WOMEN-OWNED SMALL

BUSINESS (WOSB)

SOLICITATION/CONTRACT/ORDER FOR COMMERCIAL PRODUCTS AND COMMERCIAL SERVICES

1. REQUISITION NUMBER PAGE 1 OF

2. CONTRACT NUMBER 3. AWARD/EFFECTIVE

DATE

4. ORDER NUMBER 5. SOLICITATION NUMBER 6. SOLICITATION ISSUE

DATE

7. FOR SOLICITATION

INFORMATION CALL:

a. NAME b. TELEPHONE NUMBER (No collect calls)

8. OFFER DUE DATE/

LOCAL TIME

9. ISSUED BY

13b. RATING

14. METHOD OF SOLICITATION

CODE

15. DELIVER TO 16. ADMINISTERED BY CODE

18a. PAYMENT WILL BE MADE BY CODE17a. CONTRACTOR/

OFFEROR

CODE

FACILITY

CODE

CODE

TELEPHONE NUMBER

17b. CHECK IF REMITTANCE IS DIFFERENT AND PUT SUCH ADDRESS IN

OFFER

18b. SUBMIT INVOICES TO ADDRESS SHOWN IN BLOCK 18a UNLESS BLOCK

BELOW IS CHECKED

REQUEST

FOR QUOTE

(RFQ)

INVITATION

FOR BID

(IFB)

REQUEST

FOR

PROPOSAL

(RFP)

SEE ADDENDUM

19.

ITEM NUMBER

20.

SCHEDULE OF SUPPLIES/SERVICES

21.

QUANTITY

22.

UNIT

23.

UNIT PRICE

24.

AMOUNT

(Use Reverse and/or Attach Additional Sheets as Necessary)

25. ACCOUNTING AND APPROPRIATION DATA 26. TOTAL AWARD AMOUNT (For Government Use Only)

28. CONTRACTOR IS REQUIRED TO SIGN THIS DOCUMENT AND RETURN

COPIES TO ISSUING OFFICE. CONTRACTOR AGREES TO FURNISH

AND DELIVER ALL ITEMS SET FORTH OR OTHERWISE IDENTIFIED ABOVE AND

ON ANY ADDITIONAL SHEETS SUBJECT TO THE TERMS AND CONDITIONS

SPECIFIED

29. AWARD OF CONTRACT: REFERENCE OFFER

DATED . . YOUR OFFER ON SOLICITATION

(BLOCK 5), INCLUDING ANY ADDITIONS OR CHANGES WHICH ARE

SET FORTH HEREIN, IS ACCEPTED AS TO ITEMS:

30a. SIGNATURE OF OFFEROR/CONTRACTOR

30b. NAME AND TITLE OF SIGNER (Type or print) 30c. DATE SIGNED

31a. UNITED STATES OF AMERICA (SIGNATURE OF CONTRACTING OFFICER)

31b. NAME OF CONTRACTING OFFICER (Type or print) 31c. DATE SIGNED

AUTHORIZED FOR LOCAL REPRODUCTION

PREVIOUS EDITION IS NOT USABLE

STANDARD FORM 1449 (REV. 11/2021)

Prescribed by GSA - FAR (48 CFR) 53.212

10. THIS ACQUISITION IS UNRESTRICTED OR

NORTH AMERICAN

INDUSTRY CLASSIFICATION

STANDARD (NAICS):

SIZE STANDARD:

13a. THIS CONTRACT IS A

RATED ORDER UNDER

THE DEFENSE PRIORITIES

AND ALLOCATIONS

SYSTEM - DPAS (15 CFR 700)

SET ASIDE: % FOR:

11. DELIVERY FOR FREE ON

BOARD (FOB) DESTINATION

UNLESS BLOCK IS MARKED

SEE SCHEDULE

12. DISCOUNT TERMS

ARE ARE NOT ATTACHED

ARE ARE NOT ATTACHED

27a. SOLICITATION INCORPORATES BY REFERENCE (FEDERAL ACQUISITION REGULATION) FAR 52.212-1, 52.212-4. FAR 52.212-3

AND 52.212-5 ARE ATTACHED. ADDENDA

27b. CONTRACT/PURCHASE ORDER INCORPORATES BY REFERENCE FAR 52.212-4. FAR 52.212-5 IS ATTACHED. ADDENDA

8(A)

ECONOMICALLY

DISADVANTAGED

WOMEN-OWNED SMALL

BUSINESS (EDWOSB)

SERVICE-DISABLED

VETERAN-OWNED

SMALL BUSINESS

(SDVOSB)

HUBZONE SMALL

BUSINESS

SMALL BUSINESS

NOTE: OFFEROR TO COMPLETE BLOCKS 12, 17, 23, 24, AND 30.

Section A - Solicitation/Contract Form

Next Generation Sequencing (NGS) 2026

N0018926QB097

Section B - Supplies or Services & Prices or Costs

Additional Information/Notes

The Government intends to unilaterally deobilgate any unliquidated obligations 90 days after each period of performance. Prior to doing so, the Contracting Officer (or Administrative Contracting Officer) will notify the contractor of the intended amount of deobligation and ask the contractor to confirm within one week that all invoices for the completed period of performance have been submitted and processed for payment (with the exception of any invoice for rate adjustment upon receipt of DCAA approved final rates for any cost-type CLINs or SLINs). Upon confirmation that all invoices have been submitted and processed for payment, or upon the contractor's failure to respond to the PCO/ACOs notification of intent to deobligate, the Contracting Officer or Administrative Contracting Officer will unilaterally deobligate the potential ULOs by reducing the funded amount to an amount equal to the contractors invoiced/paid amount for that contract period of performance.

Note: Reduction of cost-reimbursement CLINs or SLINs in accordance with the above DOES NOT change either party's obligations under a Final Invoice submitted upon DCMA establishing final rates for each CLIN and or SLIN.

Item Supplies/Service Quantity Unit Unit Price Amount

FY26 PathoSeq Bio - P0103 (Labor - Wet-lab Seq Specialist and Bioinformatics Specialist)

Pricing Arrangement: Firm Fixed Price

12 Months

0002 FY26 PathoSeq Bio - DBPAO (Materials/Services/ODCs)

Pricing Arrangement: Cost No Fee

1 Lot

0003 Travel

Pricing Arrangement: Cost No Fee

1 Lot

Section C - Description/Specifications/Statement of Work

Performance Work Statement (PWS) for

Genomic Differentiation of Bacterial and/or Viral Diseases

1.0 General Information

1.1 Introduction

The U.S. Naval Medical Research Unit NAMRU) INDO PACIFIC aims to monitor and characterize emerging and re-emerging infectious ( diseases of importance to warfighter health and to develop mitigation strategies against threats to warfighter health and medical readiness in the Indo-Pacific region.

1.2 Objectives

The objectives of this contract are to obtain services to (i) improve standardized laboratory procedures to detect biothreat agents, arboviruses, and antibiotic resistant organisms from contrived, environmental, zoonotic or patient samples, (ii) develop detailed consensus genomes for an expanded subset of regional pathogens of concern, and (iii) provide bioinformatic platform to identify novel emerging and re-emerging infectious diseases in the region in samples collected as part of the NAMRU INDO PACIFIC Biosurveillance program.

1.3 of Work Scope

The Contractor shall provide all personnel, materials, facilities, licenses, and other supplies and nonpersonal services including local agreements and assist with research approvals necessary to conduct research services as defined in this PWS. This is a non-personal ethical services award for non-severable services.

1.4. Background

NAMRU INDO PACIFIC has implemented an Armed Forces Health Surveillance Division's Global Emerging Infections Surveillance (GEIS) program to monitor and address emerging and re-emerging pathogens in the Indo-Pacific region. This program establishes robust surveillance networks to detect and characterize novel pathogens. Through collaboration with host-nation partners, NAMRU INDO PACIFIC collects human and animal samples containing pathogens of interest for analysis using Next Generation Sequencing (NGS).

Advanced sequencing bioinformatics is then employed to analyze and interpret the raw data, providing critical insights into pathogen genomics and epidemiology.

To date, NAMRU INDO PACIFIC's collaborators supporting the surveillance networks include, but are not limited to the following:

1. Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit laboratory, Vientiane, Laos

2. Institut Pasteur Vientiane, Laos du Laos,

3. Tropical Diseases Research & Education Centre at the University Malaysia, Kuala Lumpur, Malaysia Infectious

4. Monash University, Selangor, Malaysia

5. National Defence University of Malaysia, Kuala Lumpur, Malaysia

6. University of Malaysia Sabah, Sabah, Malaysia

7. The Malaysian Armed Forces sites in Malaysia

8. Institute of Malariology, Parasitology and Entomology Quy Nhon, Hanoi, Vietnam

9. Vietnam Institute of Animal and Veterinary Science, Vietnam

10. Various locations in and around Metro Manila, Philippines

11. Hanyang University, Seoul, South Korea.

12. The National Defense Medical Center and other Taiwanese military locations in Taiwan

13. Central Public Health Laboratory, Port Moresby, Papua New Guinea

14. University of Florida, Gainesville, USA

1.5 Applicable Protocol(s), Standard Operating Procedures (SOPs), Publication(s)

1.5.1 IRB HRPO.NAMRUIP.2025.0003 protocol titled, "Genomic Differentiation of Bacterial versus Viral Diseases Across Asia and Oceania" and HRPO.NAMRUIP.2024.0005 protocol titled, "Phylogenetic Analysis of Korean Severe Fever and Thrombocytopenia Syndrome Virus Samples since 2013".

1.5.2 Other protocols may be added when deemed necessary and appropriate by NAMRU INDO PACIFIC Project Officer (PO).

Deliverable Frequency # of Copies

Medium/Format Submit To

Kickoff meeting Once within two weeks of task order award (TOA)

Verbal communication in English.

Minutes in English

NAMRU

INDO

PACIFIC PO

& COR

Protocol approval final study and version as approved by protocol the country/local IRB.

Once upon approval.

One Word document, written in English PO and COR

Teleconference Progress Reports Quarterly One

Verbal communication via teleconferencing; Meeting minutes to be provided in Word document in English

PO and COR

Sequencing reports, Fasta files, and other related information requested

Quarterly One Word document, written in English PO and COR

Trip Reports Within seven days of returning from the trip

One Word document, written in English PO and COR

R1 Report Within 6 months and 10 days of

TOA

One Word document, written in English PO and COR

Final Report At the end of the period of performance (PoP).

One Word document, written in English PO and COR

REQUIREMENTS4. PERFORMANCE SUMMARY

P W S Paragraph

Performance Standard and AQL

Quality Assurance Method

Acceptance

2.3.2 Obtain Local and regulatory approvals or approval modifications to include IRB and /or IACUC protocol clearance.

Monitoring by

NAMRU INDO

PACIFIC PO and

COR

Receipt of approved IRB protocol and any other required local and regulatory approvals. 0% variance.

2.3.3 Obtain HRPP and CLAR approvals.

Monitoring by PO and COR

Receipt of HRPP and CLAR approvals.

0% variance.

2.3.5.3 Provide on-site training to laboratory staff at NAMRU INDO PACIFIC's collaborating sites (at three sites).

Monitoring by PO and COR

0% variance. Both positive and negative performance shall be documented.

2.3.5.5 Complete next generation sequencing of 90 samples.

Monitoring by PO and COR

Deviation of 3 samples (i.e. must sequence 87 samples). Both positive and negative performance shall be documented.

2.3.5.8

Provide Sequencing reports, Fasta files and any other related information requested by NAMRU INDO PACIFIC

PO

Monitoring by PO and COR

Within 5 days of due date. Both positive and negative performance shall be documented.

2.3.5.10 Mid-year and final reports.

Monitoring by PO and COR

Within 5 days of due date. Both positive and negative performance shall be documented.

a) Definitions. As used in this clause--

1) Assurance of compliance means a written assurance that an institution will comply with requirements of 32 CFR Part 219, as well as the terms of the assurance, which the Human Research Protection Official determines to be appropriate for the research supported by the Department of Defense (DoD) component (32 CFR 219.103).

2) Human Research Protection Official (HRPO) means the individual designated by the head of the applicable DoD component and identified in the component's Human Research Protection Management Plan as the official who is responsible for the oversight and execution of the requirements of this clause, although some DoD components may use a different title for this position.

3) Human subject means a living individual about whom an investigator (whether professional or student) conducting research obtains data through intervention or interaction with the individual, or identifiable private information (32 CFR 219.102(f)). For example, this could include the use of human organs, tissue, and body fluids from individually identifiable living human subjects as well as graphic, written, or recorded information derived from individually identifiable living human subjects.

4) Institution means any public or private entity or agency (32 CFR 219.102(b)).

5) Institutional Review Board (IRB) means a board established for the purposes expressed in 32 CFR Part 219 (32 CFR 219.102(g)).

6) IRB approval means the determination of the IRB that the research has been reviewed and may be conducted at an institution within the constraints set forth by the IRB and by other institutional and Federal requirements (32 CFR 219.102 (h)).

7) Research means a systematic investigation, including research, development, testing, and evaluation, designed to develop or contribute to generalizable knowledge. Activities that meet this definition constitute research for purposes of 32 CFR Part 219, whether they are conducted or supported under a program that is considered research for other purposes.

For example, some demonstration and service programs may include research activities (32 CFR 219.102(d)).

b) The Contractor shall oversee the execution of the research to ensure compliance with this clause. The Contractor shall comply fully with 32 CFR Part 219 and DoD Directive 3216.02, applicable DoD component policies, 10 U.S.C. 980, and, when applicable, Food and Drug Administration policies and regulations.

c) The Contractor shall not commence performance of research involving human subjects that is covered under 32 CFR Part 219 or that meets exemption criteria under 32 CFR 219.101(b), or expend funding on such effort, until and unless the conditions of either the following paragraph (c)(1) or (c)(2) have been met:

1) The Contractor furnishes to the HRPO, with a copy to the Contracting Officer, an assurance of compliance and IRB approval and receives notification from the Contracting Officer that the HRPO has approved the assurance as appropriate for the research under the Statement of Work and that the HRPO has reviewed the protocol and accepted the IRB approval for compliance with the DoD component policies. The Contractor may furnish evidence of an existing assurance of compliance for acceptance by the HRPO, if an appropriate assurance has been approved in connection with previous research. The Contractor shall notify the Contracting Officer immediately of any suspensions or terminations of the assurance.

2) The Contractor furnishes to the HRPO, with a copy to the Contracting Officer, a determination that the human research proposed meets exemption criteria in 32 CFR 219.101(b) and receives written notification from the Contracting Officer that the exemption is determined acceptable. The determination shall include citation of the exemption category under 32 CFR 219.101(b) and a rationale statement. In the event of a disagreement regarding the Contractor's furnished exemption determination, the HRPO retains final judgment on what research activities or classes of research are covered or are exempt under the contract.

d) DoD staff, consultants, and advisory groups may independently review and inspect the Contractor's research and research procedures involving human subjects and based on such findings, DoD may prohibit research that presents unacceptable hazards or otherwise fails to comply with DoD procedures.

e) Failure of the Contractor to comply with the requirements of this clause will result in the issuance of a stop-work order under Federal Acquisition Regulation clause 52.242-15 to immediately suspend, in whole or in part, work and further payment under this contract, or will result in other issuance of suspension of work and further payment for as long as determined necessary at the discretion of the Contracting Officer.

f) The Contractor shall include the substance of this clause, including this paragraph (f), in all subcontracts that may include research involving human subjects in accordance with 32 CFR Part 219, DoD Directive 3216.02, and 10 U.S.C.

980, including research that meets exemption criteria under 32 CFR 219.101(b). This clause does not apply to subcontracts that involve only the use of cadaver materials.

(End of clause)

2.0 Requirements

2.1 The contractor bears primary responsibility for the research.

2.2. All correspondence, deliverables, and conversations with representatives of the U.S. Government will be in proficient English.

2.3 The Contractor shall implement the study protocol(s) (1.5 above) and monitor that implementation follows approved protocol. The study protocol to be used shall be confirmed by NAMRU INDO PACIFIC PO. For any deviations that occur from approved protocol, the Contractor shall report deviation to PO and the Contracting Officer's Representative (COR) within two business days. The Contractor shall

2.3.1 Provide managerial, supervisory, administrative and logistical support to execute the protocol. In addition, the Contractor shall provide the necessary personnel, materials, equipment, consumables, facilities, licenses - and all other direct and indirect costs associated with this project.

2.3.2 Assist NAMRU INDO PACIFIC to obtain regulatory and ethical approval from local internal institutional review board (IRB) at the selected study sites/locations where work is to be performed and any other required local approvals. Approvals must be obtained in writing.

2.3.3 Assist NAMRU INDO PACIFIC PO in obtaining Department of the Navy IRB approvals and Human Research Protections Program (HRPP) reviews and Command Level Administrative review (CLAR) by providing local partner human use and non-human study ethical approvals and any changes and amendments to the study protocols and study related documents for U.S. Government review as directed by the NAMRU INDO PACIFIC PO and/or the head of the NAMRU INDO PACIFIC HRPP. No samples shall be sequenced and/or data analyzed until after IRB, HRPP, and CLAR approvals and all other required approvals have been received in writing.

2.3.4 Work with local partners at each site to optimize Standard Operating Procedures (SOPs) improving detection efficiencies from samples collected for sequencing where needed for activities such as: collecting samples, transporting samples to laboratories for testing, reporting sequencing results, and storing bioinformatic data. This shall include designing and implementing all required training for local personnel.

2.3.5 Upon notification and receipt of the HRPP approval, and CLAR approval if applicable, for the research protocol from the NAMRU INDO PACIFIC PO, complete the following research activities:

2.3.5.1 Oversee the training of staff to don/doff of personal protective equipment (PPE) properly in the laboratory, perform sample-library preparation for sequencing, process serum/whole blood samples according to good clinical practices (GCPs), and onboard new SOPs as needed.

2.3.5.2 Handle all samples according to study protocol(s) in coordination with instructions for each protocol, ensuring local safety requirements and established standard laboratory operating procedures are adhered to.

2.3.5.3 Provide on-site training to laboratory staff at NAMRU INDO PACIFIC's collaborating sites (up to three sites), to

(1) implement sequencing methodologies via a contamination prevention and control strategy to include genetic barcoding procedures with GCPs and quality control procedures, (2) conduct custom hybridization-enrichment, amplicon-based, and metagenomics MinION and/or Illumina-based sequencing on site, as appropriate for the site, (3) and analyze genomics data from sequencing by bioinformatics that can identify, classify and define known and new mutations in known pathogens or characterize near- neighbor novel emerging pathogens, to include protocols for the identification of viral, parasitic, and/or bacterial targets. Where prior training on sites has occurred, conduct refresher training and quality control (QC) & quality assurance (QA).

2.3.5.4 Provide and/or upgrade an integrated system for concurrent molecular sequencing of both bacterial and/or viral diseases at each laboratory to include (1) modified molecular sequencing workflow SOPs tailored for each site's specific laboratory setup as needed, (2) sample processing and extraction equipment of nucleic acids from human, animal, and vector respiratory and blood/serum or other biological samples as needed, (3) hybridization-enrichment and amplicon-based MinION and/or Illumina sequencing equipment and supplies, and (4) bioinformatics software and hardware. The hybridization-enrichment sequencing methodology shall contain pathogen-specific enrichment probes customized for the pathogens known or suspected to be endemic at each of the study sites, as determined in collaboration with the NAMRU INDO PACIFIC and local laboratory partners. Any equipment acquired and invoiced as cost reimbursable items by the Contractor shall be U.S.

Government (USG) property and shall be returned to USG at the end of the contract. Equipment acquired shall be installed, serviced and maintained per manufacturer's guidelines. The Contractor shall provide documentation to PO and COR for the shipping, delivery, and receipt for equipment within 24-hours of delivery to the partner site(s). The Contractor shall provide reports for professional installation, service, and maintenance of the equipment.

2.3.5.5 Complete NGS of at least 100 samples to characterize SARS-CoV-2, Influenza A/B, Respiratory Syncytial Virus (RSV), Dengue Virus, Plasmodium species, Adenovirus, novel human Coronaviruses, other febrile diseases, and antibiotic resistant or biothreat pathogens. In addition, these results will assist in developing quality-controlled genomes of pathogens and identifying variants and sequence polymorphisms. Sample selection for testing shall be agreed upon with NAMRU INDO PACIFIC PO and local laboratory partners.

2.3.5.6 Ensure that NAMRU INDO PACIFIC COR and PO are informed during quarterly meetings if any specific project goals cannot be achieved or if any problems are encountered to completing tasks in this PWS.

2.3.5.7 Ensure that all data records are maintained and shared with NAMRU INDO PACIFIC PO and only among collaborating institutions. The data must be approved for presentation or publication by the NAMRU INDO PACIFIC Public Affairs Officer (PAO) including NAMRU INDO PACIFIC internal approvals. All electronic records shall be stored in secure computerized system that contains layered passwords for protection and hard copy documents in a locked and secured room.

2.3.5.8 Provide sequencing reports, Fasta files, and any other related information requested by NAMRU INDO PACIFIC PO on a quarterly basis.

2.3.5.9 Provide trip reports documenting tasks performed and subsequent sequencing results.

2.3.5.10 Provide a mid-year technical report and a final technical report.

3.0 Place of Performance

The work to be performed under this contract shall be in the United States. The locations for the sequencing and bioinformatic work shall be selected by mutual agreement between the Contractor and NAMRU INDO PACIFIC.

Potential sites for wet-lab sequencing training/sample processing include but are not limited to those mention in Section 1.4 above. Dry-lab analyses could occur on-site and/or remotely from the USA.

4.0 Deliverables

4.1 Kickoff meeting; The Contractor shall host a kickoff meeting no later than two weeks after task order award to present research and management plans, timeline for performance of tasks, introduce key and supporting personnel, and identify any coordination and potential risks for the performance of the tasks.

4.2 All study protocols, initial and any subsequent versions, as approved by the country/local IRB.

4.3 Quarterly Teleconference : The ontractor shall arrange and provide progress Meeting and Minutes C monthly meetings updates on all aspects of the Contractors' progress towards completing the tasks. The contractor shall generate and deliver a summary (e.g., meeting minutes) of the information shared at each teleconference meeting.

4.4 Sequencing reports, Fasta files, and other related information requested by PO; The ontractor shall provide C sequencing on a quarterly basis.reports, Fasta files, and other related information requested

4.5 Trip reports: The Contractor shall submit trip reports to detail tasks performed during the trip. Details shall include the site visited, the personnel in attendance, any trainings that were conducted, and tasks performed during the trip.

4.6 Technical Progress Reports: The ontractor shall (1) written mid-year report, due by the 10th working day C deliver one after the end of six (6) months, and one (1) written final annual report due at the end of the period of performance. Each written report shall contain:

4.6.1 A that includes the contract/task order, " title: "[ ]", and report number (e.g., R1, July - cover page contract number", title Dec 2026).

4.6.2 Report to detailed description of number of events supported and contract achievements (e.g., sequencing and/or provide bioinformatic tasks performed, etc.), any problems identified related to the execution of the project, and any training conducted other pertinent data beneficial for interpretation of the data or successful execution of the project.

4.6.3 Reports shall be cumulative- meaning the report will include information. All reports are the property of the U.S. Final R1 Navy.

Table of deliverables

5.0 Qualifications and TrainingSpecial

5.1 Full proficiency in English relating to correspondence, reports, manuscripts(s) and conversations with NAMRU INDO PACIFIC (e.g., during NAMRU INDO PACIFIC PO field site visits). All correspondence shall be in English. Documents in a foreign language shall be translated to English and both original and translated copies shall be delivered.

5.2 The Contractor shall ensure that all project personnel are appropriately trained for the required tasks. All team members are required to complete appropriate research training from the Collaborative Institutional Training Initiative (CITI) (http://www.

citiprogram.org) or from another institution approved by NAMRU INDO PACIFIC PO. The Contractor shall provide CITI (or another institution as approved by NAMRU INDO PACIFIC PO) certificates (upon request) confirming training requirements for all Contractor and Subcontractor (if applicable) investigators and staff involved in research for this effort.

5.3 The Contractor shall ensure that all project personnel complete training on Research Integrity, education, and misconduct.

The training material shall be provided by NAMRU INDO PACIFIC. The Contractor shall provide a list of names and dates to record the completion of such training. At NAMRU INDO PACIFIC's approval, equivalent training other than that provided by NAMRU INDO PACIFIC may be considered acceptable.

6.0 Travel Approval Contractor

The Contractor shall submit to the PO and COR a trip request authorization at least two months before anticipated travel. This is to ensure that all letters of support, coordination with visiting laboratory, local ethical approvals, IACUC and/or HRPO protocols that cover sequencing of human subject samples, animal samples, and entomological samples are submitted and approved.

7.0 Data Rights

All reports are property of the U.S. Navy. The Contractor shall not release to the public any information regarding the medical research or resulting data without the review and approval of the NAMRU INDO PACIFIC PAO. The approval process may include blanket approval for some types of information releases.

The Contractor shall submit to the NAMRU INDO PACIFIC PO and COR, or Contracting Officer for review and approval, in line with NAMRU INDO PACIFIC PAO requirements, prior to public disclosure any written publications or public relations materials (including proposed public announcements, flyers, posters, audiovisual materials, newspaper, advertisements, or mailed advertisements) which are targeted primarily to the scope of contract services or policies and programs of the Contractor.

The U.S. Government has unlimited rights to all documents/material/reports produced under this contract. All documents and materials, to include the source codes of any software, produced under this contract shall be U.S. Government owned and are the property of the U.S.

Government with all rights and privileges of ownership/copyright belonging exclusively to the U.S. Government. These documents and materials may not be used or sold by the Contractor without written permission from the Contracting Officer. All materials supplied to the U.S. Government shall be the sole property of the U.S. Government and may not be used for any other purpose. This right does not abrogate any other U.S. Government rights.

As proprietary owner and inventor of this pan-viral panel being tested and evaluated, PathoSeq Bio will likewise maintain rights to this data in order to be used for future proposals and patent applications.

8.0 Research Integrity

All parties agree to the definitions, protocol, and processes for research integrity as explained in BUMEDINST 6500.3B and DoD Instruction 3210.7.

9.0 Invoicing and Payments

All payments will be in U.S. dollars, the United States currency. Invoices shall be submitted for payment on a quarterly basis.

10.0 Protection of Human Subjects

All parties agree to the definitions, protocol, and processes for protection of human subjects in research as explained in DFARS clause 252.235-7004 (Federal Register Volume 74 Number 144, 29 July 2009) as specified below.

Requirements Next Generation Sequencing (NGS) 2026

Additional Regulation or Supplemental Clauses Incorporated by Full Text

SUPTXT242-9405(6-20) EXPEDITING CONTRACT CLOSEOUT (May 2025)

THE FOLLOWING NAVSUP LOCAL TEXT IS HEREBY MADE PART OF THE STATEMENT OF WORK

/PERFORMANCE WORK STATEMENT.

EXPEDITING CONTRACT CLOSEOUT

(a) As part of the negotiated fixed price or total estimated amount of this contract, both the Government and the Contractor have agreed to waive any entitlement that otherwise might accrue to either party in any residual dollar amount of $1,000 or less at the time of final contract closeout. The term "residual dollar amount" shall include all money that would otherwise be owed to either party at the end of the contract, except that, amounts connected in any way with taxation, allegations of fraud and/or antitrust violations shall be excluded. For purposes of determining residual dollar amounts, offsets of money owed by one party against money that would otherwise be paid by that party may be considered to the extent permitted by law.

(b) This agreement to waive entitlement to residual dollar amounts has been considered by both parties. It is agreed that the administrative costs for either party associated with collecting such small dollar amounts could exceed the amount to be recovered.

243-9400(1-92) SUPTXT243-9400(1-92) AUTHORIZED CHANGES ONLY BY THE

CONTRACTING OFFICER

(Jan 2024)

AUTHORIZED CHANGES ONLY BY THE CONTRACTING OFFICER

(a) Except as specified in paragraph (b) below, no order, statement, or conduct of Government personnel who visit the Contractor's facilities or in any other manner communicate with Contractor personnel during the performance of this contract shall constitute a change under the "Changes" clause of this contract.

(b) The Contractor shall not comply with any order, direction or request of Government personnel unless it is issued in writing and signed by the Contracting Officer, or is pursuant to specific authority otherwise included as a part of this contract.

(c) The Contracting Officer is the only person authorized to approve changes in any of the requirements of this contract and notwithstanding provisions contained elsewhere in this contract, the said authority remains solely with the Contracting Officer. In the event the Contractor effects any change at the direction of any person other than the Contracting Officer, the change will be considered to have been made without authority and no adjustment will be made in the contract price to cover any increase in charges incurred as a result thereof. The address and telephone number of the Contracting Officer is:

NAME: Jacob Gephart

ADDRESS: 700 Robbins Ave BLDG 2B Philadelphia, PA 19111

TELEPHONE: 771-229-2712

Section D - Packaging and Marking

Section E - Inspection and Acceptance

Section F - Deliveries or Performance

Line Item Delivery Schedule Quantity Address and POC

Period of Performance From 17 Aug 2026 To 16 Aug 2027

12 Months Place of Performance DoDAAC: N62814 CountryCode: SGP

NAVAL MEDICAL RESEARCH CENTER ASIA

BLDG 73-4 DEPTFORD ROAD, PSA SEMBAWANG TERMINAL

SEMBAWANG 759657

SINGAPORE

Hayley Foo, PhD, TPOC Email: hayley.s.foo.civ@health.mil Telephone: +65 9650 1755

Period of Performance From 17 Aug 2026 To 16 Aug 2027

1 Lot Place of Performance DoDAAC: N62814 CountryCode: SGP

NAVAL MEDICAL RESEARCH CENTER ASIA

BLDG 73-4 DEPTFORD ROAD, PSA SEMBAWANG TERMINAL

SEMBAWANG 759657

SINGAPORE

Hayley Foo, PhD, TPOC Email: hayley.s.foo.civ@health.mil Telephone: +65 9650 1755

Period of Performance From 17 Aug 2026 To 16 Aug 2027

1 Lot Place of Performance DoDAAC: N62814 CountryCode: SGP

NAVAL MEDICAL RESEARCH CENTER ASIA

BLDG 73-4 DEPTFORD ROAD, PSA SEMBAWANG TERMINAL

SEMBAWANG 759657

SINGAPORE

Hayley Foo, PhD, TPOC Email: hayley.s.foo.civ@health.mil Telephone: +65 9650 1755

Section G - Contract Administration Data

DFARS Clauses Incorporated by Reference

Number Title Effective Date

Alternate/ Deviation

Variation Effective Date

252.232-7003 Electronic Submission of Payment Requests and Receiving Reports. Dec 2018

DFARS Clauses Incorporated by Full Text

252.232-7006 Wide Area WorkFlow Payment Instructions. (Jan 2023)

WIDE AREA WORKFLOW PAYMENT INSTRUCTIONS (JAN 2023)

(a) As used in this clause- Definitions.

"Department of Defense Activity Address Code (DoDAAC)" is a six position code that uniquely identifies a unit, activity, or organization.

"Document type" means the type of payment request or receiving report available for creation in Wide Area WorkFlow (WAWF).

"Local processing office (LPO)" is the office responsible for payment certification when payment certification is done external to the entitlement system.

"Payment request" and "receiving report" are defined in the clause at 252.232-7003, Electronic Submission of Payment Requests and Receiving Reports.

(b) The WAWF system provides the method to electronically process vendor payment requests and receiving reports, as Electronic invoicing.

authorized by Defense Federal Acquisition Regulation Supplement (DFARS) 252.232-7003, Electronic Submission of Payment Requests and Receiving Reports.

(c) To access WAWF, the Contractor shall- WAWF access.

(1) Have a designated electronic business point of contact in the System for Award Management at https://www.sam.gov; and

(2) Be registered to use WAWF at https://wawf.eb.mil/ following the step-by-step procedures for self-registration available at this web site.

(d) The Contractor should follow the training instructions of the WAWF Web-Based Training Course and use the Practice WAWF training.

Training Site before submitting payment requests through WAWF. Both can be accessed by selecting the "Web Based Training" link on the WAWF home page at https://wawf.eb.mil/

(e) Document submissions may be via web entry, Electronic Data Interchange, or File Transfer WAWF methods of document submission.

Protocol.

(f) The Contractor shall use the following information when submitting payment requests and receiving reports WAWF payment instructions.

in WAWF for this contract or task or delivery order:

(1) The Contractor shall submit payment requests using the following document type(s): Document type.

(i) For cost-type line items, including labor-hour or time-and-materials, submit a cost voucher.

(ii) For fixed price line items-

(A) That require shipment of a deliverable, submit the invoice and receiving report specified by the Contracting Officer.

(Contracting Officer: Insert applicable invoice and receiving report document type(s) for fixed price line items that require shipment of a deliverable.)

(B) For services that do not require shipment of a deliverable, submit either the Invoice 2in1, which meets the requirements for the invoice and receiving report, or the applicable invoice and receiving report, as specified by the Contracting Officer.

(Contracting Officer: Insert either "Invoice 2in1" or the applicable invoice and receiving report document type(s) for fixed price line items for services.)

(iii) For customary progress payments based on costs incurred, submit a progress payment request.

(iv) For performance based payments, submit a performance based payment request.

(v) For commercial financing, submit a commercial financing request.

(2) ) Fast Pay requests are only permitted when Federal Acquisition Regulation (FAR) 52.213-1 is included in the contract.

[Note: The Contractor may use a WAWF "combo" document type to create some combinations of invoice and receiving report in one step.]

(3) The Contractor shall use the information in the Routing Data Table below only to fill in applicable fields in Document routing.

WAWF when creating payment requests and receiving reports in the system.

Routing Data Table*

Field Name in WAWF Data to be entered in WAWF

Pay Official DoDAAC ____

Issue By DoDAAC ____

Admin DoDAAC ____

Inspect By DoDAAC ____

Ship To Code ____

Ship From Code ____

Mark For Code ____

Service Approver (DoDAAC) ____

Service Acceptor (DoDAAC) ____

Accept at Other DoDAAC ____

LPO DoDAAC ____

DCAA Auditor DoDAAC ____

Other DoDAAC(s) ____

(*Contracting Officer: Insert applicable DoDAAC information. If multiple ship to/acceptance locations apply, insert "See Schedule" or "Not applicable.")

(**Contracting Officer: If the contract provides for progress payments or performance-based payments, insert the DoDAAC for the contract administration office assigned the functions under FAR 42.302(a)(13).)

(4) The Contractor shall ensure a payment request includes documentation appropriate to the type of payment request in Payment request.

accordance with the payment clause, contract financing clause, or Federal Acquisition Regulation 52.216-7, Allowable Cost and Payment, as applicable.

(5) The Contractor shall ensure a receiving report meets the requirements of DFARS Appendix F. Receiving report.

(g) WAWF point of contact.

(1) The Contractor may obtain clarification regarding invoicing in WAWF from the following contracting activity's WAWF point of contact.

(Contracting Officer: Insert applicable information or "Not applicable.")

(2) Contact the WAWF helpdesk at 866-618-5988, if assistance is needed.

(End of clause)

Section H - Special Contract Requirements

Section I - Contract Clauses

FAR Clauses Incorporated by Reference

Number Title Effective Date

Alternate/ Deviation

Variation Effective Date

52.203-12 Limitation on Payments to Influence Certain Federal Transactions. Jun 2020 52.203-19 Prohibition on Requiring Certain Internal Confidentiality Agreements or Statements. Jan 2017 52.204-13 System for Award Management-Maintenance. (Deviation 2026-O0038) Feb 2026

52.209-6 Protecting the Government's Interest When Subcontracting With Contractors Debarred, Suspended, Proposed for Debarment, or Voluntarily Excluded. (Deviation 2026-O0038)

Feb 2026

52.209-10 Prohibition on Contracting With Inverted Domestic Corporations. (Deviation 2026- O0038)

Feb 2026

52.212-4 Terms and Conditions-Commercial Products and Commercial Services. (Deviation 2026- O0038)

Feb 2026

52.222-3 Convict Labor. (Deviation 2026-O0038) Feb 2026 52.222-35 Equal Opportunity for Veterans. (Deviation 2026-O0038) Feb 2026 52.222-36 Equal Opportunity for Workers with Disabilities. (Deviation 2026-O0038) Feb 2026 52.222-50 Combating Trafficking in Persons. (Deviation 2026-O0038) Feb 2026

52.222-90 Addressing DEI Discrimination by Federal Contractors. (Deviation 2026-O0040, Revision 1)

Apr 2026

52.226-8 Encouraging Contractor Policies to Ban Text Messaging While Driving. May 2024 52.232-33 Payment by Electronic Funds Transfer-System for Award Management. Oct 2018 52.232-39 Unenforceability of Unauthorized Obligations. Jun 2013 52.232-40 Providing Accelerated Payments to Small Business Subcontractors. Mar 2023 52.233-3 Protest after Award. (Deviation 2026-O0038) Feb 2026 52.233-4 Applicable Law for Breach of Contract Claim. (Deviation 2026-O0038) Feb 2026 52.240-91 Security Prohibitions and Exclusions. (Deviation 2026-O0038) Feb 2026

52.244-6 Subcontracts for Commercial Products and Commercial Services. (Deviation 2026- O0038)

Apr 2026

52.245-1 Government Property. Sep 2021 52.245-9 Use and Charges. Apr 2012

DFARS Clauses Incorporated by Reference

Number Title Effective Date

Alternate/ Deviation

Variation Effective Date

252.203-7000 Requirements Relating to Compensation of Former DoD Officials. Sep 2011 252.203-7002 Requirement to Inform Employees of Whistleblower Rights. Dec 2022

252.204-7012 Safeguarding Covered Defense Information and Cyber Incident Reporting.

(DEVIATION 2024-O0013 REVISION 1)

May 2024 Deviation 2024-O0013 May 2024

252.204-7015 Notice of Authorized Disclosure of Information for Litigation Support. Jan 2023

252.204-7018 Prohibition on the Acquisition of Covered Defense Telecommunications Equipment or Services.

Jan 2023

252.204-7022 Expediting Contract Closeout. May 2021

252.209-7004 Subcontracting with Firms that are Owned or Controlled by the Government of a Country that is a State Sponsor of Terrorism.

May 2019

252.225-7012 Preference for Certain Domestic Commodities. Apr 2022 252.225-7048 Export-Controlled Items. Jun 2013 252.225-7056 Prohibition Regarding Business Operations with the Maduro Regime. Jan 2023

252.225-7060 Prohibition on Certain Procurements from the Xinjiang Uyghur Autonomous Region.

Jun 2023

252.225-7972 Prohibition on the Procurement of Foreign-Made Unmanned Aircraft Systems. (DEVIATION 2024-O0014)

Aug 2024 Deviation 2024-O0014 Aug 2024

252.227-7990 Technical Data--Commercial Products and Commercial Services.

(DEVIATION 2026-O0036)

Feb 2026 Deviation 2026-O0036 Feb 2026

252.232-7010 Levies on Contract Payments. Dec 2006 252.237-7010 Prohibition on Interrogation of Detainees by Contractor Personnel. Jan 2023

252.240-7997 NIST SP 800-171 DoD Assessment Requirements. (DEVIATION 2026- O0025)

Feb 2026 Deviation 2026-O0025 Feb 2026

252.244-7999 Subcontracts for Commercial Products or Commercial Services.

(DEVIATION 2026-O0015)

Feb 2026 Deviation 2026-O0015 Jan 2026

252.245-7003 Contractor Property Management System Administration Jan 2025 252.245-7005 Management and Reporting of Government Property. Jan 2024 252.247-7023 Transportation of Supplies by Sea. Oct 2024

FAR Clauses Incorporated by Full Text

52.219-28 Postaward Small Business Program Rerepresentation. (Deviation 2026-O0038) (Feb 2026)

POSTAWARD SMALL BUSINESS PROGRAM REREPRESENTATION (FEB 2026) (DEVIATION 2026-O0038)

(a) . As used in this clause-Definitions

Long-term contract means a contract of more than five years in duration, including options. However, the term does not include contracts that exceed five years in duration because the period of performance has been extended for a cumulative period not to exceed six months under the clause at 52.217-8, Option to Extend Services, or other appropriate authority.

Small business concern-

(1) Means a concern, including its affiliates, that is independently owned and operated, not dominant in its field of operation, and qualified as a small business under the criteria in 13 CFR part 121 and the size standard in paragraph (c) of this clause.

(2) , as used in this definition, means business concerns, one of whom directly or indirectly controls or has the power to control the others, Affiliates or a third party or parties control or have the power to control the others. In determining whether affiliation exists, consideration is given to all appropriate factors including common ownership, common management, and contractual relationships. SBA determines affiliation based on the factors set forth at 13 CFR 121.103.

(b) If the Contractor represented that it was a small business concern, a small disadvantaged business concern, or a joint venture that was any of the small business concerns identified in 19.000(a)(3) prior to award of this contract, the Contractor shall rerepresent its size and socioeconomic status according to paragraph (e) of this clause or, if applicable, paragraph (g) of this clause, upon occurrence of any of the following:

(1) Within 30 days after execution of a novation agreement or within 30 days after modification of the contract to include this clause, if the novation agreement was executed prior to inclusion of this clause in the contract.

(2) Within 30 days after a merger or acquisition that does not require a novation or within 30 days after modification of the contract to include this clause, if the merger or acquisition occurred prior to inclusion of this clause in the contract.

(3) For long-term contracts-

(i) Within 60 to 120 days prior to the end of the fifth year of the contract; and

(ii) Within 60 to 120 days prior to the date specified in the contract for exercising any option thereafter.

(c) The Contractor shall rerepresent its size status in accordance with the size standard in effect at the time of this rerepresentation that corresponds to the North American Industry Classification System (NAICS) code(s) assigned to this contract. The small business size standard corresponding to this NAICS code(s) can be found at https://www.sba.gov/document/support--table-size-standards.

(d) The small business size standard for a Contractor providing an end item that it does not manufacture, process, or produce itself, for a contract other than a construction or service contract, is 500 employees, or 150 employees for information technology value-added resellers under NAICS code 541519, if the acquisition-

(1) Was set aside for small business and has a value above the simplified acquisition threshold;

(2) Used the HUBZone price evaluation preference regardless of dollar value, unless the Contractor waived the price evaluation preference; or

(3) Was an 8(a), HUBZone, service-disabled veteran-owned, economically disadvantaged women-owned, or women-owned small business set-aside or sole-source award regardless of dollar value.

(e) Except as provided in paragraph (g) of this clause, the Contractor shall make the representation(s) required by paragraph (b) of this clause by validating or updating all its representations in the Representations and Certifications section of the System for Award Management (SAM) and its other data in SAM, as necessary, to ensure that they reflect the Contractor's current status. The Contractor shall notify the contracting officer in writing within the timeframes specified in paragraph (b) of this clause, that the data have been validated or updated, and provide the date of the validation or update.

(f) If the Contractor represented that it was other than a small business concern prior to award of this contract, the Contractor may, but is not required to, take the actions required by paragraphs (e) or (g) of this clause.

(g) If the Contractor does not have representations and certifications in SAM, or does not have a representation in SAM for the NAICS code applicable to this contract, the Contractor is required to complete the following rerepresentation and submit it to the contracting office, along with the contract number and the date on which the rerepresentation was completed:

(1) The Contractor represents that it is, is not a small business concern under NAICS Code assigned to contract number.____ ____

(2) [ .] The Contractor represents Complete only if the Contractor represented itself as a small business concern in paragraph (g)(1) of this clause that it is, is not, a small disadvantaged business concern as defined in .13 CFR 124.1001

(3) . The Contractor represents that it is, is not a Women-owned small business (WOSB) joint venture eligible under the WOSB Program joint venture that complies with the requirements of 13 CFR 127.506(a) through (c). [ The Contractor shall enter the name and unique entity ____ identifier of each party to the joint venture: __.]

(4) . The Contractor represents that it is, is not a joint Economically disadvantaged women-owned small business (EDWOSB) joint venture venture that complies with the requirements of 13 CFR 127.506(a) through (c). [ The Contractor shall enter the name and unique entity identifier ____ of each party to the joint venture: __ .]

(5) . The Contractor represents that it Service-disabled veteran-owned small business (SDVOSB) joint venture eligible under the SDVOSB Program is, is not an SDVOSB joint venture eligible under the SDVOSB Program that complies with the requirements of 13 CFR 128.402. [ The ____ Contractor shall enter the name and unique entity identifier of each party to the joint venture: __.]

(6) [ ] The HUBZone joint venture eligible under the HUBZone Program. Complete only if the offeror is a HUBZone small business concern.

offeror represents, as part of its offer, that It is, is not a HUBZone joint venture that complies with the requirements of 13 CFR 126.616(a) through (c). [ The Contractor shall enter the name and unique entity identifier of each party to the joint venture: .] Each HUBZone small business ____ concern participating in the HUBZone joint venture must be certified as a HUBZone concern. [ Contractor to sign and date and insert authorized ____ signer's name and title.]

(End of clause)

52.252-2 Clauses Incorporated by Reference. (Feb 1998)

Clauses Incorporated By Reference (Feb 1998)

This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at this/these address(es):

https://www.acquisition.gov/far-overhaul/far-part-deviation-guide/far-overhaul-part-52 and https://www.acq.osd.mil/dpap/dars /dfars_far_overhaul_class_deviations.html

(End of clause)

52.252-6 Authorized Deviations in Clauses. (Nov 2020)

Authorized Deviations in Clauses (Nov 2020)

(a) The use in this solicitation or contract of any Federal Acquisition Regulation (48 CFR Chapter 1) clause with an authorized deviation is indicated by the addition of "(DEVIATION)" after the date of the clause.

(b) The use in this solicitation or contract of any (48 CFR ) clause with an authorized deviation is indicated by the addition of DFARS 2 "(DEVIATION)" after the name of the regulation.

(End of clause)

DFARS Clauses Incorporated by Full Text

252.225-7963 Antiterrorism/Force Protection for Defense Contractors Outside the United States. (DEVIATION 2026-O0041)

(Feb 2026) Deviation 2026-O0041 (Feb 2026)

ANTITERRORISM/FORCE PROTECTION POLICY FOR DEFENSE CONTRACTORS OUTSIDE THE UNITED STATES(DEVIATION

2026-O0041) (FEB 2026)

(a) . “United States,” as used in this clause, means, the 50 States, the District of Columbia, and outlying…