Sources Sought Notice_antibodies FINAL.pdf

SOURCES SOUGHT NOTICE

1. Solicitation Number: 75N95020Q00192

2. Title: KDEL receptor antibodies

3. Classification Code: 6640

4. NAICS Code: 334516 - Analytical Laboratory Instrument Manufacturing

Dollars or Number of Employees: 1,000

5. Description:

This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice.

This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only.

Background:

The mission of the National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) is to conduct state-of-the-art research on basic mechanisms that underlie drug abuse and addiction and to develop new methods for the treatment of drug abuse and addiction. Research is supported at the molecular, genetic, cellular, animal, and clinical levels and is conceptually integrated, highly innovative, and focused on major problems in the field. The long-term goal of the research is to better understand the biological and behavioral factors contributing to initiation, maintenance, and elimination of drug abuse and addiction (and associated diseases), and to translate this knowledge into improved strategies for preventing, treating, and reducing the negative consequences for the individual and for society caused by drug abuse and addiction.

The Molecular Mechanisms of Cellular Stress and Inflammation (MMCIS) at the NIDA IRP was established for the purpose of studying the molecular mechanisms of cellular stress and inflammation that are caused by drugs of abuse. Part of these efforts is to study the endoplasmic reticulum (ER) exodosis. KDEL receptors (KDELRs) play an important part of ER exodosis. In order to study the KDELRs during ER stress and exodosis, antibodies are required to analyze the native receptors during normal, controlled or experimental conditions. The current KDELR antibodies on the market are not specific for each specific serotype nor are they specific to the KDELRs themselves.

Requirement:

MMCIS requires a company to produce monoclonal and polyclonal KDEL receptor (KDELR) antibodies for each of the subtypes of KDELR (KDELR1, KDELR2, KDELR3) separately.

Salient characteristics:

• Polyclonal antibody specific to KDEL receptor 1

• Polyclonal antibody specific to KDEL receptor 2

• Polyclonal antibody specific to KDEL receptor 3

• Monoclonal antibody and hybridoma specific to KDEL receptor 1

• Monoclonal antibody and hybridoma specific to KDEL receptor 2

Quantity: 1 of each type of KDEL receptor antibody listed above

Anticipated Delivery Date:

20-22 weeks after date of award

Capability Statement / Information Sought:

Respondents must provide clear and convincing documentation of their capability of providing the services specified in this notice. Also, information must be provided in sufficient details of the respondents’ (a) staff expertise, including their availability, experience, formal and other training; (b) current in-house capability to perform the work; (c) provide examples of prior completed projects of similar nature (i.e. Government contracts, references, and other related information); and (d) corporate experience and other management capability.

The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc.), pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements.

Finally, respondents are also encouraged to provide a general overview of the respondent’s opinions about the difficulty and/or feasibility of the potential requirement, and any other information regarding innovative ideas or concepts that may be applicable.

Submission Instructions:

All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer Identified below. The response must be received on or before August 7, 2020 at 2:00 p.m. EST.

Facsimile responses are NOT accepted.

One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing.

The information submitted must be in an outline format that addresses each of the elements of the requirement and in the capability statement/information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required.

The response is limited to ten (10) pages. The 10-page limit does not include the cover page, executive summary, or references, if requested.

The response must include the respondents’ technical and administrative points of contact (including names, titles, addresses, telephone and fax numbers, and e-mail addresses) and DUNS number.

Disclaimer and Important Notes:

This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted.

After a review of the responses received, a combined synopsis solicitation may be published in beta.sam.gov. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality:

No proprietary, classified, confidential, or sensitive information should be included in your response.

The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).”

Primary Point of Contact:

Erin Dwyer, Contract Specialist Erin.dwyer@nih.gov Phone: (301) 402-8657

Secondary Point of Contact:

Kenneth E. Goodling, Contracting Officer Kenneth.goodling@nih.gov Phone: (301) 827-5854