Sources_Sought_75N94024R00003_1.pdf

Small Business Sources Sought Notice RFP No. 75N94024R00003

Sam.Gov Notice Type: Small Business Sources Sought Notice w/ SOW Notice Number: 75N94024R00003 Title of Requirement: Preclinical Medications Screening in Dependence Models of Alcohol

Use Disorder

Introduction

This notice is issued on behalf of The National Institute on Alcohol Abuse and Alcoholism (NIAAA) by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Office of Acquisitions, Acquisition Resources Branch, NIH, DHHS, UNITED STATES. It is a Small Business Sources Sought (SBSS) notice. This notice is not a request for proposals and does not commit the Government to award a contract now or in the future. No solicitation is available at this time. The purpose of this notice is to obtain information regarding: (1) the availability and capability of all qualified small business sources; (2) whether they are small businesses; HUBZone Small Businesses;

Service-disabled, Veteran owned Small Businesses; 8(a) Small Businesses; Veteran-owned Small Businesses; Woman-owned Small Businesses; or Small Disadvantaged Businesses; and (3) Their size classification according to the North American Industry Classification System, (NAICS) Code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible or through full and open competition. The Government shall not assume any costs for preparing or submitting any information in response to this notice or for the Government’s use of the information. Small business organizations must have their size status is certified by the U.S. Small Business Administration (SBA). The NAICS code is 541715, Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) with a size standard of 1000 employees.

Description

NIAAA currently supports a preclinical medication efficacy testing program to foster discovery of medication targets and lead compounds. The program is supported by three contracts. The first, Contract No. 75N94019C00008, is with the Medical University of South Carolina (MUSC) and expires in mid-August 2024. It is being recompeted for a follow-on contract to continue the project and meet the current and anticipated future needs under NIAAA’s Medication Development Program in the Medical Development Medications Development Branch, Division of Treatment and Recovery Research, NIAAA. The second, Contract No. 75N94019C00009, is with the Indiana University to support test medications in alcohol preferring rat strains (tests medications in alcohol preferring P and HAD1 rats selectively bred for alcohol preference and expires in September 2024. A third, Contract No. 75N94023C00014, with the Louisiana State University Health Sciences Center (LSUHSC) for blind medication testing on alcohol drinking, and negative affect and pain measures in the chronic intermittent ethanol (CIE) exposure model in rats to allow for direct comparison of drug effects in mice and rats using the same model under the other two ongoing contracts mentioned above and awarded as a Base contract with options through September 2028.

This notice is for a contract to continue the requirement for the blind testing of compounds on excessive alcohol drinking in mice using models of alcohol dependence.

It will use mechanisms having intellectual property conditions favorable to compound providers when acquiring compounds from industry to eliminate a major barrier to testing optimized compounds having preclinical as well as clinical toxicology data and stimulate

Small Business Sources Sought Notice RFP No. 75N94024R00003 interest by the pharmaceutical industry in developing high quality marketable compounds for Alcohol Use Disorder. The work is for severable services to support testing capacity of up to four (4) compounds per year over the next five years. It is anticipated that a 12-month base contract with four (4) 12-month option periods through August 14, 2029, will be awarded.

The NIAAA is seeking capability statements from interested and qualified Small Business potential sources for this project entitled, Preclinical Medications Screening in Dependence Models of Alcohol Use Disorder. Capability statements submitted in response to this announcement should demonstrate the offeror’s qualifications, specifically their capability to:

To assess compounds effects in standardized models of elevated alcohol intake in mice exposed to chronic intermittent ethanol.

To assess compound effects on negative affect and pain measures in alcohol dependent mice.

To collect, analyze, and display test data and report them to designated NIAAA personnel.

Capability Statements will be assessed on the above and any other specific and pertinent information that may enhance the Government’s assessment of the respondent’s capabilities.

Interested organizations that believe they possess the capabilities necessary to undertake this project, should submit a Capability Statement thoroughly addressing the areas above and specified in the Statement of Work, attached. Responses to the Sources Sought Notice shall be provided via e-mail as a portable data file (PDF), to the Point of Contact named herein.

Responses must reference the sources sought notice number 75N94024R00003. Limit responses to 10 single-sided pages or less. Any proprietary information should be so marked.

Submissions must be received no later than March 7, 2024 at 1:00 pm, Eastern Time

(ET).

Capability Statements must identify the business status of the organization (i.e., educational, institution, non-profit, large business, small business, 8 (a), or other corporate or non-corporate entity). Also include the name and telephone number of a point of contact having knowledge of the submitted information.

Capability Statements that do not provide sufficient information or are submitted after the date and time above will not be considered. Collect calls will not be accepted.

Point of Contact

Lisa L. Schaupp, Supervisory Contracting Officer, NICHD Office of Acquisitions, Acquisition Resources Branch, NIAAA, Phone: 301-827-8135, lisa.schaupp@nih.gov.