Small Business Sources Sought_Attached PD.pdf

75N95020Q00210

Purchase Description

The contractor shall provide the following brand-name or equal items. Item descriptions and salient characteristics (where applicable) begin on page 2.

Line Item No.

Item Part No. Qty

Equipment and Accessories 1 ACQUITY H-Class PLUS Bio System (CM-A) 176015106 1 2 ACQUITY UPLC TUV Detector 176015028 1 3 Xevo G2-XS QTOF 4k UNIFI 176003484 1 4 Oil-Less Vacuum Pump 176002847 1 5 UNIFI P-Series 176004034 1 6 Biopharmaceutical Platform Solution Application Kit 176001194 1 7 Progenesis Sm Molecule Processing Workstation 176004027 1 8 Monitor, 27" 668000419 2 9 Power Supply, Uninterruptable 5.2KV 725000473 1

10 Fluidics tubing and fittings 700004189 1 Software

11 The UNIFI Workstation Software 176002738 1 12 UNIFI Workstation Large Molecule Option 667003916 1 13 UNIFI Workstation Small Molecule Option 667004656 1 14 Maint 1Yr: UNIFI Workstation Software - 1 15 Biopharmaceutical Install Certificate 741000463 1 16 Progenesis QI - Single user 176003431 1 17 EZ Info 176003497 1

Installation 18 MS Ref Stds: Xevo TOF Biopharma Install 176002519 1 19 Biopharmaceutical Platform Solution Installation Kit 176001195 1 20 Analytical LC-MS Solvent Install Kit 176003950 1 21 Metabolomic Solution Installation Kit 176002938 1 22 WORPS Metabolomics Doc Set (Xevo G2-S) 715004096 1

Training 23 Fundamentals of UNIFI Core Topics eLearning Track 750002011 1

24 Introductory Familiarization for LCMS TOF-based Systems eLearning track

750002034 1

25 5-day On-Site MS App Training w/eLearn 750000840 1 Optional Support and Service Agreements

26 Option: Maint 1Yr: UNIFI Workstation Software (2021-2022) - 1 27 Option: Maint 1Yr: UNIFI Workstation Software (2022-2023) - 1 28 Option: Total Assurance Plan (TAP) (2021 – 2022) - 1 29 Option: Total Assurance Plan (TAP) (2022 – 2023) - 1 30 Option: Total Assurance Plan (TAP) (2023 – 2024) - 1 31 Option: Total Assurance Plan (TAP) (2024 – 2025) - 1

Item Descriptions and Salient Characteristics

Line Item 1: ACQUITY H-Class PLUS Bio System (CM-A) DESCRIPTION: A Column Manager System with integrated solvent, sample and multi-column heating and cooling capabilities with two, independent temperature-controlled zones. The system may be configured for a broad range of applications supported by UPLC optical detectors and mass detectors, with a choice of instrument control and data management software.

SALIENT CHARACTERISTICS:

a. Configured for quaternary solvent delivery (bioQSM)

b. Configured for sample introduction via a direct inject sample manager (bioSM-FTN-H)

c. Includes column manager with active pre-heating (CM-A)

d. Includes BEH C18 Column, 2.1 x 50 mm, 1.7 ¼m

e. Includes a solvent tray module, Start Up Kit, Leak Sensors, Start-up Solution, Information Set, and Systems Driver Pack 4 DP2018R1.

Line Item 2: ACQUITY UPLC TUV Detector DESCRIPTION: The Waters ACQUITY UPLC Tunable UV (TUV) detector is a dual-wavelength Ultraviolet/Visible (UV/Vis) detector for use in the ACQUITY UPLC H-Class system. Optimized for Ultra Performance Liquid Chromatography, the TUV detector's innovative light-guided flow cell and low-noise electronics result in a detector that delivers the utmost in UPLC sensitivity.

SALIENT CHARACTERISTICS:

a. Detector wavelength range of at least 200-600nm.

b. Supports single or dual wavelength operating modes

c. Detector response is linear up to 2.5 AU; dynamic range extends to 4.0 AU.

d. Wavelength spectral scanning, including automatic blank subtraction, can be stored in memory.

Line Item 3: Xevo G2-XS QTOF 4k UNIFI DESCRIPTION: High-performance benchtop QTOF mass spectrometer incorporating the XS Collision Cell for enhanced sensitivity and selectivity, resulting in the highest quality, most comprehensive qualitative information together with the ultimate in quantitative performance.

SALIENT CHARACTERISTICS:

a. On-board infusion system capable of delivering reference solutions from 3 built-in vial locations. The fluidics system is controlled by software to provide automated instrument setup and mass calibration.

b. Includes a high-performance quadrupole mass analyzer and a high performance TOF mass analyzer

c. Collision energy is under programmable software control. The collision energy and collision gas pressure used during data acquisition are automatically recorded and appended to the relevant data file.

d. Includes a differentially pumped, automated vacuum system

Line Item 4: Oil-Less Vacuum Pump DESCRIPTION: A direct drive rough pump or equivalent for obtaining vacuum on MS system.

Line Item 5: UNIFI P-Series DESCRIPTION: UNIFI P-Series is the computer used to operate the instrument and run UNIFI software.

This computer is suitable for a UNIFI Workstation installation for TOF applications.

SALIENT CHARACTERISTICS:

a. Includes Processor

b. Includes at least 4x16 GB Memory

c. Includes graphic card

d. Includes at least 512GB Storage for OS

e. Includes storage for Database and for Backup

Line Item 6: Biopharmaceutical Platform Solution Application Kit DESCRIPTION: Biopharmaceutical Platform Solution Application Kit contains a series of analytical columns geared towards the biopharmaceutical applications.

Line Item 7: Progenesis Sm Molecule Processing Wrkstn DESCRIPTION: A workstation for running the Progenesis QI software

Line Item 8: Monitor, 27"

Line Item 9: Power Supply, Uninterruptable 5.2KV

Line Item 10: Fluidics tubing and fittings

Line Item 11: UNIFI Workstation Software DESCRIPTION: Personal Workstation Base Software kit

SALIENT CHARACTERISTICS:

a. Includes user licenses

b. Includes installation DVD

c. Includes on-line assistance

d. Includes configuration guide(s) for at least installation and/or upgrade

Line Item 12: UNIFI Workstation Large Molecule Option DESCRIPTION: UNIFI Large Molecule Option adds software workflows and tools that are geared towards applications like Peptide Mapping, Intact Protein analysis and Antibody Drug Conjugate work. It has specific processing functions for large molecule work such as work with proteins and peptides.

Line Item 13: UNIFI Workstation Small Molecule Option DESCRIPTION: UNIFI Small Molecule Option adds software workflows and tools geared towards small molecule applications such as Metabolomics and Lipidomics. This includes the following tools: Dealkylation Tool, MassFragment Tool, and the IsoScore™ Tool.

Line Item 14: Maint 1Yr: UNIFI Workstation Software DESCRIPTION: One year of software maintenance (upgrades, patches, etc.).

Line Item 15: Biopharmaceutical Install Certificate DESCRIPTION: Software certificate enabling the biopharmaceutical platform on the instrument.

Line Item 16: Progenesis QI - Single user DESCRIPTION: License for Progenesis QI small molecule discovery software.

Line Item 17: EZ Info DESCRIPTION: EZInfo is a supported option for UNIFI and Progenesis software. EZinfo helps you make sense of the information in your LC-MS data in an easy way, allowing you to view and investigate the results in a simple and user-friendly report. It analyzes data and provides useful statistical information.

Line Item 18: MS Ref Stds: Xevo TOF Biopharma Install DESCRIPTION: Installation of MS reference standards onto system by service engineer.

Line Item 19: Biopharmaceutical Platform Solution Installation Kit DESCRIPTION: The Biopharmaceutical Platform Solution Installation Kit contains items used during installation of the instrument. They are used to spec certain workflows on the instrument.

Line Item 20: Analytical LC-MS Solvent Install Kit DESCRIPTION: Minimizes sources of possible contamination during the installation process of new LC-MS systems. This kit includes the LC-MS Grade Solvent Kit (186008715), as well as the Waters Certified Container Kit (186007088).

Line Item 21: Metabolomic Solution Installation Kit DESCRIPTION: The metabolomic solution installation kit consists of standards used during installation to make sure the instrument is meeting specification.

Line Item 22: WORPS Metabolomics Doc Set (Xevo G2-S) DESCRIPTION: A set of supporting documents for the instrument and installation documents.

Line Item 23: Fundamentals of UNIFI Core Topics eLearning Track DESCRIPTION: Learn at your own pace training. On demand professional analytical training geared towards UNIFI software. The Fundamentals of UNIFI track is the foundation for learning UNIFI and covers core UNIFI features and navigation of key UNIFI workflows. The track will cover the following topics:

Introduction to UNIFI, Generating Results, Building Methods and Managing UNIFI.

Line Item 24: Introductory Familiarization for LCMS TOF-based Systems eLearning track DESCRIPTION: Learn at your own pace training. On demand professional analytical training geared towards basic familiarization for new users of Waters LCMS TOF based systems. This track covers simple tasks, tuning and calibration, LC and MS methods on a Waters instrument.

Line Item 25: 5-day On-Site MS App Training w/eLearn DESCRIPTION: Training on the Waters Xevo G2-XS QTOF with ACQUITY H-Class Plus Bio System.

SALIENT CHARACTERISTICS:

a. On-site, in-person training for NCATS staff in Rockville, MD

Line Items 26-27: Options: Maint 1Yr: UNIFI Workstation Software DESCRIPTION: One year of software maintenance (upgrades, patches, etc.).

Line Items 28-31: Options: Total Assurance Plan (TAP) DESCRIPTION: One year of service coverage after the manufacturer’s initial warranty.

SALIENT CHARACTERISTICS: Provides coverage and at least one preventative maintenance visit for each of the following items:

a. ACQUITY H-Class PLUS Bio System (CM-A)

b. ACQUITY TUV Detector

c. Xevo G2-XS QTOF 4k UNIFI

d. ACQUITY H-Class bioQuaternary Solvent Manager (bioQSM) PLUS (included in H-Class PLUS Bio System)

e. ACQUITY UPLC H-Class bioSample Manager # FTN (bioSM-FTN-H) PLUS (included in H-Class PLUS Bio System)