SOW_Nanoparticle Tracking Analysis Services_Updated.docx

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AN12--Notice of Intent to Sole Source Nanoparticle Tracking Analysis Services
Solicitation number
36C26125Q0748
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This Statement of Work (SOW) details nanoparticle tracking analysis services for the San Francisco VA Medical Center's long COVID research. The project requires analyzing 291 extracellular vesicle samples using a ZetaView x30 system to identify blood biomarkers that differentiate Veterans who have recovered from COVID versus those experiencing long-term effects. Specific analysis requirements include measuring particles between 10-1000 nm, determining particle size distribution, calculating mean/median/mode size, and reporting concentration in particles/mL, with fluorescence detection capability mandatory.

The VA intends to sole source this contract to Alpha Nano Tech, LLC in Chapel Hill, NC under FAR Part 13 Simplified Acquisition Procedures. The procurement falls under NAICS code 541380 (Testing Laboratories and Services) with a small business size standard of $19.0 million. The contract will be for Health R&D Services: Applied Research, and all work must comply with VA Central Institutional Review Board (IRB) and HIPAA data handling protocols. Delivery will be to the San Francisco VAMC, with point of contact Paul Betancourt, SRA III.

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Statement of Work (SOW)

San Francisco VA Medical Center 4150 Clement St.

San Francisco, CA 94121

Nanoparticle Tracking Analysis (NTA) for Long COVID Research

1. Background The San Francisco VA Medical Center (SFVAMC) Research Laboratory requires nanoparticle tracking analysis of extracellular vesicle (EVs) samples to identify blood biomarkers differentiating Veterans who have recovered from COVID from those with long-lasting effects like “brain fog.”

2. Project Scope The contractor shall provide scatter mode nanoparticle tracking analysis on 291 Government-furnished samples for long COVID using nanoparticle tracking analysis instrumentation capable of measuring particles between 10-1000 nm, to determine the size and quantity of EVs.

3. Specifications Contractor shall use a ZetaView x30 system. Analysis must include particle size distribution, mean/median/mode size, and concentration in particles/mL. Fluorescence detection capability is required.

4. Delivery Location:

San Francisco VAMC 4150 Clement Street San Francisco, CA 94121

ATTN: Paul Betancourt, SRA III, paul.betancourt@va.gov, (415) 221-4810 ext. 23946

5. Delivery Requirements:

Contractor shall comply with all VA Central Institutional Review Board (IRB) and HIPAA data handling protocols.

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