Amendment 001 SB1341-12-RQ-0319.pdf

NSN 7540-01-152-8070 STANDARD FORM 30. (Rev. 10-83) Previous Edition unusable Prescribed by GSA FAR (48 CFR) 53.243

Page of Pages AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. Contract ID Code

2. AMENDMENT MODIFICATION NO. 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ. NO. 5. PROJECT NO. (if applicable)

6. ISSUED BY CODE 7. ADMINISTERED BY (If other than item 6) CODE

(x) 9A. AMENDMENT OF SOLICITATION NO.

9B. DATED (SEE ITEM 11)

10A. MODIFICATION OF CONTRACT/ORDER NO.

8. NAME AND ADDRESS OF CONTRACTOR (NO., Street, Country, State and ZIP Code)

CODE FACILITY CODE

10B. DATED (SEE ITEM 13)

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

The above numbered solicitation is amended as set forth in item 14. The hour and date specified for receipt of offers is extended, is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:

(a) By completing items 8 and 15, and returning ______ copies of amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted;

or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OR OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment your desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

12. ACCOUNTING AND APPROPRIATION DATA (If required)

13. THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

Check One

A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE

CONTRACT ORDER NO. IN ITEM 10A.

B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

D. OTHER (Specify type of modification and authority)

E. IMPORTANT: Contractor is not, is required to sign this document and return _______ copies to the issuing office.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)

Except as provided herein, all terms and conditions of the document referenced in item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print)

16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

15B. CONTRACTOR/OFFEROR 16B. UNITED STATES OF AMERICA

(Signature of person authorized to sign)

15C. DATE SIGNED

(Signature of Contracting Officer)

16C. DATE SIGNED

Attachment Page

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3. STATEMENT OF WORK

TITLE: Mass Spectrometry of Natural Products

I. BACKGROUND INFORMATION

This procurement is being conducted for the U. S. Department of Commerce (DOC), National Institute of Standards and Technology (NIST), Material Measurement Laboratory (MML), Chemical and Biochemical Reference Data Division (CBRDD) in Gaithersburg, Maryland. The Mass Spectrometry Data Center (MSDC), a component of the CBRDD, is responsible for the development of NIST/NIH/EPA Mass Spectral Library (the Library, http://nist.gov/srd/nist1.htm ) including software and NIST Chemistry web-book (http://webbook.nist.gov/chemistry/).

II. SCOPE OF WORK

The Contractor shall furnish the necessary personnel, material, equipment, services and facilities (except as otherwise specified) to perform the following Statement of Work/Specifications.

a. GENERAL:

The purpose of this contract is to conduct Gas Chromatography – Mass Spectrometry (GC-MS, http://en.wikipedia.org/wiki/Gas_chromatography-mass_spectrometry) data examination for natural products with the use of Automated Mass Spectral Deconvolution and Identification System located at the following web site for (AMDIS), http://chemdata.nist.gov/mass-spc/amdis/changes.html , http://chemdata.nist.gov/mass-spc/amdis/docs/amdis.pdf, http://www.sisweb.com/software/ms/nist.htm#amdis).

b. SPECIFIC REQUIREMENTS:

To acquire contractor support to develop mass spectral libraries of chemicals found in natural products.

Task one: The contractor shall conduct an evaluation of GC-MS files of plant and soil extracts, essential oils, food products including beverages, tissue, plasma and urine samples and submit written technical report to COR as detail below in Section VI-Deliverables.

Task two: The contractor shall provide recommendations to the NIST/COR for new measurements with the use of chemical derivatization of samples prior to the GC-MS analysis and/or with the use additional mass spectrometry methods: Liquid Chromatography – Mass Spectrometry (LC-MS, located at the following website:

http://en.wikipedia.org/wiki/Liquid_chromatography%E2%80%93mass_spectrometry ) and Tandem Mass Spectrometry located at the following website for (TMS),http://en.wikipedia.org/wiki/Tandem_mass_spectrometry).

Task three: The contractor shall evaluate GC-MS, LC-MS and TMS data files upon completion of recommendations of new measurements under Task 2 by the COR.

PAGE 3 OF 9 SB1341-12-RQ-0319/001

Task four: The contractor shall develop the AMDIS software by improving its ability (a) to process large data sets of data, (b) to add filtering mechanisms for rejection of spurious peaks, and (c) to allow for positive as well as negative contributions from extremely low variations between library and experimental retention indices for handling complex data files of natural products.

The contractor shall develop post processing algorithms to allow AMDIS results to be used in automatic library formation; the code (http://en.wikipedia.org/wiki/Code ) shall be well structured, adequately commented and tested under Windows NT, 2000, XP, Vista and Windows 7 operational system, or the current environment at the time of testing.

Task five: The contractor shall develop special mass spectral libraries of known and unknowns in the samples of natural products.

Task six: The contractor shall submit monthly status reports to the Contracting Officer Representative (COR) by the 15th day of the following month. The status reports, at a minimum, must address which deliverables have been completed, any outstanding deliverables, any delays, and reason for delays.

III. PERIOD OF PERFORMANCE

The anticipated base Period of Performance will be a base period of twelve (12) months, from the effective date of contract award, and three (3) one year option periods.

IV. PLACE OF PERFORMANCE

Services shall be performed at NIST, Gaithersburg, Maryland campus and/or contractors’ site.

Normal duty hours at NIST are 8:30am to 5:00pm, Monday through Friday, with the exception of Federal holidays or other official closures (http://www.opm.gov/operating_status_schedules/fedhol/2012.asp ).

V. GOVERNMENT FURNISHED PROPERTY

Upon award of contract, NIST will provide to the contractor, office, equipment, email and internet access, and NIST library access. The contractor will be given an access to all scientific data of the Chemical Reference Data Group.

VI. DELIVERABLES

MONTHLY PROGRESS REPORT

The contractor shall provide monthly progress report to the COR via electronic mail every second Tuesday of the month. The report shall include details of the prior period’s activities, status of development and scheduled performance, and/or any problems, issues or risks identified

PAGE 4 OF 9 SB1341-12-RQ-0319/001

during this period. It should also detail any resolution on previously identified problems, issues and/or risks.

(1) The content of the monthly progress reports shall contain the following: Contractor’s name, Contract #, date of report, the period covered by the report, title of report;

(2) Description of the progress made against milestones during the reporting period;

(3) Results, positive and negative, obtained related to previously identified problem areas, with conclusions and recommendations;

(4) Any significant changes to the contractor’s organization or method of operation, to the project management network, or to the milestone chart;

(5) Problem areas affecting technical or scheduling elements, with background and any recommendations for solutions beyond the scope of contract;

(6) Problem areas possibly affecting various aspects of the debt collection program, with background and any recommendations for solutions beyond the scope of contract;

(7) Any cost incurred and person-expended for the reporting period and total contractual expenditures for each as reporting dates;

(8) Any significant trips and results;

(9) Record of all significant telephone calls and any commitments made by telephone;

Problem areas possibly affecting various aspects of the debt collection program, with background and any recommendations for solutions beyond the scope of contract;

(10) Summary of important meetings, briefings, trips, and conferences during the reported period;

(11) Action items requiring the Federal government’s resolution;

(12) Plans and activities during the following reporting period;

(13) Name and telephone numbers of the prepare of the report, and

(14) Appendices for any unnecessary tables, references, illustrations and charts.

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Number Referen ce

Description Format Quantity Due Date

Task 1. The contractor shall conduct evaluation of GC-MS files of plant and soil extracts, essential oils, food products including beverages, tissue, and plasma and urine samples.

A technical report in a text format.

1 report per month

Due every second Tuesday of the month

Task 2 The contractor shall provide recommendations for new measurements with the use of chemical derivatization of samples prior to the GC-MS analysis and/or with the use additional mass spectrometry methods: Liquid Chromatography – Mass Spectrometry (LC-MS) and Tandem Mass Spectrometry (TMS).

A technical report in a text format.

1 report per month

Due second Tuesday of the month

Task 3 The contractor shall evaluate GC-MS, LC-MS and TMS data files when available (see Task Two).

A technical report in a text format.

1 report per month

Due second Tuesday of the month

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Number Referen ce

Description Format Quantity Due Date

Task 4 The contractor shall develop AMDIS software by improving its ability (a) to process large data sets of data, (b) to add filtering mechanisms for rejection of spurious peaks, and (c) to allow for positive as well as negative contributions from extremely low variations between library and experimental retention indices for handling complex data files of natural products.

Contractor shall develop post processing algorithms to allow AMDIS results to be used in automatic library formation; the code shall be well structured, adequately commented and tested under Windows NT, 2000, XP, Vista and Windows 7 operational system environment.

A technical report in a text format.

1 report per month

Due second Tuesday of the month

Task 5 Task five: The contractor shall develop special mass spectral libraries of known and unknowns in the samples of natural products.

Submit special library in

NIST

library format.

1 library per month

Due second Tuesday of the month

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Number Referen ce

Description Format Quantity Due Date

Task 6 Task six: Monthly status reports must be provided monthly to the Contracting Officer Representative (COR) electronically via email. The status reports, at a minimum, must address which deliverables have been completed under the contract, outstanding deliverables, any delays, and reason for delays.

A technical report in a text format.

1 report per month

Due second Tuesday of the month

VII. INSPECTION/ACCEPTANCE

The data shall undergo the procedure of acceptance testing. The guidelines for data examination are defined by NIST in the document “The critical evaluation of a comprehensive mass spectral library”, published in the Journal American Society for Mass Spectrometry, 1999, vol. 10, p, 287-299. Below are the URLs for information purposes:

http://chemdata.nist.gov/mass-spc/pubs/ http://www.springerlink.com/content/u5g6713x45115876/fulltext.pdf http://www.springerlink.com/content/u5g6713x45115876/?MUD=MP

The COR will provide comments on each deliverable within 3 calendar days from receipt of a given deliverable. The contractor shall make any needed changes to the deliverables within 5 calendar days from receipt of electronic or written comments from the COR. The criteria for acceptance shall be that over 97% of the data submitted to NIST are found acceptable.

VIII. TRAVEL

Travel to the American Society for Mass Spectrometry (ASMS), PITTCON and International Mass Spectrometry (IMS) Conferences is required:ऀ

- 19th IMS Conference (September 15-21, 2012, Kyoto, Japan),

- PITTCON 2013 (March 17-22, 2013, Philadelphia, PA),

- 61st ASMS Conference (June 9-13, 2013, Minneapolis, MN),

- PITCCON 2014 (March 2-7, 2014, Chicago, IL),

- 62nd ASMS Conference (June 15-19, 2014, Baltimore, MD), PAGE 8 OF 9 SB1341-12-RQ-0319/001

- 20th IMS Conference (2014)

- PITTCON 2015 (March 8-14, 2015, New Orleans, LA)

- 63rd ASMS Conference (May 31- June 4, 2015, St. Louis, MO).

Travel will be reimbursed in accordance with the Federal Travel Regulation (FTR) and FAR 31.205-46 -- Travel Costs. Travel will not exceed the maximum per diem rate (meals and lodging), and transportation costs, in effect at the time of travel.

( http://www.gsa.gov/portal/category/21287 ).

IX. Contractor Qualifications:

At a minimum, proposed personnel shall have a degree in chemistry or physics, at least 3 years’ experience on mass spectrometry and analyzing GC-MS, LC-MS and TMS data files, at least 3 years experience on developing chemical databases, and at least 1 year experience in programming in C++.

(X) GENERAL INFORMATION

The services do not involve confidential or proprietary data. The Certification and Accreditation (C&A) or Assessment and Authentication (A&A) requirements of Clause 1352.239-72 do not apply and a Security Accreditation Package is not required.

Safety: The Contractor employee shall be responsible for knowing and complying with NIST installation safety prevention regulations (http://www-i.nist.gov/mml/safety/policies/index.htm. ). Such regulations include, but are not limited to, general safety, fire prevention, and waste disposal.

Patent Rights: The Government retains a Government use license to all inventions arising from this work.

Security: NIST is a restricted campus. An identification badge is required for access for entry into buildings and must be presented to the Security Police when entering the campus.

Identification Badges: Contractor employees shall comply with NIST identification and access requirements. The Contractor employee is responsible for absences due to expired identification and access documents. Each Contractor employee shall wear a visible identification badge provided by the NIST Security Office. The badge must show the full name, title, and if required by NIST, the words “Contractor” in front. The Contractor employee shall turn in the NIST identification badge and vehicle pass to the COR or Contracting Officer (CO) upon termination of their services under this contract.

Vehicle Registration: All Contractor employees must register their vehicles with the NIST Security Office to gain access to the campus. A valid driver’s license, Government-furnished civilian ID, proof of insurance and current registration must be presented to the NIST Security Office, at which time a NIST vehicle pass will be issued. The pass shall be displayed on the

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vehicle’s rear view mirror in accordance with instructions. Contractor employees shall follow NIST procedures for removal and turn-in of the vehicle pass upon termination of services under this contract.

Media Inquiries: The Contractor employee shall not respond to any media inquiries.

100 BUREAU DRIVE STOP 1640

BUILDING 301 ROOM B129

GAITHERSBURG MD 20899-1640