SSN BN 75N91024SS6904112.pdf

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GENERAL INFORMATION/CLASSIFICATION

Title: Meso Scale Discovery MESO QuickPlex SQ 120MM Reader Notice Type: Sources Sought Solicitation Number: 75N91024SS6904112 Posted Date: 04/04/2024 Response Date: 04/11/2024 PSC Code: 6640 – Laboratory Equipment and Supplies NAICS Code: 334516 – Analytical Laboratory Instrument Manufacturing

ISSUED BY:

National Institutes of Health (NIH), National Cancer Institute (NCI), Office of Acquisitions (OA)

DESCRIPTION:

This is a Sources Sought Notice (SSN) and is for information and planning purposes only. This notice shall not be construed as a solicitation or as an obligation on the part of the National Cancer Institute (NCI). The purpose of this SSN is to identify qualified business concerns, especially small businesses, that are interested in and capable of performing the work described herein, The NCI does not intend to award a contract based on responses received nor otherwise pay for the preparation of any information submitted. Responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. The requirement’s suggested North American Industry Classification System (NAICS) code is 334516 – Analytical Laboratory Instrument Manufacturing with a size standard of 1000 Employees.

THERE IS NO SOLICITATION AVAILABLE AT THIS TIME. However, should such a requirement materialize, no basis for claims against NCI shall arise because of a response to this SSN or the NCI’s use of such information furnished in response to this notice.

RESPONSE INSTRUCTIONS:

Responses to this notice shall be submitted via email to the Contracting Officer, Miguel Diaz, at miguel.diaz@nih.gov no later than 12:00 P.M. EST on Thursday, April 11, 2024 (04/11/2024). All information furnished must be in writing and must contain enough detail to allow the NCI to determine the respondents’ ability to meet the requirements described herein. A response should not exceed 10 single-sided pages including all attachments, charts, etc. (single space, 12-point font minimum) that clearly responds to the below questions. All proprietary information should be marked as such. Please reference notice number 75N91024SS6904112 for all correspondence.

Requested Information: Please provide the following information in your company’s response:

1. Company Name

2. Point of Contact (POC) (including telephone and email address)

3. Company’s System for Award Management Unique Entity Identifier (UEI)

4. Socio-economic status (8(a), SDVOSB, VOSB, Woman-Owned, Other… etc.).

5. Information on any currently held government contracts to include:

a. Contract Number

b. Type of Contract

c. Contracting Agency (GSA, SEWP, etc.)

d. If you hold a current GSA schedule contract, specify which SINs are best suited for providing the services/items specified in the SOW.

6. Provide product information such as brochures, manuals, etc. to demonstrate that the proposed equipment is:

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a. equal to or greater than the minimum required features/characteristics listed in Section 4.0

SPECIAL ORDER REQUIREMENTS.

b. the brand name equipment listed in Section 5.0 BRAND NAME PRODUCTS.

7. Provide any available pricing information.

8. Provide information pertaining to the origin of the equipment, and where it’s manufactured.

This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use the information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s capability. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a synopsis and solicitation may be published. However, responses to this notice will not be considered an adequate response to a solicitation(s).

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1.0 TITLE

Meso Scale Discovery MESO QuickPlex SQ 120MM Reader for performing immunoassays.

2.0 BACKGROUND

The Laboratory of Molecular Biology (LMB) conducts both preclinical and clinical studies developing antibody-based agents, such as immunotoxins, for the treatment of cancer. This research often requires measuring the amounts of these antibody-based agents in the serum or plasma of experimental animals or patients who are receiving treatment in the NIH Clinical Center. One ongoing project in LMB is studying the molecular response of Hairy Cell Leukemia (HCL) and Hairy Cell Leukemia variant (HCLv) patients to the immunotoxin Moxetumomab pasudotox in order to understand mechanisms of treatment sensitivity and resistance. Resistance is often seen in conjunction with the development of antidrug antibodies (ADAs). Therefore, these studies require the measurements of both the immunotoxin drug and ADAs in patient blood.

Immunoassays are used to measure antibodies and antibody-based agents in various fluid samples, including serum and plasma. It is advantageous to use detection systems that are sensitive (able to detect very low levels of antibody), but it is also important that a wide range (from very low to very high) of antibody concentrations can be detected from the same sample.

Finally, it is useful to detect more than one type of antibody in the same sample, avoiding multiple separate assays (especially for precious/limited patient samples).

Electrochemiluminescence Detectors can fulfill each of these three functions.

2.1 BRAND NAME

The MESO QuickPlex SQ 120MM Reader is manufactured and sold solely by Meso Scale Discovery (MSD), a division of Meso Scale Diagnostics, LLC. of Rockville, MD. The instrument is compatible only with microwell plates and immunoassay kits sold by MSD and vice versa. MSD utilizes electrochemiluminescence to detect binding events on patterned arrays including protein drugs and antibodies. There are no other known technologies that enable multiplexed measurement using electrochemiluminescence for detection. There are no other known suppliers that provide an electrochemiluminescence detection system that is not reliant on beads or flow cells, which have a more restricted range of detection. The MSD platform is unique in its method for detection. MSD’s ECL detection utilizes proprietary SULFO-TAG™ labels that emit light upon electrochemical stimulation initiated at the electrode surfaces of MULTI-ARRAY® and MULTI-SPOT® microplates through biomolecular interactions between the analyte and labeled reporter at the surface.

2.2 OBJECTIVE

The MESO QuickPlex SQ 120MM Detector will be used for studying the molecular response of HCL and HCLv patient leukemic cells to Moxetumomab pasudotox treatment to understand mechanisms of treatment sensitivity and resistance. Resistance is often seen in conjunction with the development of antidrug antibodies (ADAs). Therefore, these studies require the measurements of both the immunotoxin drug and ADAs in patient blood. This instrument will also be used to measure the levels of antibody-based immunotoxin and ADAs in clinical samples from HCL and HCLv patients.

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3.0 TYPE OF ORDER

This shall be a firm fixed price purchase order.

4.0 SPECIAL ORDER REQUIREMENTS

4.1 PRODUCT FEATURES/SALIENT CHARACTERISTICS

NCI requires an instrument that can detect electrochemiluminescence, measures multiple antibodies over a wide concentration range, and is small enough to reside on a benchtop. The MESO QuickPlex SQ 120MM Detector has been identified to fulfill these requirements.

The following product features/characteristics are required for this requirement:

• Small footprint, allowing the instrument to fit on a benchtop (space available is 24”x24”)

• Cooled scientific-grade CCD camera and precision lens assembly.

• Able to detect up to 10 different antibodies in a sample using chemiluminescence.

• Exhibits a wide dynamic range (>105) to detect low and high antibody levels from the same sample.

• High sensitivity, with limits of detection as low as 0.05-1 pg/ml

• Rapid read times to increase efficiency.

• Compatible with Meso Scale Diagnostics 96-well plates and QuickPlex plates

• Includes laptop with simple, fast, secure data analysis software.

• Low maintenance: no fluidics to clog and no daily or monthly user maintenance required.

5.0 BRAND NAME PRODUCTS.

5.1 The following Brand Name products have been identified to fulfill these requirements:

Item Product Description Product No. Qty Amount

1 MESO QuickPlex SQ 120MM Reader AI1AA-0 1 2 Shipping n/a 1

Total:

5.2 DELIVERY

Delivery shall be within ninety (90) calendar days of the purchase order award. All shipping/handling (including FOB) and delivery/installation fees shall be included in the quote.

Upon delivery, the Contractor shall notify the respective NCI Technical Point of Contact (TPOC) to schedule installation dates and times. Installation shall occur within one (1) business day of delivery and shall be performed by, or under the direct supervision of, an Original Equipment Manufacturer (OEM) certified technician. Equipment shall be delivered to and installed at the following address:

Delivery will be to the following address:

National Cancer Institute, NIH Building 37, Room 5124 37 Convent Drive Bethesda, MD 20892

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6.0 INSPECTION AND ACCEPTANCE

Pursuant to FAR Clause 52.212-4, all items to be delivered in relation to this award are subject to final inspection and acceptance by an authorized representative of the Government. The authorized representative of the Government is the Technical Point of Contact (TPOC) who is responsible for inspection and acceptance of all services, materials, or supplies to be provided by the Contractor.

7.0 TECHNICAL POINT OF CONTACT

The Technical Point of Contact (TPOC) is responsible for inspection and acceptance of all work in relation to this requirement and will serve as the Governments primary point of contact throughout the duration of the requirement. All efforts must be coordinated with this individual.

Note: The TPOC has limited authority within the Statement of Work. They do not have the authority to commit or obligate Government funds or make changes to the terms and conditions of the purchase order. As such, any changes to the purchase order must be performed by a warranted Government Contracting Officer with appropriate delegated authority to do so.

The NCI Technical Point of Contact (TPOC) will be listed in any resulting purchase order.

9.0 PAYMENT

Payment shall be made after successful delivery, installation, training, and acceptance by the NCI Technical Point of Contact (TPOC).