Tab 04 SOW.pdf
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- Attached to
- analysis of Ophthalmic Images to quantify Spaceflight-Associated Neuro-ocular measures. .
- Solicitation number
- 80NSSC26938183Q
About this file
This is a Statement of Work for ocular data analysis services funded by the Human Research Program. The vendor shall analyze 25 Electroretinogram (ERG) datasets, 25 OCT-A (Ocular Coherence Tomography Angiography) datasets, and 3 OCT IVFA (intravenous fluorescein angiography) datasets. The vendor must possess experience in advanced ocular assessments using the specific vendor devices employed in this study.
The contractor's responsibilities include analyzing pERG data to assess retinal ganglion cell function across small and large check pattern protocols; analyzing and quantifying PhNR (photopic negative response) amplitudes from ERG data; assessing retinal vasculature and vascular leakage evidence in IVFA datasets while interpreting retinal blood barrier integrity; analyzing ocular vasculature at the macula and optic nerve head using OCT-A images; assessing density and axial distribution of retinal microvasculature; developing perfusion and vessel density maps; analyzing flow void size and area in retinal layers; comparing results to previously analyzed datasets for comprehensive interpretation; and completing analysis timely to support SANS milestones. The place of performance is University of California, San Diego in San Diego, California. The period of performance runs from August 1, 2026 through July 31, 2028, with one option year extending from August 1, 2028 through July 31, 2029. Deliverables are scheduled as follows: end of year 1—17 ERG datasets, 17 OCT-A datasets, and 3 IVFA datasets; end of year 2—5 ERG datasets and 5 OCT-A datasets; end of year 3—3 ERG datasets and 5 OCT-A datasets.
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| File | Type | Posted |
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| Tab 07 Capability Statement.pdf |
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Statement of Work
1. Objective/Requirements
The Human Research Program funded the project, “Investigating Structure and Function of the Eye.”
This study is collecting ocular data using advanced ophthalmic hardware. Electroretinogram (ERG) data was collected to assess global ganglion cell function. Ocular Coherence Tomography (OCT) intravenous fluorescein angiography (IVFA) data was collected to determine whether the retinal blood barrier is disrupted due to spaceflight. OCT-A was collected to assess the vasculature of the retina.
Vendor shall analyze 25 ERG datasets, 25 OCT-A datasets, and 3 OCT IVFA datasets. Vendor must have experience in advanced ocular assessments collected with the specific vendor devices used for this study.
2. Characteristics, Scope, Specs
The contractor shall perform the following duties:
ERG datasets o Analyze pERG (pattern ERG) data to assess retinal ganglion cell function. Analyze both small and large check pattern protocols.
o Analyze and quantify the amplitudes of the PhNR (photopic negative response) data obtained via ERG IVFA datasets o assess the retinal vasculature and evidence of vascular leakage over time o provide interpretation of the retinal blood barrier integrity
OCT-A datasets o Analyze the ocular vasculature of the retina at the macula and optic nerve head with
OCT-A images o Assess the density and axial distribution of the retinal microvasculature with OCT A images o Develop perfusion and vessel density maps o Analyze size and area of flow voids in retinal layers
Compare to other datasets previously analyzed to provide comprehensive final results and interpretation summary.
Complete analysis in a timely manner to support SANS milestones
3. Place of Performance
University of California, San Diego in San Diego, California
4. Period of Performance
Analysis shall be performed August 1, 2026-July 31, 2028 with 1 option year.
Period of Performance: 8/1/2026-7/31/2028
Option Year 1: 8/1/2028-7/31/2029
Deliverables
End of year 1: Complete analysis of 17 ERG data sets, 17 OCTA data sets, and 3 IVFA data sets.
End of year 2: Complete analysis 5 ERG data sets and 5 OCTA data sets.
End of year 3: Complete analysis of 3 ERG data sets and 5 OCTA data sets
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