SOW.docx
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- Laboratory items
- Solicitation number
- BAC260011_1301375341
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This is a Statement of Work (SOW) for research support services to be provided to the Bacteriology Department of the U.S. Naval Medical and Research Unit SOUTH. The primary objective is to conduct spatial analysis of epidemiological data from enteric diseases and support surveillance activities focused on infectious diarrhea, which represents a significant threat to deployed military forces worldwide. The U.S. military has prioritized vaccine development against common enteropathogens associated with travelers' diarrhea, including ETEC, Campylobacter, and Shigella species. Prior to clinical vaccine trials, the work requires improved understanding of disease incidence, prevalence, and clinical spectrum characterization relative to etiology.
The SOW specifies that multiple laboratory reagents and supplies are required to operate instruments including Phoenix and MALDI Biotyper systems. The work will involve studying epidemiology and burden of gastrointestinal illness and associated enteropathogens in a traveler population in Cusco, Peru, who will serve as suitable surrogates for deployed U.S. military personnel in diarrhea-endemic regions. Additionally, the effort includes monitoring etiology and population dynamics of respiratory illness among the same traveler population. The related Special Notice solicitation (BAC260011_1301375341) lists specific laboratory items required, including bacteriological media, diagnostic supplies, PCR reagents, culture swabs, DNA extraction kits, and analytical equipment such as the Mx3000P Strip Tubes and screening tape components. The contracting agency is the Department of the Navy Naval Supply Systems Command.
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STATEMENT OF WORK
The Bacteriology Department of the U.S. Naval Medical and Research Unit SOUTH conducts spatial analysis of epidemiological data from enteric diseases for surveillance activities.
Infectious diarrhea remains a major threat to deployed military forces worldwide, in addition to their impact on travelers and populations (predominantly children) living in the developing world. Despite advances in our understanding of the incidence, prevalence, and biology of infectious diarrhea, obstacles remain to the development of effective countermeasures. Due to the mission-aborting potential of diarrhea disease, the U.S. military has placed a high priority on the development of an effective vaccine against the most common enteropathogens associated with travelers’ diarrhea like ETEC, Campylobacter and Shigella species. However, prior to any vaccine clinical trial, a better understanding of the true incidence of disease and better characterization of the true clinical spectrum of disease in respect to etiology should occur.
Multiple reagents and other supplies are needed to run tests in different instruments such as Phoenix, Maldi Biotyper to understand the epidemiology and burden of gastrointestinal illness and associated enteropathogens in a traveler’s population in Cusco, Peru who will serve as suitable surrogates for deployed United States military personnel as related to the acquisition of infectious diarrhea and prevention thereof in diarrhea endemic regions and monitor etiology and population dynamics of respiratory illness among a traveler population in Cusco, Peru
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