Solicitation 75D301-20-R-68011.doc

REQUEST FOR QUOTATIONS

(THIS IS NOT AN ORDER)

THIS RFQ

PAGE OF PAGES

1. REQUEST NO.

75D301-20-R-68011

2. DATE ISSUED

08/10/2020

3. REQUISITION/PURCHASE REQUEST NO.

00HCUCPE-2020-48934

4. CERT. FOR NAT. DEF.

UNDER BDSA REG. 2

AND/OR DMS REG. 1

RATING

5a. ISSUED BY

Centers for Disease Control and Prevention (CDC)

Office of Acquisition Services (OAS)

2900 Woodcock Blvd, MS TCU-4

Atlanta GA 303414004

6. DELIVERY BY (Date)

5b. FOR INFORMATION CALL (No collect calls)

c. CITY

10. PLEASE FURNISH QUOTATIONS TO

THE ISSUING OFFICE IN BLOCK 5a ON

OR BEFORE CLOSE OF BUSINESS (Date)

IMPORTANT: This is a request for information, and quotations furnished are not offers. If you are unable to quote, please so indicate on this form and return it. This request does not commit the Government to pay any costs incurred in the preparation of the submission of this quotation or to contract for supplies or services. Supplies are of domestic origin unless otherwise indicated by quoter. Any representations and/or certifications attached to this Request for Quotations must be completed by the quoter.

11. SCHEDULE (Include applicable Federal, State and local taxes)

ITEM NO.

(a)

SUPPLIES/SERVICES

(b)

QUANTITY

(c)

UNIT

(d)

UNIT PRICE

(e)

AMOUNT

(f)

This Request for Quotations (RFQ) is issued to obtain pricing for required for the Estimates of Alcohol-Attributable Deaths and Years of Potential Life Lost in the United States and Analytic Methods

This will be a Firm Fixed Price contract.

Please email questions and quotes Contract Administrator: Rotravius (Tray) A. Burch

Telephone #: 770-488-2457

E-mail: vwa8@cdc.gov

Deadline for questions: August 14, 2020 Deadline for quotes: August 24, 2020

b. 20 CALENDAR DAYS

c. 30 CALENDAR DAYS

d. CALENDAR DAYS

NOTE: Additional provisions and representations

SIGN QUOTATION

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QUOTATION

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AREA CODE

AUTHORIZED FOR LOCAL REPRODUCTION

STANDARD FORM 18 (REV. 6-95)

Previous edition not usable

Prescribed by GSA

FAR (48 CFR) 53.215-1(a)

SECTION B - SUPPLIES OR SERVICES AND PRICES/COST

Base Year – 09/30/2020 – 09/29/2021

The Estimates of Alcohol-Attributable Deaths and Years of Potential Life Lost in the United States and Analytic Methods as described in the Statement of Work in Section C.

FFP

NonSeverable

POP: 09/30/2020 - 09/29/2021

1 Dollars, U.S.

Option Year 1 – 09/30/2021 – 09/29/2022

The Estimates of Alcohol-Attributable Deaths and Years of Potential Life Lost in the United States and Analytic Methods as described in the Statement of Work in Section C.

FFP

NonSeverable

POP: 09/30/2021 - 09/29/2022

1 Dollars, U.S.

Option Year 2 – 09/30/2022 – 09/29/23

The Estimates of Alcohol-Attributable Deaths and Years of Potential Life Lost in the United States and Analytic Methods as described in the Statement of Work in Section C.

FFP

NonSeverable

POP: 09/30/2022 - 09/29/2023

1 Dollars, U.S.

Contract Type: Firm-Fixed Price Period of Performance: Base Period of 12 Months plus two 12 month option periods

NAICS Code for this procurement is 518210: Data Processing, Hosting, and Related Services with a size standard of $32,500,000.00.

This acquisition is being issued in accordance with FAR Part 15, Contracting by Negotiation.

Full and Open Competition.

Section C - Statement of Work Title: Estimates of Alcohol-Attributable Deaths and Years of Potential Life Lost in the United States and Analytic Methods

Excessive alcohol use contributed to an average of 88,000 deaths and 2.5 million years of potential life lost in the U.S. each year during 2006 – 2010, and cost the U.S. $249 billion in 2010. Excessive alcohol use is associated with a range of health and social problems, including chronic conditions such as liver cirrhosis, high blood pressure, and various types of cancer, as well as acute conditions, such as motor vehicle traffic crashes, violence, injuries, and drug overdoses. Reducing deaths attributable to excessive alcohol use is a health objective in Healthy People 2020 (Substance Abuse-20).

The Centers for Disease Control and Prevention’s Alcohol-Related Disease Impact (ARDI) application is a widely used online application (www.cdc.gov/ardi) that provides national and state estimates of alcohol-related health impacts, including deaths and years of potential life lost, from more than 50 acute and chronic causes of death. These estimates are calculated using alcohol-attributable fractions. Specifically, alcohol-attributable deaths are estimated in ARDI by multiplying the total number of deaths due to an underlying cause from any of the alcohol-related conditions in the ARDI application by its alcohol attributable fraction. Some conditions are wholly (100%) alcohol-attributable (e.g., alcoholic liver cirrhosis) and have an alcohol attributable fraction of 1.0. Other conditions are partially alcohol-attributable (e.g., breast cancer, hypertension) and have an alcohol attributable fraction <1.0. In general, the alcohol attributable fractions for chronic conditions are calculated using relative risks from published literature and the prevalence of average daily alcohol consumption (at low, medium, and high levels) among U.S. adults, based on the Behavioral Risk Factor Surveillance System. The prevalence estimates used in ARDI are adjusted to account for a portion of the underreporting of alcohol use during binge drinking episodes (Stahre et al., 2006). However, alternative methods have also been developed to adjust for the underreporting of alcohol use in surveys, such as statistically adjusting the prevalence of self-reported alcohol consumption using per capita alcohol sales information (Nelson et al., 2010; Rey et al., 2010).

The ARDI application can be used to estimate national and state level estimates of average annual alcohol-attributable deaths and years of potential life lost due to excessive alcohol use (including deaths from conditions that are 100% alcohol-attributable, acute conditions that involved binge drinking, and chronic conditions that involved medium or high average daily alcohol consumption) by age group. An analysis of data from ARDI found that one in ten deaths among working age adults (aged 20 – 64 years) were due to excessive alcohol use during 2006 – 2010 (Stahre et al., 2014). However, the estimated percentage of deaths due to excessive alcohol use among this age group relative to total deaths in the U.S. may differ if alternative methods are used to account for the underreporting of alcohol use in the Behavioral Risk Factor Surveillance System.

In addition, in ARDI, deaths due to liver disease are estimated separately by specific conditions, such as alcoholic liver disease, which is wholly attributable to alcohol, and unspecified liver cirrhosis, which is partially attributable to alcohol. However, alternative methods also have been used in other studies that model the risk of chronic liver cirrhosis by level of average daily alcohol consumption without separately assessing deaths by the type of liver disease (Roerecke et al., 2019). Studies have not been conducted to empirically compare estimates of alcohol-attributable liver disease deaths generated using the method in ARDI and estimates generated using models to calculate alcohol-related chronic liver disease deaths based on the risk of dying at different levels of alcohol consumption.

Unlike the ARDI methods for assessing alcohol-attributable deaths from chronic conditions, in general, the alcohol-attributable fractions in ARDI for acute non-traffic related causes are based on estimates of the proportion of decedents who had a blood alcohol concentration ≥0.10 g/dL by cause of death. For motor vehicle crash deaths, the alcohol attributable fractions are based on the proportion of crash deaths that involved a blood alcohol concentration ≥0.08 g/dL, using data from the National Highway Traffic Safety Administration’s Fatality Analysis Reporting System. In the ARDI application, an alcohol-attributable fraction of <1.0 is assigned to each acute condition that is partially attributable to alcohol use (including deaths from air-space transport, aspiration, child maltreatment, drownings, drug poisonings (not alcohol poisoning), fall injuries, fire injuries, firearm injuries, homicide, hypothermia, motor vehicle traffic crashes, motor vehicle non-traffic crashes, other road vehicle crashes, occupational and machinery injuries, suicide, and water transportation) and the estimated number of alcohol-attributable deaths due to each of these causes is calculated based on a proportion of total deaths. Other methodologies have been developed to estimate the number of alcohol-related deaths from acute conditions using statistical modeling techniques to calculate deaths due to motor vehicle crashes, unintentional injuries, and intentional injuries by (Shield et al. 2016; Sherk et al. 2017). An advantage to using the modelling approach is that it takes into account factors such as the population’s drinking patterns. Estimates of the number of alcohol-attributable deaths from acute conditions based on the direct alcohol-attributable fractions in ARDI have not been compared with estimates generated from models that include data on alcohol use for the U.S. population. This comparison would be useful for guiding future ARDI methods.

In addition to these methodologic analyses, analyses using the most recent data on the prevalence of alcohol consumption would ensure that ARDI data are timely, which is important for informing public health practice in states. The estimated alcohol-attributable deaths and years of potential life lost for 2011 – 2015 are expected to be published and available in ARDI in 2020; however, more recent years of data can also be analyzed for future updates to the ARDI application. Using the most recent data available, analyses such as exploring state-specific changes in alcohol-attributable deaths over time, while adjusting for the underreporting of alcohol use; and examining the distribution of age at death by categories of causes of death (e.g., cancer, heart disease and stroke, motor vehicle traffic crashes) and years of potential life lost might provide further data to inform the development and implementation of evidence-based population-level strategies for preventing excessive alcohol use in states and communities across the country.

SECTION 2 – PURPOSE

The purpose of this acquisition is to fund a contractor to: 1) assist in estimating national and state-specific alcohol-attributable deaths and years of potential life lost by analyzing data on alcohol consumption among U.S. adults from the Behavioral Risk Factor Surveillance System and on per capita alcohol sales from the Alcohol Epidemiologic Data System; and 2) lead the publication of three manuscripts, including conducting analyses and drafting the articles, to examine methodologic alternatives for estimating the average annual number of alcohol-attributable deaths due to liver disease and due to acute conditions (e.g., non-traffic injuries), as well as one that examines the distribution of age at death by categories of alcohol-attributable deaths. The contractor will perform these analyses primarily using the following: data on the prevalence of alcohol consumption from the Behavioral Risk Factor Surveillance System; data on alcohol sales from the Alcohol Epidemiologic Data System; relative risks and alcohol-attributable fractions from the ARDI application; and mortality data aggregated by cause of death (according to ICD-10 codes used in ARDI), acquired and prepared by the CDC Alcohol Program.

The results of these analyses and series of studies will highlight the magnitude of the public health burden of excessive alcohol use in states and will inform future methods for estimating alcohol-attributable deaths and years of potential life lost in the ARDI application.

SECTION 3 – SCOPE OF WORK

The CDC Alcohol Program is seeking a contractor to analyze data used for estimating alcohol-attributable deaths and years of potential life lost in the ARDI application and co-author three associated publications, which will be led by the CDC Alcohol Program, including the following deliverables: 1) results from analyses of the number of average annual deaths and years of potential life lost due to excessive alcohol use among working-age U.S. adults (aged 20 – 64 years) during 2011 – 2015, using both the current ARDI methods for adjusting the prevalence of alcohol consumption data as well as adjusting prevalence estimates based on per capita alcohol sales; 2) results from analyses of 2016 – 2020 U.S. and state data on the adjusted prevalence average daily alcohol consumption (low, medium, and high), using six different cut-points for defining the levels of average daily alcohol consumption, for use in estimating average annual deaths and years of potential life lost due to excessive alcohol use in the U.S. and in states; and 3) results from analyses of state-specific prevalence of average daily alcohol consumption data during the past 2 decades (averages of 5-year time periods for 2001 – 2005, 2006 – 2010, 2011 – 2015, and 2016 – 2020), using methods that adjust for the underreporting of alcohol use in surveys, to contribute to analyses on trends in the number of deaths due to excessive alcohol use nationally and by state.

In addition, the contractor will also be expected to perform methodologic analyses and lead two associated manuscripts for publication in peer-reviewed journals that examine the approaches used in the ARDI application for estimating alcohol-attributable deaths due to liver disease in the U.S., as well as alcohol-attributable acute causes of deaths (e.g., non-traffic injuries). Finally, the contractor will be expected to lead a third manuscript for publication in a peer-reviewed journal that examines the distribution of age at distribution of age at death and years of potential life lost by categories of causes of alcohol-attributable deaths (e.g., cancer, heart disease and stroke, motor vehicle traffic crashes). The contractor will be expected to consult with the CDC Alcohol Program on methodologic and analytical decisions, as well as to collaborate in drafting and revising the text for the articles.

Since this research involves the analysis of secondary data on decedents, no new data on human subjects will be collected. The data also will be analyzed in aggregate, and no personally identifiable information will be reported.

SECTION 4 – TASKS TO BE PERFORMED

TASK 1. Project management

a. Kickoff Meeting - A kickoff meeting shall be held no later than 20 working days after the initial award is made to discuss study plans and timelines, as well as to clarify roles and responsibilities.

b. Work Plan – Within 20 working days after the kick off meeting, the contractor shall develop a written work plan for Review and approval by the Contracting Officer’s Representative (COR) and CDC Alcohol Program scientific lead that includes all the key steps for completing the analyses, participating as a co-author on three articles, and leading three manuscripts (see below), as well as the essential interim and final deliverables; a description of the key staff who are responsible for tasks (including the contractor, CDC Alcohol Program, or other partners); a proposed schedule of key deadlines (including review cycles and absolute No Later Than (NLT) dates for key activities and deliverables); and updates and clarifications to the tasks that were included in the original project proposal. The work plan must also contain the specific project-related activities to be developed by the contractor during the course of the project, including the contractor’s plan for ongoing monitoring and evaluating their services to assure highly quality performance and customer satisfaction. The work plan should also discuss the contractor’s plan for employee management including how the contractor will avoid any appearances of personal services to the CDC. The work plan should be suitable for sharing with key CDC management/staff, as needed. The work plan (and any schedule of interim deliverables) may be subsequently revised pending COR approval of the updated work plan, as long as these changes don’t impact the overall period of performance, scope, or specifications of the award; or otherwise impinge on the authority of the contracting officer. It is the responsibility of the contractor to fully understand what changes require contracting officer approval.

c. Monthly Reporting – Provide a monthly report to the COR and the CDC Alcohol Program scientific lead for review and approval by the 5th calendar day of each month, including updates on the deliverables as described in the work plan. The monthly report shall be considered a substantial deliverable of the project, and used as a tool for monitoring the success of the project, and documentation of effort/services as invoiced in the matching monthly invoice. The contractor shall develop the monthly report format for review and approval by the COR.

d. Monthly Conference Call – A monthly conference call with the COR, and/or the CDC Alcohol Program scientific lead, initiated and led by the contractor must be held each month. The purpose of this call is to review progress on the work plan, including task performance. The discussion from the conference call must be documented in the following monthly report. Any required performance improvements must be documented and reported in the monthly reports.

e. Scientific Consultation Discussions – Conference calls to discuss scientific aspects of the analyses or manuscripts with the CDC Alcohol Program scientific lead should be initiated by the contractor periodically as methodologic or analytic questions arise. The purpose of the scientific consultation conference calls is to discuss methodologic aspects of the analyses and studies in more detail than may be possible during the monthly conference calls.

TASK 2. Conduct analyses of deaths and years of potential life lost due to excessive alcohol use among working-age U.S. adults (20 – 64 years)

a. The contractor is expected to conduct the following analyses, pertaining to average annual estimates during 2011 – 2015:

i. The number of total deaths among working-age adults in the U.S. overall and by state.

ii. The total number of alcohol-attributable deaths among working-age adults in the U.S. overall and by state, using two methodologies: first, based on the ARDI methodology; and second, based on a methodology that adjusts for the underreporting of alcohol consumption in surveys using per capita alcohol sales information.

iii. Percentage of total deaths attributable to alcohol among working-age adults in the U.S. overall and by state, for estimates generated using the two methodologies.

iv. The total number of total years of potential life lost among working-age adults in the U.S. overall and by state. The years of potential life lost are calculated by multiplying the age- and sex-specific alcohol-attributable deaths by the corresponding reduction in years of life potentially remaining for decedents relative to average life expectancies.

v. The total number of years of potential life lost among working-age adults in the U.S. overall and by state, using two methodologies: first, based on the ARDI methodology; and second, based on a methodology that adjusts for the underreporting of alcohol consumption in surveys using per capita alcohol sales information.

vi. Percentage of total years of potential life lost attributable to alcohol among working-age adults in the U.S. overall and by state, for estimates generated using the two methodologies.

b. The contractor will deliver results of analyses with the CDC Alcohol Program and address questions and suggestions, as needed.

c. The contractor will also participate as a co-author on a CDC-led publication, including the following:

i. Draft the methods section of the article, in accordance with the journal formatting guidelines.

ii. Review and provide comments on drafts of the article.

iii. Address analytic questions and revise analyses, if requested, in response to feedback from reviewers at the CDC, from a journal, or both.

TASK 3. Assess methodologic options for estimating alcohol-attributable liver disease deaths in the U.S.

a. The contractor is expected to develop an analytic plan and submit it to CDC for review describing analyses that will compare estimates of alcohol-attributable liver disease deaths in the U.S. during 2011 – 2015 generated using the method in ARDI with direct alcohol-attributable fractions and estimates generated using statistical modeling techniques to calculate alcohol-related chronic liver disease deaths based on the risk of dying at different levels of alcohol consumption.

b. The contractor will submit results from analyses on methodologic alternatives for estimating average annual alcohol-attributable liver disease deaths to the CDC.

c. The contractor will address questions and suggestions from the CDC Alcohol Program, as needed on the analytic plan and results of analyses.

d. Prepare a manuscript for publication in a peer-reviewed journal, including the following:

i. Lead the development of a manuscript, in collaboration with the CDC Alcohol Program.

ii. The contractor and the CDC Alcohol Program will choose a target journal, and the contractor will format the manuscript according to the journal standards and guidelines for submission. The contractor will then submit a draft of the manuscript to the CDC Alcohol Program scientific lead for review, and the contractor will respond to comments provided by CDC, and submit revised drafts of the manuscript to the CDC Alcohol Program.

iii. After the contractor has addressed all feedback from the CDC Alcohol Program, the manuscript will be submitted to the CDC clearance process with the CDC Alcohol Program scientific lead as a co-author. The contractor then will be expected to work with the CDC Alcohol Program to respond to comments received through the clearance process. After the manuscript has been cleared, the contractor will submit the cleared version of the manuscript to the target journal.

iv. In collaboration with all co-authors and the CDC Alcohol Program, the contractor will respond to comments from journal peer-reviewers and journal editors. If the article is not accepted by the target journal, the contractor will be expected to work with the CDC Alcohol Program to select another journal(s) to submit it to, and then work with the CDC Alcohol Program to help assure a successful outcome for the manuscript.

TASK 4. Assess methodologic options for estimating alcohol-attributable deaths due to acute causes

a. The contractor is expected to develop an analytic plan and submit it to CDC for review describing methodologic analyses on estimating the average annual number of alcohol-attributable deaths due to acute causes (e.g., non-traffic injuries) in the U.S. during 2011 – 2015. Acute causes of alcohol-related deaths include air-space transport, aspiration, child maltreatment, drownings, drug poisonings (not alcohol poisoning), fall injuries, fire injuries, firearm injuries, homicide, hypothermia, motor vehicle traffic crashes, motor vehicle non-traffic crashes, other road vehicle crashes, occupational and machinery injuries, suicide, and water transportation. Alcohol-attributable fractions for estimating alcohol-attributable deaths due to motor vehicle traffic crashes will come from the ARDI application, which uses data from the National Highway Traffic Safety Administration’s Fatality Analysis Reporting System. The analytic plan should explain analyses that will compare estimates of alcohol-attributable deaths from acute conditions generated using the method in ARDI with direct alcohol-attributable fractions and estimates generated using statistical modeling techniques. The contractor will propose the statistical modeling techniques based on published literature and address questions and suggestions from the CDC Alcohol Program.

b. The contractor will submit results to the CDC from analyses that compare estimates of alcohol-attributable deaths from acute conditions generated using the method in ARDI with direct alcohol-attributable fractions and estimates generated using statistical modeling techniques. The contractor is expected to address questions and suggestions from the CDC Alcohol Program, as needed, on the results of analyses.

c. Prepare a manuscript for publication in a peer-reviewed journal, including the following:

i. Lead the development of a manuscript, in collaboration with the CDC Alcohol Program.

ii. The contractor and the CDC Alcohol Program will choose a target journal, and the contractor will format the manuscript according to the journal standards and guidelines for submission. The contractor will then submit a draft of the manuscript to the CDC Alcohol Program scientific lead for review, and the contractor will respond to comments provided by CDC, and submit revised drafts of the manuscript to the CDC Alcohol Program.

iii. After the contractor has addressed all feedback from the CDC Alcohol Program, the manuscript will be submitted to the CDC clearance process with the CDC Alcohol Program scientific lead as a co-author. The contractor then will be expected to work with the CDC Alcohol Program to respond to comments received through the clearance process. After the manuscript has been cleared, the contractor will submit the cleared version of the manuscript to the target journal.

iv. In collaboration with all co-authors and the CDC Alcohol Program, the contractor will respond to comments from journal peer-reviewers and journal editors. If the article is not accepted by the target journal, the contractor will be expected to work with the CDC Alcohol Program to select another journal(s) to submit it to, and then work with the CDC Alcohol Program to help assure a successful outcome for the manuscript.

TASK 5. Conduct national and state-specific analyses of recent data on the prevalence of average daily alcohol consumption among U.S. adults

a. Using the 2016 – 2020 Behavioral Risk Factor Surveillance System, the contractor is expected to conduct analyses pertaining to average annual prevalence of alcohol use, including the following stratifications: prevalence of average daily alcohol consumption at 3 levels (low, medium, and high) for males and females, overall for the U.S. and by state (and the District of Columbia). The levels of average daily alcohol consumption are defined in ARDI in 6 slightly different ways, depending on the cause of death and the source of the alcohol-attributable fraction. The 6 sets of cut-points used for defining low, medium, and high average daily alcohol consumption will be provided to the contractor by the CDC Alcohol Program. All prevalence estimates will be adjusted using two adjustment methods: adjust for a portion of the underreporting of alcohol use during binge drinking episodes (Stahre et al., 2006) and by a proportion of per capita alcohol sales (Rey et al., 2010). There will be 36 prevalence point estimates nationally and for each state resulting from each method, yielding a total of 72 prevalence point estimates nationally and for each state.

b. The contractor will deliver results of analyses with the CDC Alcohol Program and address questions and suggestions, as needed.

c. The contractor will also participate as a co-author on a CDC-led publication, including the following:

iv. Draft the methods section of the article, in accordance with the journal formatting guidelines.

v. Review and provide comments on drafts of the article.

vi. Address analytic questions and revise analyses, if requested, in response to feedback from reviewers at the CDC, from a journal, or both.

TASK 6. Conduct analyses on trends in the prevalence of average daily alcohol consumption among U.S. adults

a. The contractor is expected to contribute to analyses of trends in the number of alcohol-attributable deaths nationally and by state, in collaboration with the CDC, by performing analyses to estimate the prevalence of average daily alcohol consumption at 3 levels (low, medium, and high) – as described in Task 5, bullet A – for each of the following 4 time periods to calculate 5-year average annual estimates during the past 2 decades: 2001 – 2005, 2006 – 2010, 2011 – 2015, and 2016 – 2020. The prevalence estimates will be adjusted using one method to account for the underreporting of alcohol use in surveys. Using the prevalence estimates generated by the contractor, the CDC will perform analyses to estimate the number of alcohol-attributable deaths during 2001 – 2020.

b. The contractor will deliver results of analyses with the CDC Alcohol Program and address questions and suggestions, as needed.

c. The contractor will also participate as a co-author on a CDC-led publication, including the following:

vii. Draft the methods section of the article, in accordance with the journal formatting guidelines.

viii. Review and provide comments on drafts of the article.

ix. Address analytic questions and revise analyses, if requested, in response to feedback from reviewers at the CDC, from a journal, or both.

TASK 7. Assess the distribution of age at death and years of potential life lost by categories of causes of alcohol-attributable deaths

a. The contractor is expected to develop an analytic plan and submit it to CDC for review for assessing the number of average annual alcohol-attributable deaths during 2016 – 2020 by the distribution of age at death by categories of causes of death. The categories of causes of death include 100% alcohol-attributable chronic conditions; cancer; heart disease and stroke; conditions of the liver, gallbladder and pancreas; other chronic causes; alcohol-related poisonings; motor vehicle traffic crashes; suicide; and other acute causes. Analyses should also include estimates of years of potential life lost by age group and category of cause of death.

b. The contractor will deliver results to the CDC from analyses on the distribution of age at death and years of potential life lost by categories of causes of alcohol-attributable deaths.

c. The contractor is expected to address questions and suggestions from the CDC Alcohol Program, as needed on the analytic plan and results of analyses.

d. Prepare a manuscript for publication in a peer-reviewed journal, including the following:

v. Lead the development of a manuscript, in collaboration with the CDC Alcohol Program.

vi. The contractor and the CDC Alcohol Program will choose a target journal, and the contractor will format the manuscript according to the journal standards and guidelines for submission. The contractor will then submit a draft of the manuscript to the CDC Alcohol Program scientific lead for review, and the contractor will respond to comments provided by CDC, and submit revised drafts of the manuscript to the CDC Alcohol Program.

vii. After the contractor has addressed all feedback from the CDC Alcohol Program, the manuscript will be submitted to the CDC clearance process with the CDC Alcohol Program scientific lead as a co-author. The contractor then will be expected to work with the CDC Alcohol Program to respond to comments received through the clearance process. After the manuscript has been cleared, the contractor will submit the cleared version of the manuscript to the target journal.

viii. In collaboration with all co-authors and the CDC Alcohol Program, the contractor will respond to comments from journal peer-reviewers and journal editors. If the article is not accepted by the target journal, the contractor will be expected to work with the CDC Alcohol Program to select another journal(s) to submit it to, and then work with the CDC Alcohol Program to help assure a successful outcome for the manuscript.

SECTION 5 – GOVERNMENT FURNISHED MATERIALS

N/A

SECTION 6 – PERIOD OF PERFORMANCE

The period of performance is:

Base Year - 09/30/2020 – 09/29/2021

Option Year One - 09/30/2021 – 09/29/2022

Option Year Two - 09/30/2022 – 09/29/2023

SECTION 7 – DELIVERABLES/REPORTING SCHEDULE

All materials, described below, will be submitted electronically in format that meets CDC standards and is readily available at CDC (e.g. MS Office (Word, Excel, PowerPoint) or Adobe Acrobat. All reporting requirements and written deliverables as part of this contract will be supplied to the project COR and the CDC Alcohol Program scientific lead. Acceptance of any written deliverables is pending COR and CDC Alcohol Program scientific lead’s review and correction to any resulting comments to be confirmed in writing and documented in the closest following monthly report. Any schedule of interim deliverables may be revised according to CDC acceptance of an updated written work plan by the COR during the project with the restriction that these changes must not impact the overall period of performance, scope, or specifications of the award, or otherwise impinge on the authority of the contracting officer. It is the responsibility of the contractor to fully understand what changes require the COR’s approval.

Held no later than (NLT) 10/27/2020

COR and Scientific Lead

20 working days after kickoff call

COR and Scientific Lead

1/25/2021

COR and Scientific Lead

COR and Scientific Lead

4/15/2021

COR and Scientific Lead

COR and Scientific Lead

Option Year 1

10/26/2021

COR and Scientific Lead

COR and Scientific Lead

Option Year 2

10/15/2022

COR and Scientific Lead

1/30/2023

COR and Scientific Lead

COR and Scientific Lead

4/1/2023

COR and Scientific Lead

COR and Scientific Lead

SECTION 8 – REFERENCE MATERIALS

Nelson DE, Naimi TS, Brewer RD, Roeber J. US state alcohol sales compared to survey data, 1993-2006. Addiction. 2010;105(9):1589-96. doi:ADD300710.1111/j.1360-0443.2010.03007.x.

Rey G, Boniol M, Jougla E. Estimating the number of alcohol-attributable deaths: methodological issues and illustration with French data for 2006. Addiction. 2010;105(6):1018-29. doi:10.1111/j.1360-0443.2010.02910.x.

Roerecke M, Vafaei A, Hasan OSM, et al. Alcohol consumption and risk of liver cirrhosis: a systematic review and meta-analysis. Am J Gastroenterol. 2019;114(10):1574-1586. doi:10.14309/ajg.0000000000000340.

Sherk A, Stockwell T, Rehm J, Dorocicz J, Shield KD. The International Model of Alcohol Harms and Policies (InterMAHP): A comprehensive guide to the estimation of alcohol-attributable morbidity and mortality. 2017. www.intermahp.cisur.ca. Accessed March 20, 2020.

Shield KD, Rylett M, Rehm J. Public health successes and missed opportunities: Trends in alcohol consumption and attributable mortality in the WHO European Region, 1990–2014. 2016. http://www.euro.who.int/__data/assets/pdf_file/0018/319122/Public-health-successes-and-missed-opportunities-alcohol-mortality-19902014.pdf. Accessed March 20, 2020.

Stahre M, Naimi T, Brewer R, Holt J. Measuring average alcohol consumption: the impact of including binge drinks in quantity-frequency calculations. Addiction. 2006;101(12):1711-8. doi:10.1111/j.1360-0443.2006.01615.x.

Stahre M, Roeber J, Kanny D, Brewer RD, Zhang X. Contribution of excessive alcohol consumption to deaths and years of potential life lost in the United States. Prev Chronic Dis. 2014;11:E109. doi:10.5888/pcd11.130293.

For more information on CDC’s methods for estimating alcohol-attributable deaths and years of potential life lost, please visit https://nccd.cdc.gov/DPH_ARDI/Info/Methods.aspx.

SECTION 9 – SPECIAL CONSIDERATIONS

HHSAR Provision, 352.239-73: Electronic and Information Technology Accessibility Notice

(a) Section 508 of the Rehabilitation Act of 1973 (29 U.S.C. 794d), as amended by the Workforce Investment Act of 1998 and the Architectural and Transportation Barriers Compliance Board Electronic and Information (EIT) Accessibility Standards (36 CFR part 1194), require that when Federal agencies develop, procure, maintain, or use electronic and information technology, Federal employees with disabilities have access to and use of information and data that is comparable to the access and use by Federal employees who are not individuals with disabilities, unless an undue burden would be imposed on the agency. Section 508 also requires that individuals with disabilities, who are members of the public seeking information or services from a Federal agency, have access to and use of information and data that is comparable to that provided to the public who are not individuals with disabilities, unless an undue burden would be imposed on the agency.

(b) Accordingly, any offeror responding to this solicitation must comply with established HHS EIT accessibility standards. Information about Section 508 is available at http://www.hhs.gov/web/508. The complete text of the Section 508 Final Provisions can be accessed at http://www.access-board.gov/sec508/standards.htm.

(c) The Section 508 accessibility standards applicable to this contract are: 1194.

205 WCAG 2.0 Level A & AA Success Criteria

302 Functional Performance Criteria

502 Inoperability with Assistive Technology

504 Authoring Tools

602 Support Documentation

603 Support Services

In order to facilitate the Government's determination whether proposed EIT supplies meet applicable Section 508 accessibility standards, offerors must submit an HHS Section 508 Product Assessment Template, in accordance with its completion instructions. The purpose of the template is to assist HHS acquisition and program officials in determining whether proposed EIT supplies conform to applicable Section 508 accessibility standards. The template allows offerors or developers to self-evaluate their supplies and documentation detail - whether they conform to a specific Section 508 accessibility standard, and any underway remediation efforts addressing conformance issues. Instructions for preparing the HHS Section 508 Evaluation Template are available under Section 508 policy on the HHS Web site http://hhs.gov/web/508.

In order to facilitate the Government's determination whether proposed EIT services meet applicable Section 508 accessibility standards, offerors must provide enough information to assist the Government in determining that the EIT services conform to Section 508 accessibility standards, including any underway remediation efforts addressing conformance issues.

(d) Respondents to this solicitation must identify any exception to Section 508 requirements. If a offeror claims its supplies or services meet applicable Section 508 accessibility standards, and it is later determined by the Government, i.e., after award of a contract or order, that supplies or services delivered do not conform to the accessibility standards, remediation of the supplies or services to the level of conformance specified in the contract will be the responsibility of the Contractor at its expense.

(e) Electronic content must be accessible to HHS acceptance criteria. Checklist for various formats are available at http://508.hhs.gov/, or from the Section 508 Coordinator listed at https://www.hhs.gov/web/section-508/additional-resources/section-508-contacts/index.html. Materials that are final items for delivery should be accompanied by the appropriate checklist, except upon approval of the Contracting Officer or Representative.

(End of provision)

Requirements for Information Security and/or Physical Access Security Information Security Requirements

A. Baseline Security Requirements

1) Applicability. The requirements herein apply whether the entire contract or order (hereafter “contract”), or portion thereof, includes either or both of the following:

a. Access (Physical or Logical) to Government Information: A Contractor (and/or any subcontractor) employee will have or will be given the ability to have, routine physical (entry) or logical (electronic) access to government information.

b. Operate a Federal System Containing Information: A Contractor (and/or any subcontractor) will operate a federal system and information technology containing data that supports the HHS mission. In addition to the Federal Acquisition Regulation (FAR) Subpart 2.1 definition of “information technology” (IT), the term as used in this section includes computers, ancillary equipment (including imaging peripherals, input, output, and storage devices necessary for security and surveillance), peripheral equipment designed to be controlled by the central processing unit of a computer, software, firmware and similar procedures, services (including support services), and related resources.

2) Safeguarding Information and Information Systems. In accordance with the Federal Information Processing Standards Publication (FIPS)199, Standards for Security Categorization of Federal Information and Information Systems, the Contractor (and/or any subcontractor) shall:

a. Protect government information and information systems in order to ensure:

· Confidentiality, which means preserving authorized restrictions on access and disclosure, based on the security terms found in this contract, including means for protecting personal privacy and proprietary information;

· Integrity, which means guarding against improper information modification or destruction, and ensuring information non-repudiation and authenticity; and

· Availability, which means ensuring timely and reliable access to and use of information.

b. Provide security for any Contractor systems, and information contained therein, connected to an HHS network or operated by the Contractor on behalf of HHS regardless of location. In addition, if new or unanticipated threats or hazards are discovered by either the agency or contractor, or if existing safeguards have ceased to function, the discoverer shall immediately, within one (1) hour or less, bring the situation to the attention of the other party.

c. Adopt and implement the policies, procedures, controls, and standards required by the HHS Information Security Program to ensure the confidentiality, integrity, and availability of government information and government information systems for which the Contractor is responsible under this contract or to which the Contractor may otherwise have access under this contract. Obtain the HHS Information Security Program security requirements, outlined in the HHS Information Security and Privacy Policy (IS2P), by contacting the CO/COR or emailing fisma@hhs.gov.

d. Comply with the Privacy Act requirements and tailor FAR clauses as needed..

3) Information Security Categorization. In accordance with FIPS 199 and National Institute of Standards and Technology (NIST) Special Publication (SP) 800-60, Volume II: Appendices to Guide for Mapping Types of Information and Information Systems to Security Categories, Appendix C, and based on information provided by the ISSO, CISO, or other security representative, the risk level for each Security Objective and the Overall Risk Level, which is the highest watermark of the three factors (Confidentiality, Integrity, and Availability) of the information or information system are the following:

Confidentiality:

[X] Low [ ] Moderate [ ] High

Integrity:

Availability:

Overall Risk Level:

[X] Low [ ] Moderate [ ] High

Based on information provided by the ISSO, Privacy Office, system/data owner, or other security or privacy representative, it has been determined that this solicitation/contract involves:

[X] No PII [ ] Yes PII

Personally Identifiable Information (PII). Per the Office of Management and Budget (OMB) Circular A-130, “PII is information that can be used to distinguish or trace an individual's identity, either alone or when combined with other information that is linked or linkable to a specific individual.” Examples of PII include, but are not limited to the following: social security number, date and place of birth, mother‘s maiden name, biometric records, etc.

PII Confidentiality Impact Level has been determined to be: [X] Low [ ] Moderate [ ] High

4) Controlled Unclassified Information (CUI). CUI is defined as “information that laws, regulations, or Government-wide policies require to have safeguarding or dissemination controls, excluding classified information.” The Contractor (and/or any subcontractor) must comply with Executive Order 13556, Controlled Unclassified Information, (implemented at 3 CFR, part 2002) when handling CUI. 32 C.F.R. 2002.4(aa) As implemented the term “handling” refers to “…any use of CUI, including but not limited to marking, safeguarding, transporting, disseminating, re-using, and disposing of the information.” 81 Fed. Reg. 63323. All sensitive information that has been identified as CUI by a regulation or statute, handled by this solicitation/contract, shall be:

a. marked appropriately;

b. disclosed to authorized personnel on a Need-To-Know basis;

c. protected in accordance with NIST SP 800-53, Security and Privacy Controls for Federal Information Systems and Organizations applicable baseline if handled by a Contractor system operated on behalf of the agency, or NIST SP 800-171, Protecting Controlled Unclassified Information in Nonfederal Information Systems and Organizations if handled by internal Contractor system; and

d. returned to HHS control, destroyed when no longer needed, or held until otherwise directed. Destruction of information and/or data shall be accomplished in accordance with NIST SP 800-88, Guidelines for Media Sanitization.

5) Protection of Sensitive Information. For security purposes, information is or may be sensitive because it requires security to protect its confidentiality, integrity, and/or availability. The Contractor (and/or any subcontractor) shall protect all government information that is or may be sensitive in accordance with OMB Memorandum M-06-16, Protection of Sensitive Agency Information by securing it with a FIPS 140-2 validated solution.

6) Confidentiality and Nondisclosure of Information. Any information provided to the contractor (and/or any subcontractor) by HHS or collected by the contractor on behalf of HHS shall be used only for the purpose of carrying out the provisions of this contract and shall not be disclosed or made known in any manner to any persons except as may be necessary in the performance of the contract. The Contractor assumes responsibility for protection of the confidentiality of Government records and shall ensure that all work performed by its employees and subcontractors shall be under the supervision of the Contractor. Each Contractor employee or any of its subcontractors to whom any HHS records may be made available or disclosed shall be notified in writing by the Contractor that information disclosed to such employee or subcontractor can be used only for that purpose and to the extent authorized herein.

The confidentiality, integrity, and availability of such information shall be protected in accordance with HHS and CDC policies. Unauthorized disclosure of information will be subject to the HHS/CDC sanction policies and/or governed by the following laws and regulations:

a. 18 U.S.C. 641 (Criminal Code: Public Money, Property or Records);

b. 18 U.S.C. 1905 (Criminal Code: Disclosure of Confidential Information); and

c. 44 U.S.C. Chapter 35, Subchapter I (Paperwork Reduction Act).

7) Internet Protocol Version 6 (IPv6).