500 employees.

(b) Submission of offers. Submit signed and dated offers to the office specified in this solicitation at or before the exact time specified in this solicitation. Offers may be submitted on the SF 1449, letterhead stationery, or as otherwise specified in the solicitation. As a minimum, offers must show--

(1) The solicitation number;

(2) The time specified in the solicitation for receipt of offers;

(3) The name, address, and telephone number of the offeror;

(4) A technical description of the items being offered in sufficient detail to evaluate compliance with the requirements in the solicitation. This may include product literature, or other documents, if necessary;

(5) Terms of any express warranty;

(6) Price and any discount terms;

(7) "Remit to" address, if different than mailing address;

(8) A completed copy of the representations and certifications at FAR 52.212-3 (see FAR 52.212-3(b) for those representations and certifications that the offeror shall complete electronically);

(9) Acknowledgment of Solicitation Amendments;

(10) Past performance information, when included as an evaluation factor, to include recent and relevant contracts for the same or similar items and other references (including contract numbers, points of contact with telephone numbers and other relevant information); and

(11) If the offer is not submitted on the SF 1449, include a statement specifying the extent of agreement with all terms, conditions, and provisions included in the solicitation. Offers that fail to furnish required representations or information, or reject the terms and conditions of the solicitation may be excluded from consideration.

(c) Period for acceptance of offers. The offeror agrees to hold the prices in its offer firm for 30 calendar days from the date specified for receipt of offers, unless another time period is specified in an addendum to the solicitation.

(d) Product samples. When required by the solicitation, product samples shall be submitted at or prior to the time specified for receipt of offers. Unless otherwise specified in this solicitation, these samples shall be submitted at no expense to the Government, and returned at the sender's request and expense, unless they are destroyed during preaward testing.

(e) Multiple offers. Offerors are encouraged to submit multiple offers presenting alternative terms and conditions, including alternative line items (provided that the alternative line items are consistent with subpart 4.10 of the Federal Acquisition Regulation), or alternative commercial items for satisfying the requirements of this solicitation. Each offer submitted will be evaluated separately.

(f) Late submissions, modifications, revisions, and withdrawals of offers:

(1) Offerors are responsible for submitting offers, and any modifications, revisions, or withdrawals, so as to reach the Government office designated in the solicitation by the time specified in the solicitation. If no time is specified in the solicitation, the time for receipt is 4:30 p.m., local time, for the designated Government office on the date that offers or revisions are due.

(2)(i) Any offer, modification, revision, or withdrawal of an offer received at the Government office designated in the solicitation after the exact time specified for receipt of offers is “late” and will not be considered unless it is received before award is made, the Contracting Officer determines that accepting the late offer would not unduly delay the acquisition; and--

(A) If it was transmitted through an electronic commerce method authorized by the solicitation, it was received at the initial point of entry to the Government infrastructure not later than 5:00 p.m. one working day prior to the date specified for receipt of offers; or

(B) There is acceptable evidence to establish that it was received at the Government installation designated for receipt of offers and was under the Government's control prior to the time set for receipt of offers; or

(C) If this solicitation is a request for proposals, it was the only proposal received.

(ii) However, a late modification of an otherwise successful offer, that makes its terms more favorable to the Government, will be considered at any time it is received and may be accepted.

(3) Acceptable evidence to establish the time of receipt at the Government installation includes the time/date stamp of that installation on the offer wrapper, other documentary evidence of receipt maintained by the installation, or oral testimony or statements of Government personnel.

(4) If an emergency or unanticipated event interrupts normal Government processes so that offers cannot be received at the Government office designated for receipt of offers by the exact time specified in the solicitation, and urgent Government requirements preclude amendment of the solicitation or other notice of an extension of the closing date, the time specified for receipt of offers will be deemed to be extended to the same time of day specified in the solicitation on the first work day on which normal Government processes resume.

(5) Offers may be withdrawn by written notice received at any time before the exact time set for receipt of offers. Oral offers in response to oral solicitations may be withdrawn orally. If the solicitation authorizes facsimile offers, offers may be withdrawn via facsimile received at any time before the exact time set for receipt of offers, subject to the conditions specified in the solicitation concerning facsimile offers. An offer may be withdrawn in person by an offeror or its authorized representative if, before the exact time set for receipt of offers, the identity of the person requesting withdrawal is established and the person signs a receipt for the offer.

(g) Contract award (not applicable to Invitation for Bids). The Government intends to evaluate offers and award a contract without discussions with offerors. Therefore, the offeror's initial offer should contain the offeror's best terms from a price and technical standpoint. However, the Government reserves the right to conduct discussions if later determined by the Contracting Officer to be necessary. The Government may reject any or all offers if such action is in the public interest; accept other than the lowest offer; and waive informalities and minor irregularities in offers received.

(h) Multiple awards. The Government may accept any item or group of items of an offer, unless the offeror qualifies the offer by specific limitations. Unless otherwise provided in the Schedule, offers may not be submitted for quantities less than those specified. The Government reserves the right to make an award on any item for a quantity less than the quantity offered, at the unit prices offered, unless the offeror specifies otherwise in the offer.

(i) Availability of requirements documents cited in the solicitation. (1)(i) The GSA Index of Federal Specifications, Standards and Commercial Item Descriptions, FPMR Part 101-29, and copies of specifications, standards, and commercial item descriptions cited in this solicitation may be obtained for a fee by submitting a request to--GSA Federal Supply Service Specifications Section, Suite 8100, 470 East L'Enfant Plaza, SW, Washington, DC 20407, Telephone (202) 619-8925, Facsimile (202) 619-8978.

(ii) If the General Services Administration, Department of Agriculture, or Department of Veterans Affairs issued this solicitation, a single copy of specifications, standards, and commercial item descriptions cited in this solicitation may be obtained free of charge by submitting a request to the addressee in paragraph (i)(1)(i) of this provision. Additional copies will be issued for a fee.

(2) Most unclassified Defense specifications and standards may be downloaded from the following ASSIST websites:

(i) ASSIST (https://assist.dla.mil/online/start/).

(ii) Quick Search (http://quicksearch.dla.mil/).

(iii) ASSISTdocs.com (http://assistdocs.com).

(3) Documents not available from ASSIST may be ordered from the Department of Defense Single Stock Point (DoDSSP) by--

(i) Using the ASSIST Shopping Wizard (https://assist.dla.mil/wizard/index.cfm);

(ii) Phoning the DoDSSP Customer Service Desk (215) 697-2179, Mon-Fri, 0730 to 1600 EST; or

(iii) Ordering from DoDSSP, Building 4, Section D, 700 Robbins Avenue, Philadelphia, PA 19111-5094, Telephone (215) 697-2667/2179, Facsimile (215) 697-1462.

(4) Nongovernment (voluntary) standards must be obtained from the organization responsible for their preparation, publication, or maintenance.

(j) Unique entity identifier. (Applies to all offers exceeding $3,500, and offers of $3,500 or less if the solicitation requires the Contractor to be registered in the System for Award Management (SAM) database.) The Offeror shall enter, in the block with its name and address on the cover page of its offer, the annotation ``Unique Entity Identifier'' followed by the unique entity identifier that identifies the Offeror's name and address. The Offeror also shall enter its Electronic Funds Transfer (EFT) indicator, if applicable. The EFT indicator is a four-character suffix to the unique entity identifier. The suffix is assigned at the discretion of the Offeror to establish additional SAM records for identifying alternative EFT accounts (see subpart 32.11) for the same entity. If the Offeror does not have a unique entity identifier, it should contact the entity designated at www.sam.gov for unique entity identifier establishment directly to obtain one. The Offeror should indicate that it is an offeror for a Government contract when contacting the entity designated at www.sam.gov for establishing the unique entity identifier.

(k) System for Award Management. Unless exempted by an addendum to this solicitation, by submission of an offer, the offeror acknowledges the requirement that a prospective awardee shall be registered in the SAM database prior to award, during performance and through final payment of any contract resulting from this solicitation. If the Offeror does not become registered in the SAM database in the time prescribed by the Contracting Officer, the Contracting Officer will proceed to award to the next otherwise successful registered Offeror. Offerors may obtain information on registration and annual confirmation requirements via the SAM database accessed through https://www.acquisition.gov.

(l) Debriefing. If a post-award debriefing is given to requesting offerors, the Government shall disclose the following information, if applicable:

(1) The agency's evaluation of the significant weak or deficient factors in the debriefed offeror's offer.

(2) The overall evaluated cost or price and technical rating of the successful and the debriefed offeror and past performance information on the debriefed offeror.

(3) The overall ranking of all offerors, when any ranking was developed by the agency during source selection.

(4) A summary of the rationale for award;

(5) For acquisitions of commercial items, the make and model of the item to be delivered by the successful offeror.

(6) Reasonable responses to relevant questions posed by the debriefed offeror as to whether source-selection procedures set forth in the solicitation, applicable regulations, and other applicable authorities were followed by the agency.

(End of provision)

ADDENDUM TO 52.212-1

ADDITIONAL INSTRUCTIONS TO OFFERORS

1. TECHNICAL QUESTIONS AND PRE-PROPOSAL DISCUSSION

Questions concerning the solicitation are due no later than 17 July 2018 at 10:00 AM Eastern Time. Questions shall be submitted to Ms. Kimberly Hannan at kimberly.s.hannan.civ@mail.mil An amendment to the solicitation will be posted in order to address the questions received; however, no questions will be addressed after the cutoff date and time listed above. Please note that only one (1) set of questions per Offeror will be accepted by the Government.

2. INSTRUCTIONS FOR THE PREPARATION AND SUBMISSION OF PROPOSALS

Failure to submit all documents concurrently and in accordance with these instructions may render a proposal unacceptable. Proposals are due no later than 7 August 2018 at 10:00 AM Eastern Time. The proposal shall be submitted electronically via email to both email addresses listed above kimberly.s.hannan.civ@mail.mil no later than the date and time specified on the cover page of this solicitation.

3. PROPOSAL EVALUATION

To aid in evaluation, proposals shall be practical, specific complete, and logically assembled. The proposal shall be in a clear, concise format satisfying all requirements of this solicitation. It shall be in sufficient detail to demonstrate a complete understanding of the work to be accomplished.

4. THE PROPOSAL

The overall proposal shall consist of two (2) separate volumes, individually titled. Each volume shall be appropriately titled, as follows:

Volume I shall be broken up into four (4) sections: Executed Solicitation Documents, Executive Summary, Technical, and Past Performance information (excluding the completed past performance questionnaires submitted from past performance references). The entirety of Volume I, shall not exceed fifty (50) pages, including appendices, matrices, and tables. Fold-outs (either 8 ½” by 14” or 11” x 17”) shall count as two (2) pages each. Proposals shall be typed in 12-point, Times New Roman font using 1” margins on the top, bottom and sides. Graphics, tables and matrices are exempt from the 12-point font requirement. The Table of Contents, Solicitation, tabs and index sheets will not be counted towards the page limits listed above. Any pages exceeding the page limitation or any pages containing materials not legible to the evaluators will be disregarded and will not be evaluated.

There are no page limitations for Volume II of the proposal. However, an electronic copy of the Offeror’s Commercial Published Price List, including any additional discounts off of their current pricing, shall be submitted as part of Volume II.

4.1. Contents of the Technical Proposal (Volume I)

All sections of the Offeror’s Technical Proposal shall make direct reference to the Reagents and Consumables within the SON and MECs section paragraph numbers, if applicable. The Proposal shall be presented in a clear and logical order.

Statements such as “will comply”, “meets the intent of”, or “we intend to meet the requirements” and the like, will NOT suffice for evaluation purposes.

Section 1 – Executed Section 1 shall contain a completed copy of Representations and Certifications

Section 2 – Executive Summary The Executive Summary shall not exceed one (1) page and should briefly summarize the content and identify the key points of the Offeror’s Technical Proposal Volume.

Section 3 – Technical Acceptability In Section 3, the Offer shall clearly demonstrate that it has a clear understanding of the requirements outlined in the SON and MECs. If the Offeror is an authorized distributor, a copy of its signed authorized distributor letter must be included with Volume I.

Section 4 – Past Performance In Section 4, the Offer shall provide past performance questionnaires (Exhibit A) to past performance references/points of contact for contracts of similar nature (size, scope and complexity) to be completed and returned to the…