SAM_-_Pre-Solicitation__75N94025Q00135_1.pdf

75N94025Q00135

INTRODUCTION

THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT

OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION.

The National Institutes of Health, National Institute of Child Health and Development (NICHD), in support of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) intends to award a purchase order without providing for full and open competition to LIFE TECHNOLOGIES CORPORATION for ProcartaPlex Immuno-panel plates to support NIAAA Translational Research Projects.

BACKGROUND

The goal of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), Section on Neural Circuits is to understand how genetic and environmental insults affect the computation of neural signals within brain networks to cause neurodevelopmental disorders like autism, epilepsy and attention deficit/ hyperactivity disorder.

The Section on Neural Circuits at NIAAA needs immuno-panel plates for human and mouse for use with our Luminex xMAP INTELLIFLEX System (Catalog number APX2020), to significantly enhance our research capabilities in high-throughput multiplex protein expression analysis. This technology is essential for advancing our translational research efforts, particularly in projects that require the efficient and simultaneous quantification of numerous targets from limited biological material. The immune plates using the INTELLIFLEX platform enables the detection of up to 80 different proteins or gene expression markers in a single assay using as little as 25 μL of sample. This is especially critical when working with precious clinical samples or small-volume animal models. Unlike many other systems, it allows the detection of protein in samples without the need for stripping and reprobing, streamlining workflow and reducing potential sample loss or degradation. These plates will directly support current and future projects involving blood, tissue, and cell-based assays and allow for more comprehensive and timely analysis of protein expression in both preclinical and clinical studies.

JUSTIFICATION

The Luminex xMAP INTELLIFLEX System (Catalog number APX2020, enables efficient and simultaneous quantification of up to 80 different proteins or gene expression targets in small sample volumes (as little as 25 μL). This request supplies the immune pannel plates for human and mouse for use with our Luminex xMAP INTELLIFLEX system to significantly enhance our research capabilities in high-throughput multiplex protein expression analysis. Technologies/Thermo Fisher is the only supplier offering these protein multiplexed assays on the Luminex platform. We are not aware of any alternative multiplex kits that are comparable to the Life Technologies/Thermo Fisher kits or that are compatible with the Luminex platform. As far as we know, Life Technologies/Thermo Fisher is the only distributor for the Luminex platform. We have already used these same multiplex kits to identify immune molecules activated by the thermal and immune components of fever, therefore we need the same kits in order to continue this work with additional samples and ensure continuity of our research.

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE

The intended procurement is classified under 334516 - Analytical Laboratory Instrument Manufacturing with a Size standards in number of employees: 1,000

PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS

75N94025Q00135

REGULATORY AUTHORITY

The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Regulation (FAR) Circular (FAC) 2025-04 effective 06/11/2025. This acquisition is conducted under the procedures as prescribed in FAR subpart 13-Simplified Acquisition Procedures at an amount not exceeding the simplified acquisition threshold ($250,000) and FAR Subpart 12- Acquisition of Commercial Items.

STATUTORY AUTHORITY

This acquisition is conducted under the authority of FAR 13.106(b)(1) Soliciting from a single source - For purchases not exceeding the simplified acquisition threshold.

PLACE OF DELIVERY

NIH/NIAAA

5625 FISHERS LANE RM TS-06B

ROCKVILLE MD 20852

DESCRIPTION OF REQUIREMENT

Delivery of the human and mouse immune-panel plates and buffer

EXP-99999-000, Cell Lysis Buffer 20 ML

EXP480-20834-901 MO Immune Monitoring 48 Plex 96 Tests

EXP800-10080-901 HU Imune Response 80 Plex 96 Tests

Shipping/Freight

PERIOD OF PERFORMANCE

Delivery by 60 Days ARO

CLOSING STATEMENT

This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability in response to this notice and may submit a capability statement, which shall be considered by the agency. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

All respondents must have an active registration in the System for Award Management (SAM) www.sam.gov. All responses to this notice shall be submitted electronically by 5:00 PM Eastern Daylight Time, on July, 29th, 2025 to jacob.balenson@nih.gov and shall include pre-solicitation # 75N94025Q00135 in the subject line.